A5032886582- Bioinformatics and Genomic Networks
- Ubiquitin and proteasome pathways
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Protein Degradation and Inhibitors
- Sarcoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Genetics, Bioinformatics, and Biomedical Research
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Liquid Crystal Research Advancements
- Ferroptosis and cancer prognosis
- Molecular spectroscopy and chirality
- Electron Spin Resonance Studies
- 14-3-3 protein interactions
University of Oulu
1983-2021
The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines growth factors collectively referred as the matrisome.Studies on cancer matrisome have been performed for single or few neoplasms, but more systematic analysis is still missing.Here we present Pan-Cancer study gene expression 10,487 patients across 32 tumor types, supplemented with transcription (TFs) driver...
To evaluate the occurrence of mutations affecting post-translational modification (PTM) sites in matrisome genes across different tumor types, light their genomic and functional contexts comparison with rest genome.This study spans 9075 samples 32 types from The Cancer Genome Atlas (TCGA) Pan-Cancer cohort identifies 151,088 non-silent coding regions matrisome, which 1811 known hydroxylation, phosphorylation, N- O-glycosylation, acetylation, ubiquitylation, sumoylation methylation...
The expression and regulation of matrisome genes—the ensemble extracellular matrix, ECM, ECM-associated proteins regulators as well cytokines, chemokines growth factors—is paramount importance for many biological processes signals within the tumor microenvironment. availability large diverse multi-omics data enables mapping understanding regulatory circuitry governing to an unprecedented level, though such a volume information requires robust approaches analysis integration. In this study,...