A5088316594- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Management of metastatic bone disease
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Spinal Cord Injury Research
- Cervical and Thoracic Myelopathy
- Spinal Hematomas and Complications
- Nerve injury and regeneration
- Medical Imaging and Analysis
- Spondyloarthritis Studies and Treatments
- Spinal Dysraphism and Malformations
- Infectious Diseases and Tuberculosis
- Cancer-related molecular mechanisms research
- Neurofibromatosis and Schwannoma Cases
- Pelvic and Acetabular Injuries
- Orthopedic Infections and Treatments
- Musculoskeletal pain and rehabilitation
- Bone and Joint Diseases
- Cancer Treatment and Pharmacology
- Scoliosis diagnosis and treatment
- Enterobacteriaceae and Cronobacter Research
- Heme Oxygenase-1 and Carbon Monoxide
- Orthopaedic implants and arthroplasty
- Neurological Complications and Syndromes
Shimonoseki City Hospital
2025
Kyushu University
2013-2024
Osaka University
2023
Yokohama City University
2023
National Institutes of Health
2023
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2023
Spinal Injuries Center
2023
Kindai University
2023
Kyushu University Beppu Hospital
2019-2021
Kyushu University Hospital
2017
Diverse functions of microRNAs (miRNAs), including effects on tumorigenesis, proliferation, and differentiation, have been reported, several miRNAs also demonstrated to play an important role in apoptosis. In this study, we investigated the possible that may development chemoresistance Ewing sarcoma/primitive neuroectodermal tumor (EWS).We screened doxorubicin (Dox)-resistant EWS cells identify any distinct miRNA sequences regulate cells. The were evaluated using a chemosensitivity assay....
Abstract After spinal cord injury (SCI), inflammatory cells such as macrophages infiltrate the injured area, and astrocytes migrate, forming a glial scar around macrophages. The inhibits axonal regeneration, resulting in significant permanent disability. However, mechanism through which scar-forming migrate to site has not been clarified. Here we show that migrating attract reactive toward center of lesion after SCI. Chimeric mice with bone marrow lacking IRF8, controls macrophage...
Retrospective cohort study. To evaluate whether the timing of balloon kyphoplasty (BKP) affects risk adjacent vertebral fractures (AVFs) in management osteoporotic fractures. Osteoporotic are usually managed conservatively; however, complications such as nonunion, neurologic deficits, and high-grade kyphosis can arise. BKP, a minimally invasive procedure for pain relief, has been associated with AVF risk. Although meta-analyses suggest no significant difference rates between BKP conservative...
Abstract Background/Introduction: The 6-minute walk distance (6MWD) is a useful prognostic factor in patients with cardiovascular disease (CVD), but it may be challenging to assess the older populations. Usual gait speed (UGS) offer simpler alternative, direct comparisons between changes 6MWD and UGS are lacking. Purpose: This study aims examine association UGS, their value aged 75 years or CVD. Methods: We reviewed 525 CVD (≥ years) who underwent 5-month outpatient cardiac rehabilitation...
The aim of this study was to investigate the clinicopathologic features lumbar disc herniation (LDH) with endplate degeneration and association between cartilaginous fragments inflammatory response herniated disc.LDH often involves hyaline cartilage pulled from vertebral endplates. Modic changes are closely associated LDH that contains cartilage, endplates seem affect resorption disc.A total 78 patients who underwent microscopic discectomy 9 16 weeks after an occurrence were reviewed....
Neonatal spinal cord injury (SCI) shows better functional outcomes than adult SCI. Although the regenerative capability in neonatal may have cues treatment of SCI, mechanism underlying regeneration after SCI is unclear. We previously reported age-dependent variation pathogenesis inflammation Therefore, we explored differences between and mice their effect on axon outcome. established two-day-old crush as a model Immunohistochemistry revealed that nuclear translocation NF-κB, which promotes...
Tumor prostheses for the lower limb following resection of musculoskeletal tumors is useful salvage management; however, as compared with routine total joint replacement, an increased incidence deep periprosthetic infection tumor prosthesis has been observed. The risk factors remain unclear. This study examines and outcomes infection. was a retrospective observational including 121 patients (67 males 54 females) who underwent after between 1 January 2000 30 November 2018. Among prostheses, 7...
Abstract Background and objective Surgical site infection (SSI) is common in surgery for malignant musculoskeletal tumours, specifically those arising from the trunk. In this study, we investigated risk factors SSI after resection of tumours Methods This retrospective observational study included 125 patients (72 males, 53 females) with trunk our hospital 1 April 2008 to 31 August 2023. The incidence its were investigated. Results was observed 26% (32/125), median time 22 days. On...
Retrospective cohort study (level of evidence: 4).To demonstrate the effects balloon kyphoplasty (BKP) on prevention kyphosis progression.Kyphoplasty can correct local (fractured vertebra), but its efficacy is attenuated by adjacent fracture and/or disc height reduction with endplate damage. With these attenuating factors incorporated, a comparison between BKP and conservative treatment necessary to verify effect correction.This retrospectively analyzed 129 patients treated conservatively 95...
