A5030664225- Ginseng Biological Effects and Applications
- Pancreatic and Hepatic Oncology Research
- Plant tissue culture and regeneration
- Genomics and Phylogenetic Studies
- Plant Molecular Biology Research
- Microbial metabolism and enzyme function
- Plant Gene Expression Analysis
- Effects of Radiation Exposure
- Lung Cancer Research Studies
- Natural product bioactivities and synthesis
- Dermatology and Skin Diseases
- Photosynthetic Processes and Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Lung Cancer Treatments and Mutations
- Plant Disease Resistance and Genetics
- Sesquiterpenes and Asteraceae Studies
- Genetic Mapping and Diversity in Plants and Animals
- Essential Oils and Antimicrobial Activity
- Phytochemistry and biological activity of medicinal plants
- Food Quality and Safety Studies
- Agriculture, Soil, Plant Science
- Cancer Cells and Metastasis
- Plant biochemistry and biosynthesis
- Transgenic Plants and Applications
- Medicinal Plants and Neuroprotection
Michigan State University
2019-2024
Seoul National University
2013-2023
Yonsei University
2012-2023
Gangnam Severance Hospital
2016-2023
National University College
2023
New Generation University College
2023
Samsung Medical Center
2015-2022
Sungkyunkwan University
2015-2022
Asan Medical Center
2022
University of Ulsan
2021-2022
Abstract Cytoplasmic chloroplast (cp) genomes and nuclear ribosomal DNA (nR) are the primary sequences used to understand plant diversity evolution. We introduce a high-throughput method simultaneously obtain complete cp nR using Illumina platform whole-genome sequence. applied 30 rice specimens belonging nine Oryza species. Concurrent phylogenomic analysis of several same AA genome species provides insight into evolution domestication cultivated rice, clarifying three ambiguous but...
Summary Panax ginseng C. A. Meyer, reputed as the king of medicinal herbs, has slow growth, long generation time, low seed production and complicated genome structure that hamper its study. Here, we unveil genomic architecture tetraploid P. by de novo assembly, representing 2.98 Gbp with 59 352 annotated genes. Resequencing data indicated diploid species diverged in association global warming Southern Asia, two North American evolved via intercontinental migrations. Two whole duplications (...
Plants respond to wounding stress by changing gene expression patterns and inducing the production of hormones including jasmonic acid. This transcriptional response activates specialized metabolism pathways such as glucosinolate in Arabidopsis thaliana. While regulatory factors sequences controlling a subset wound-response genes are known, it remains unclear how wound is regulated globally. Here, we these responses incorporating putative cis-regulatory elements, known transcription factor...
Korean ginseng (Panax C.A. Meyer) is a highly effective medicinal plant containing ginsenosides with various pharmacological activities, whose roots are produced commercially for crude drugs. Here, we used the Illumina platform to generate over 232 million RNA sequencing reads from four root samples, including whole one-year-old plants and three types of tissue six-year-old (i.e., main bodies, rhizomes, lateral roots). Through de novo assembly reference-assisted selection, obtained...
Aloe vera (Asphodeloideae) is a medicinal plant in which useful secondary metabolites are plentiful. Among the representative of anthraquinones including aloe emodin and chrysophanol, tricyclic aromatic quinones synthesized via plant-specific type III polyketide biosynthesis pathway. However, it not yet clear cellular responses can induce pathway, leading to production quinones. In this study, we examined effect endogenous elicitors on pathway identified metabolic changes induced...
The production of metabolites via in vitro culture is promoted by the availability fully defined metabolic pathways. Withanolides, major bioactive phytochemicals Withania somnifera, have been well studied for their pharmacological activities. However, only a few attempts made to identify key candidate genes involved withanolide biosynthesis. Understanding steps biosynthesis essential engineering this plant increase production. Transcriptome sequencing was performed on adventitious root and...
// Joon Seong Park 1 , Ji-hae Lee 2 Yun Sun Jae Keun Kim Seung Myung Dong Sup Yoon Pancreatobiliary Cancer Clinic, Department of Surgery, Gangnam Severance Hospital, Yonsei University, Seoul, Korea Research Institute and National Center, Goyang, Gyeonggi, Correspondence to: Dong, email: smdong@ncc.re.kr Yoon, yds6110@yuhs.ac Keywords: pancreas cancer, metastasis, EMT, LOXL2, prognosis Received: November 11, 2015 Accepted: May 04, 2016 Published: June 07, ABSTRACT Lysyl oxidase-like (LOXL2)...
Panax ginseng Meyer is a traditional medicinal plant famous for its strong therapeutic effects and serves as an important herbal medicine. To understand manipulate genes involved in secondary metabolic pathways including ginsenosides, transcriptome profiling of P. essential. RNA-seq analysis adventitious roots two cultivars, Chunpoong (CP) Cheongsun (CS), was performed using the Illumina HiSeq platform. After transcripts were assembled, expression performed. Assemblies generated from ∼85...
Ginsenosides are dammarane-type or triterpenoidal saponins that contribute to the various pharmacological activities of medicinal herb Panax ginseng. The putative biosynthetic pathway for ginsenoside biosynthesis is known in P. ginseng, as some transcripts and enzyme-encoding genes. However, few genes related UDP-glycosyltransferases (UGTs), enzymes mediate glycosylation processes final saponin biosynthesis, have been identified. Here, we generated three replicated Illumina RNA-Seq datasets...
