A5031708559- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Protease and Inhibitor Mechanisms
- Wound Healing and Treatments
- TGF-β signaling in diseases
- Cancer Cells and Metastasis
- Dermatologic Treatments and Research
- Cellular Mechanics and Interactions
- Proteoglycans and glycosaminoglycans research
- Phagocytosis and Immune Regulation
- Cancer, Hypoxia, and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Fibroblast Growth Factor Research
- Platelet Disorders and Treatments
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- Hair Growth and Disorders
- Ocular Oncology and Treatments
- Complement system in diseases
- Glycosylation and Glycoproteins Research
- Acute Myeloid Leukemia Research
- Tissue Engineering and Regenerative Medicine
- Nonmelanoma Skin Cancer Studies
- Renal and related cancers
- Vascular Tumors and Angiosarcomas
University of Oulu
2015-2024
University of Bergen
2016-2022
Matrix Research (United States)
2010-2022
Biocenter Finland
2006-2014
Oulu University Hospital
2013
Universidad de Oviedo
2007-2012
Institute for Molecular Medicine Finland
2012
University of Helsinki
2012
Yale University
2012
University of Pennsylvania
2010
<ns4:p>The efficient healing of skin wounds is crucial for securing the vital barrier function skin, but pathological wound and scar formation are major medical problems causing both physiological psychological challenges patients. A number tightly coordinated regenerative responses, including haemostasis, migration various cell types into wound, inflammation, angiogenesis, extracellular matrix, involved in process. In this article, we summarise central mechanisms processes excessive...
Cancer-associated fibroblasts (CAFs) are key actors in modulating the progression of many solid tumors such as breast cancer (BC). Herein, we identify an integrin α11/PDGFRβ+ CAF subset displaying tumor-promoting features BC. In preclinical MMTV-PyMT mouse model, α11-deficiency led to a drastic reduction tumor and metastasis. A clear association between α11 PDGFRβ was found at both transcriptional histological levels BC specimens. High stromal α11/PDGFRβ expression associated with high...
Endostatin, a 20-kDa collagen XVIII fragment, inhibits angiogenesis and tumor growth in vivo, but the mechanisms are still unclear. Matrix metalloproteases (MMPs), family of extracellular membrane-associated endopeptidases, collectively digest almost all matrix basement membrane components, thus play an important role progression. We studied effects recombinant human endostatin on MMP-2, -9, -8, -13. found that inhibited activation catalytic activity pro-MMP-9 -13 as well pro-MMP-2. It...
ABSTRACT Epithelial-mesenchymal tissue interactions regulate the formation of signaling centers that play a role in coordination organogenesis, but it is not clear how their activity leads to differences organogenesis. We report type XVIII collagen, which contains both frizzled and an endostatin domain, expressed throughout respective epithelial bud at initiation lung kidney It becomes localized tips during early stages branching, while its expression confined stalk region lost from nearly...
Abstract Endostatin, a proteolytic fragment of collagen XVIII, is potent inhibitor angiogenesis and tumor growth. We studied the development carcinogen-induced skin tumors in transgenic J4 mice overexpressing endostatin their keratinocytes. Unexpectedly, we did not observe any differences incidence multiplicity between these control mice, nor rate conversion benign papillomas to malignant squamous cell carcinomas (SCC). find, however, that regulates terminal differentiation keratinocytes...
The extracellular matrix (ECM) is a major determinant of the structural integrity and functional properties myocardium in common pathological conditions, changes vasculature contribute to cardiac dysfunction. Collagen (Col) XV preferentially expressed ECM muscle microvessels.We aimed characterize ECM, cardiovascular function responses elevated load mice lacking Col (Col15a1(-/-)) define its role age- hypertension-associated myocardial remodeling.Cardiac structure were analyzed by light...
Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family proteolytic enzymes are implicated in a variety physiological processes, such as collagen maturation, organogenesis, angiogenesis, reproduction inflammation. Moreover, deficiency or overexpression certain proteins is directly involved serious human diseases, including cancer. However, functional roles other members, ADAMTS12, remain unknown. Here, by using different vitro vivo approaches, we have...
Heparan sulfate proteoglycans (HSPGs) may play a role in the formation and persistence of senile plaques neurofibrillary tangles Alzheimer's disease brains. Recently, it has been demonstrated that human extracellular matrix‐associated molecule collagen XVIII is first carrying heparan side‐chains. Two variants with both different signal peptides N‐terminal domains have described are referred to as short long form. To investigate distribution these we performed an immunohistochemical analysis...
Leukocyte infiltration during inflammation is mediated by the sequential actions of adhesion molecules and chemokines. By using a rat ureteral obstruction model, we showed previously that L-selectin plays an important role in leukocyte into kidney. Here report purification, identification, characterization L-selectin-binding heparan sulfate proteoglycan (HSPG) expressed Partial amino acid sequencing Western blotting analyses HSPG collagen XVIII, basement membrane HSPG. The binding to...
Background and aim: Aberrant angiogenesis defective epithelial repair are key features of idiopathic pulmonary fibrosis (IPF). Endostatin is an antiangiogenic peptide with known effects on endothelial cells. This study aimed to establish the levels endostatin in bronchoalveolar lavage fluid (BALF) IPF investigate its actions distal lung cells (DLEC) primary type II Methods: 20 patients 10 controls underwent BAL. was measured by ELISA. BALF cytokines matrix metalloproteinase (MMP)-3 were...
Collagens contain cryptic polypeptide modules that regulate major cell functions, such as proliferation or death. Collagen XVIII (C18) exists three amino terminal end variants with specific modules. We investigated the function of variant 3 C18 (V3C18) containing a frizzled module (FZC18), which carries structural identity extracellular cysteine-rich domain receptors. show V3C18 is surface heparan sulfate proteoglycan, its topology being mediated by FZC18 module. mRNA was expressed at low...
The turnover of extracellular matrix liberates various cryptic molecules with novel biological activity. Among these are the collagen-derived anti-angiogenic fragments, some which suggested to affect carcinoma cells also directly. Arresten is an endogenous angiogenesis inhibitor that derived from non-collagenous domain basement membrane collagen IV α1 chain. As mere prevention tumor leads hypoxia can result in selection more aggressive cell types and reduces efficacy chemotherapy, we aimed...
Significance A previously unrecognized role is described for collagen XVIII—a ubiquitous, structurally complex basement membrane proteoglycan—in supporting preadipocyte differentiation and the maintenance of this differentiated state, hence size lipid-clearing/storage functions white adipose tissue depots. Specific lack medium long isoforms nonfibrillar in mice led to reduced adiposity, ectopic deposition fat liver, elevated very low-density lipoprotein-triglyceride levels. The finding a...
The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines growth factors collectively referred as the matrisome.Studies on cancer matrisome have been performed for single or few neoplasms, but more systematic analysis is still missing.Here we present Pan-Cancer study gene expression 10,487 patients across 32 tumor types, supplemented with transcription (TFs) driver...