Giant cell tumors (GCTs) of bone are primary benign that characterized by a high number osteoclast-like multinuclear giant cells (MNCs). Recent studies suggest the spindle-shaped stromal in GCTs tumor cells, while monocyte-like and MNCs reactive osteoclast precursor (OPCs) osteoclasts (OCs), respectively. In this study, we investigated pathogenesis osteoclastic destruction focusing on role vascular endothelial growth factor (VEGF)-Flt-1 (type-1 VEGF receptor)-focal adhesion kinase (FAK)...
Carbon-ion radiotherapy (C-ion RT) was effective therapy for inoperable spinal and paraspinal sarcomas. However, a significant adverse event following radiotherapies is vertebral compression fractures (VCFs). In this study, we investigated the incidence of risk factors post-C-ion RT VCFs in patients with or sarcomas.Thirty consecutive sarcomas treated C-ion were retrospectively reviewed. Various clinical parameters Spinal Instability Neoplastic Score (SINS) used to evaluate VCFs.The overall...
Psoas or epidural abscesses are often accompanied by pyogenic spondylitis and require drainage. Posterolateral percutaneous endoscopic techniques usually used for hernia discectomy, but this approach is also useful in some cases of psoas lumbar ventral abscess. We here report a case that was successfully treated drainage.Our patient 57-year-old Japanese woman who had been receiving chemotherapy inflammatory breast cancer became unable to walk due lower back left leg pain. She transported as...
Retrospective study.To investigate the characteristics of newly developing Modic changes following discectomy and their impact on residual low back pain (LBP) in early postoperative stage lumbar disc herniation.We included 96 patients who underwent microscopic discectomy. Through MRI, we assessed new developments progression degeneration at surgical level. The presence cartilaginous endplates was evaluated using resected specimens, main outcome visual analog scale (VAS). Further, prevalence...
While radiotherapy is generally an acceptable treatment for metastatic spinal cord compression, surgical intervention controversial due to the invasiveness and diversity of diseases in patients being considered. The ideal treatment, therefore, depends on situation, most acute possible necessary presenting with myelopathy. We compared neurological outcomes between surgery compression myelopathy.A total 54 myelopathy treated our institution 2006 2016 were analyzed retrospectively. Twenty...
Eribulin is a new drug to treat soft tissue sarcoma (STS) that exerts antitumor activity by binding microtubules. The prognosis of STS poor, and eribulin expected improve the treatment outcome. We observed several cases exhibited resistance developed an eribulin-resistant leiomyosarcoma cell line investigate mechanism resistance. IC50 was 125 times higher in resistant than parental line, did not induce G2/M arrest cells. showed increased expression MDR1 transcript, but protein levels...
Case series.To evaluate the radiographic and clinical results of C1 laminoplasty without fusion.C1 laminectomy has been standard procedure for decompression at level. However, there have some reports trouble cases after laminectomy. might be superior to with regard maintaining original anatomical shape, preventing compression from posterior soft tissue, ensuring an adequate bonegrafting site around part if additional salvage fusion surgery is necessary afterward.Seven patients spinal cord...
Periosteal chondrosarcoma is an extremely rare malignant cartilage-forming tumour that originates from the periosteum and occurs on surface of bone. Often, it difficult to distinguish periosteal other tumours, reports in literature are scarce. This study aims investigate characteristics chondrosarcoma, focusing particularly medullary invasion. Among 33 cartilaginous seven patients with pathologically proven were identified retrospectively. The average size was 5.4 cm long axis; two tumours...
The study aimed to comprehend the clinical features and outcomes of surgical treatments for spinal disorders in patients with ankylosing spondylitis (AS).This retrospective enrolled AS who underwent spine surgery between 2000 2019 our facility.Thirteen surgeries. mean age was 56.2 years, disease duration 25.1 years at time surgery. Nine had vertebral fracture, two kyphotic deformity, myelopathy due ligament ossification. Fracture cases included five secondary pseudarthrosis/delayed palsy...
Multiple spinal cord tumors in a single patient are very rare and most often seen cases of neurofibromatosis associated disorders. Schwannomatosis, which is characterized by the development multiple schwannomas without vestibular schwannomas, has been newly defined as distinct form neurofibromatosis. The purpose present study was to describe review clinical radiological features management patients with schwannomas.Between 1986 2016, 19 schwannoma were diagnosed treated. Of patients, 13...
Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease is characterized by the accumulation of CPPD in articular and periarticular tissues, but along spinal dura mater has not been previously reported. We report a 54-year-old male presenting with progressive neck pain numbness extremities. CT showed diffuse dorsal epidural calcification from C3-T6 which resulted canal stenosis. On MR imaging, lesion was hypointense on both T1 T2 weighted images. From these findings, ligamentum...
Abstract Objective The aim of this study was to investigate the efficacy and safety tranexamic acid in patients undergoing surgery for bone soft tissue tumors. Methods Data were retrospectively collected from 454 consecutive with tumors who underwent open biopsy, marginal resection, curettage or wide resection between January 2017 December 2018. We performed propensity score matching received those did not. primary outcome variables intra-operative, peri-operative estimated blood loss (IBL,...
Abstract In crush syndrome, massive muscle breakdown resulting from ischemia–reperfusion injury can be a life-threatening condition that requires urgent treatment. Blood reperfusion into the ischemic triggers an immediate inflammatory response, and neutrophils are first to infiltrate exacerbate damage. Since free zinc ion play critical role in immune system function of is impaired by depletion, we hypothesized administration chelator would effective for suppressing reaction at site improving...