Camelina (Camelina sativa) is an annual oilseed plant that gaining momentum as a biofuel cover crop. Understanding gene regulatory networks essential to deciphering metabolic pathways, including lipid metabolism. Here, we take advantage of growing collection expression datasets predict transcription factors (TFs) associated with the control We identified approximately 350 TFs highly co-expressed lipid-related genes (LRGs). These are represented in MYB, AP2/ERF, bZIP, and bHLH families,...
Panax ginseng C.A. Meyer is a traditional medicinal herb that produces bioactive compounds such as ginsenosides. Here, we investigated the diversity of ginsenosides and related genes among five genetically fixed inbred cultivars (Chunpoong [CP], Cheongsun [CS], Gopoong [GO], Sunhyang [SH], Sunun [SU]). To focus on genetic to ginsenoside biosynthesis, utilized in vitro cultured adventitious roots from grown under controlled environmental conditions. PCA loading plots based secondary...
Basic helix–loop–helix (bHLH) proteins are one of the largest families transcription factor (TF) in eukaryotes, and ~30% all flowering plants’ bHLH TFs contain aspartate kinase, chorismate mutase, TyrA (ACT)-like domain at variable distances C-terminal from bHLH. However, evolutionary history functional consequences bHLH/ACT-like association remain unknown. Here, we show that this is unique to plantae kingdom with green algae (chlorophytes) harboring a small number genes frequency ACT-like...
Variation in gene expression levels is pervasive among individuals and races or varieties, has substantial agronomic consequences, for example, by contributing to hybrid vigor. Gene level variation results from mutations regulatory sequences (cis) and/or transcription factor (TF) activity (trans), but the mechanisms underlying cis- trans-regulatory of complex phenotypes remain largely unknown. Here, we investigated differential accumulation insecticidal compounds maysin chlorogenic acid...
Abstract Specific protein 1 (SP1) is associated with aggressive behavior, invasive clinical phenotype and poor outcomes in various cancers. We studied whether SP1 exerts its effect on invasiveness promotion of the epithelial-mesenchymal transition (EMT) by regulating lysyl oxidase-like 2 (LOXL2) pancreatic ductal adenocarcinoma (PDAC) cell lines. showed that silencing MIA Paca-2 significantly decreased invasion migration. In cells, induced a reduction LOXL2 expression, whereas did not lead...
Abstract Anthocyanin pigments furnish a powerful visual output of the stress and metabolic status Arabidopsis thaliana plants. Essential for pigment accumulation is TRANSPARENT TESTA19 (TT19), glutathione S -transferase proposed to bind stabilize anthocyanins, participating in their vacuolar sequestration, function conserved across flowering Here, we report identification genetic suppressors that result anthocyanin absence TT19. We show mutations RDR6 , SGS3 or DCL4 suppress defect tt19 by...
Background: Although muscles and bones interact with each other through various secretory factors, the role of sclerostin, an osteocyte-secreted factor, on muscle metabolism has not been well studied. We investigated levels serum sclerostin in Korean older adults sarcopenia.Methods: Blood samples were collected from 129 participants who underwent evaluation mass function outpatient geriatric clinic a teaching hospital. Sarcopenia related parameters determined using cutoff values for Asian...
Salicylic acid was recently formulated in a hydroethanolic vehicle at concentration of 20% to 30%. has strong comedolytic effects because its lipophilic nature.To compare the therapeutic efficacy and tolerability salicylic peels with those Jessner's solution patients acne vulgaris.Thirteen (13 men; mean age 22.6, range 20-28) facial were enrolled. applied one side each patient's face 30% other three sessions 2-week intervals. A blinded investigator counted noninflammatory inflammatory...
Pancreatic ductal adenocarcinoma (PDAC) is a type of cancer with high morbidity and mortality rates worldwide. Owing to lack therapeutic options, the overall survival rate patients pancreatic low. Gemcitabine has been mainly used treat cancer, but its efficacy limited by chemoresistance. Therefore, novel agent for PDAC therapy urgently needed. An anthelminthic drug, niclosamide, already researched in breast, lung, colon, as an anti-cancer purpose re-positioning original purpose. However,...
BACKGROUND Although office-based dermatologic procedures are generally considered safe, there is a lack of prospective data on the rate adverse events (AEs) associated with these procedures. OBJECTIVE To determine frequency AEs after surgery and to characterize most commonly encountered AEs. METHODS A web-based interface was designed track input four surgeons. Patient demographic operative were collected at time procedure. occurring any during collection period logged according an priori...
Abstract Atopic dermatitis ( AD ) is a highly pruritic, chronic relapsing inflammatory skin disease characterized by innate and adaptive immune reactions. In , mechanisms such as pattern recognition receptors antimicrobial peptides have been investigated in detail, but recently, epidermis‐derived cytokines, namely thymic stromal lymphopoietin TSLP ), IL ‐25 ‐33, were shown to participate reactions independently of immunity. addition conventional cells, mast basophils eosinophils, T h2...