A5003297108- Estrogen and related hormone effects
- Glioma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- Male Breast Health Studies
- Single-cell and spatial transcriptomics
- RNA Research and Splicing
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Cancer and Skin Lesions
- Cancer Cells and Metastasis
- Mental Health and Psychiatry
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Psychosomatic Disorders and Their Treatments
- Prion Diseases and Protein Misfolding
- 3D Printing in Biomedical Research
- Insect symbiosis and bacterial influences
- Insect and Pesticide Research
- Occupational and environmental lung diseases
- Insect and Arachnid Ecology and Behavior
- Genomics and Chromatin Dynamics
- Alcoholism and Thiamine Deficiency
- NF-κB Signaling Pathways
St James's University Hospital
2010-2024
University of Leeds
2009-2024
University of York
2014
Marymount University
2012
Institute of Molecular Medicine
2011
Wellcome Trust
2010
Maudsley Hospital
1994
Manchester Royal Infirmary
1988-1990
A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished studies unselected cases. We determined the prognostic significance tumour–stroma ratio (TSR) oestrogen receptor (ER)-positive male and female carcinomas. TSR was measured haematoxylin eosin-stained tissue sections (118 62 male). Relationship (cutoff 49%) to overall (OS) relapse-free (RFS) analysed. Tumours with ⩾49% were associated better (OS P=0.008, HR=0.2–0.7; RFS P=0.006, HR=0.1–0.6)...
Glioblastoma (GBM) brain tumors lacking IDH1 mutations (IDHwt) have the worst prognosis of all neoplasms. Patients receive surgery and chemoradiotherapy but almost always fatally recur.
Models considering breast cancer complexity cannot be easily or accurately replicated in routine cell line animal models. We aimed to evaluate the practicality of organotypic tissue slice culture cancer. Following ethical approval, 250 µm thick sections from surplus tumours (n=10) were prepared using a vibrating blade microtome. Triplicate slices placed 6-well plates and cultured for up 7 days±tamoxifen (1 nM) doxorubicin µM). Tissue fixed embedded before sectioning morphological evaluation...
Symbionts can substantially affect the evolution and ecology of their hosts. The investigation tissue-specific distribution symbionts (tissue tropism) provide important insight into host-symbiont interactions. Among other things, it help to discern importance specific transmission routes potential phenotypic effects. intracellular bacterial symbiont Wolbachia has been described as greatest ever panzootic, due wide array arthropods that infects. Being primarily vertically transmitted, is...
Glioblastoma (GBM), the most aggressive adult brain cancer, comprises a complex tumour microenvironment (TME) with diverse cellular interactions driving progression and pathobiology. How these spatial patterns evolve treatment remains unclear. Here, we apply imaging mass cytometry to analyse protein-level changes in paired pre- post-treatment GBM samples from five patients. We find significant increase normal cells alongside reduction vascular cells. Moreover, despite minimal overall change...
Characterizing and quantifying cell types within glioblastoma (GBM) tumors at scale will facilitate a better understanding of the association between cellular landscape tumor phenotypes or clinical correlates. We aimed to develop tool that deconvolutes immune neoplastic cells GBM microenvironment from bulk RNA sequencing data.
Abstract Oestrogen receptors (ERs) are critical regulators of the behaviour many cancers. Despite this, roles and regulation one two known ERs – ERβ– poorly understood. This is partly because analyses have been confused by discrepancies between ERβ expression at mRNA proteins levels, expressed as several functionally distinct isoforms. We investigated human 5′ untranslated regions (UTRs) their influences on function. demonstrate that alternative 5′UTRs potent differential acting level...
Ninety three female neurological in-patients were assessed in a collaborative and psychiatric study. An overall prevalence of definite disorder 34% was found, depression being the most common diagnosis. Psychiatric morbidity when neurologist felt that presentation could not be explained by disorder. The majority such patients had symptoms which but substantial number given General Health Questionnaire found to useful screening instrument this setting.
Pathological reporting of breast cancer has evolved alongside scientific advances. Such advances have led to recognition different molecular classes resulting in improved disease management. The aim this study was establish whether these could be applied archival cases dating from the 1940s assess historical trends. Important observations included marked differences pathological reporting, size tumour and ERα expression throughout decades.
Owing to its rarity, large-scale retrospective studies in male breast cancer have suffered from the small numbers of cases available for study any one center. Here we describe our experience establishing a large collection cancers tissue microarray format suitable biomarker analysis by immunohistochemistry.
Synopsis Two male patients who presented with unusual pictures of dementia in the absence other obvious symptoms or signs are reported. Investigations demonstrated changes highly suggestive multiple sclerosis (MS) on magnetic resonance imaging, cerebrospinal fluid analysis and electrophysiological tests. We suggest this represents a rare presentation sclerosis.
Verghese E T, Shenoy H, Cookson V J, Green C A, Howarth Partanen R Pollock S, Waterworth Speirs V, Hughes T A & Hanby M(2011) Histopathology59, 609–618 Epithelial–mesenchymal interactions in breast cancer: evidence for a role of nuclear localized β-catenin carcinoma-associated fibroblasts Aims: Characteristics the stroma around tumours are critical defining behaviour cancers. β-Catenin is well established as regulator carcinogenesis, acting transcriptional co-activator nuclei epithelial...
We present a case of male patient with breast mass, found to be malignant mesothelioma.We discuss the diagnostic challenges, need for heightened awareness in suspected cases, histological classification mesotheliomas and treatments available.We believe this second reported mesothelioma presenting as mass.
We report the case of an alcoholic woman with confusion, catatonia and extrapyramidal signs, who developed features Wernicke-Korsakoff syndrome after treatment intravenous high potency vitamins. emphasise that this should arouse suspicion nicotinic acid deficiency even in absence gastrointestinal symptoms or skin lesions.
Abstract AIMS The rapid recurrence of therapy-resistant glioblastoma leaves patients with a dismal 2-year survival rate just 16%, highlighting the need to develop treatments that combat or prevent recurrence. Recently, have been stratified by their gene expression response therapy. Specifically, genes JARID2 binding sites in promoter (JBS-genes) either become up- down-regulated on progression from primary recurrent tumour. Importantly, these two responses appear employ different mechanisms...
Abstract The biological and clinical impact of neoplastic immune cell type ratios in the glioblastoma (GBM) tumour microenvironment is being realised. Characterising quantifying types within GBMs at scale will facilitate a better understanding association between cellular landscape phenotypes or correlates. This study aimed to develop tool that can deconvolute cells GBM from bulk RNA sequencing data. We developed an IDH wild-type (IDHwt) specific single reference dataset, four independent...
On the Cover: A murine model for subretinal hemorrhage, which recapitulates features of clinical disease, may be useful evaluating potential experimental therapies.Histologic section shows a retina at 2 weeks after blood injection, demonstrating resolution hemorrhage and development outer retinal atrophy (apoptosis, red; nuclei, blue).(See page 1265.