A5035377712- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Microscopic Colitis
- Fungal and yeast genetics research
- Inflammatory Bowel Disease
- Software Engineering Techniques and Practices
- Microbial Metabolic Engineering and Bioproduction
- RNA and protein synthesis mechanisms
- Advanced Text Analysis Techniques
- Plant biochemistry and biosynthesis
- Eosinophilic Esophagitis
- Infective Endocarditis Diagnosis and Management
- Lymphoma Diagnosis and Treatment
- Infectious Aortic and Vascular Conditions
- Helicobacter pylori-related gastroenterology studies
- Team Dynamics and Performance
- Salmonella and Campylobacter epidemiology
- Microbial Metabolism and Applications
- Phytochemistry and Bioactivity Studies
- Healthcare cost, quality, practices
- Natural Antidiabetic Agents Studies
- Viral gastroenteritis research and epidemiology
- Immune cells in cancer
University of California, San Diego
2023-2024
Carilion Clinic
2021-2023
Virginia Tech
2021-2023
Carilion Roanoke Memorial Hospital
2021
University Hospitals of Cleveland
2021
Hallym University
2017-2019
Northwestern University
2019
Korea Research Institute of Bioscience and Biotechnology
2018
Hallym Polytechnic University
2017
Isoprene is a valuable precursor for synthetic rubber and signature product of terpenoid pathways. Here, we developed an isoprene biosensor by employing TbuT transcriptional regulator Ralstonia pickettii to express fluorescent reporter gene in response intracellular engineered Escherichia coli. The recognizes as its less-preferred effector molecule; thus, amplified the expression using T7 RNA polymerase-mediated cascade iteratively tuned promoter transcribing tbuT improve sensitivity...
For some inducible genes, the rate and molecular mechanism of transcriptional activation depend on prior experiences cell. This phenomenon, called epigenetic memory, accelerates reactivation, requires both changes in chromatin structure recruitment poised RNA polymerase II (RNAPII) to promoter. Memory inositol starvation budding yeast involves a positive feedback loop between transcription factor-dependent interaction with nuclear pore complex histone H3 lysine 4 dimethylation (H3K4me2)....
The polysaccharide component of Angelica gigas induces immuno-stimulatory effects on innate immune cells. However, it is unclear whether A. gigas' adjuvant activity the system can elicit anti-cancer responses.A water-soluble was prepared. How this ISAg modulated activation cells such as dendritic (DCs) examined. ISAg-induced cytotoxic via natural killer (NK) and NKT also tested using a tumor-bearing mouse model.ISAg treatment induced nitric oxide (NO) production cytokine gene expression...
Kaempferol-3-O-β-d-glucopyranoside (astragalin, AS), a major flavonoid that exists in various plants, exerts antioxidant, antitumor, anti-human immunodeficiency virus (HIV), and anti-inflammatory effects. However, the low water solubility of AS limits its use. In this study, we used cyclodextrin glucanotransferase (CGTase) with maltose (G2) as donor molecule to enzymatically modify improve physiochemical properties. We isolated glycosylated astragalin (G1-AS) identified structure G1-AS...
Multidisciplinary teams (MDT) aid the diagnosis and management of patients with inflammatory bowel disease (IBD) improve patient outcomes. The direct impact a gastrointestinal expert pathologist on MDT care IBD is unknown.
We recently demonstrated that the polysaccharide component of Korean medicinal herb Angelica gigas (immuno-stimulatory fraction A. gigas; ISAg) induces anticancer effects in mice by activating natural killer (NK) and T (NKT) cells. However, it is unclear whether use ISAg vivo can affect differentiation conventional Here, we investigated on activation CD4+ CD8+ found administration induced polarization cells toward acquisition Th1 phenotype vivo. Additionally, treated with ISAg, produced more...
Typhoid fever is an infectious febrile illness caused by Salmonella typhi that rare in the United States but endemic regions of South Asia and Africa. initially presents with nonspecific symptoms such as fever, malaise, abdominal pain. We describe a case typhoid adult recent travel to Mexico. After presentation, patient developed Faget sign computed tomography (CT) abdomen revealed mesenteric adenitis, which prompted additional workup. Diagnosis was established blood culture treated ciprofloxacin.
For a human-like chatbot, constructing long-term memory is crucial. A naive approach for making could be simply listing the summarized dialogue. However, this can lead to problems when speaker's status change over time and contradictory information gets accumulated. It important that stays organized lower confusion response generator. In paper, we propose novel scheme conversation, CREEM. Unlike existing approaches construct based solely on current sessions, our proposed model blending past...
Large language models (LLMs) are capable of processing lengthy dialogue histories during prolonged interaction with users without additional memory modules; however, their responses tend to overlook or incorrectly recall information from the past. In this paper, we revisit memory-augmented response generation in era LLMs. While prior work focuses on getting rid outdated memories, argue that such memories can provide contextual cues help systems understand development past events and,...
Mucosa-associated lymphoid tissue (MALT) lymphoma is a common cause of gastric lymphoma. Although most cases are associated with an H. pylori infection, approximately 10% pylori-negative. Patients MALT usually asymptomatic or present nonspecific symptoms such as abdominal pain, dyspepsia, weight loss, and occult gastrointestinal bleeding. In this report, we describe two patients pylori-negative who both presented acute upper bleeding that led to hemodynamic instability. After resuscitation,...
Eosinophilic gastroenteritis (EG) is an autoimmune disorder that involves infiltration of eosinophils in the bowel wall stomach and/or intestine, resulting various gastrointestinal symptoms. The majority cases are diagnosed by findings increased on mucosal biopsies. We describe a rare type eosinophilic with involving only muscularis propria layer. This elusive diagnosis was made after full-thickness intestinal biopsy. predominantly muscular can cause obstruction or perforation. Similar to...