A5077895107- Biofuel production and bioconversion
- Fungal and yeast genetics research
- Microbial Metabolic Engineering and Bioproduction
- Bacteriophages and microbial interactions
- Cancer Research and Treatments
- Catalysis for Biomass Conversion
- Salmonella and Campylobacter epidemiology
- Biomedical and Engineering Education
- Genomics and Chromatin Dynamics
- Entrepreneurship Studies and Influences
- RNA Research and Splicing
- Interdisciplinary Research and Collaboration
- Enzyme Catalysis and Immobilization
- Viral gastroenteritis research and epidemiology
Northwestern University
2019-2023
University of California, Berkeley
2014-2015
Sustainable biofuel production from renewable biomass will require the efficient and complete use of all abundant sugars in plant cell wall. Using cellulolytic fungus Neurospora crassa as a model, we identified xylodextrin transport consumption pathway required for its growth on hemicellulose. Reconstitution this utilization Saccharomyces cerevisiae revealed that fungal xylose reductases act reductases, producing xylosyl-xylitol oligomers metabolic intermediates. These intermediates are...
Economical production of fuels and chemicals from plant biomass requires the efficient use sugars derived cell wall. Neurospora crassa, a model lignocellulosic degrading fungus, is capable breaking down complex structure In addition to cellulases hemicellulases, N. crassa secretes lytic polysaccharide monooxygenases (LPMOs), which cleave cellulose by generating oxidized sugars—particularly aldonic acids. However, strategies employs utilize these are unknown. We identified an acid utilization...
Abstract Sustainable biofuel production from renewable biomass will require the efficient and complete use of all abundant sugars in plant cell wall. Using cellulolytic fungus Neurospora crassa as a model, we identified xylodextrin transport consumption pathway required for its growth on hemicellulose. Successful reconstitution this utilization Saccharomyces cerevisiae revealed that fungal xylose reductases act reductases, together with two hydrolases, generate intracellular xylitol....
Abstract Proteins comprise a multibillion-dollar industry in enzymes and therapeutics, but bacterial protein production can be costly inefficient. of interest (POIs) must extracted from lysed cells, purified, resolubilized. The Salmonella pathogenicity island 1 type III secretion system (T3SS) is complex that has been engineered to secrete heterologous proteins addresses the problems associated with production. However, current best practices method T3SS pathway activation for not ideal...
The U.S. bioeconomy is rapidly expanding and expected to open the door over a million jobs by 2030. Experiential learning, also known as “learning doing”, critical component of education training for workers entering bioeconomy. To prepare students with skills they need succeed in workforce, we recommend that NSF create center develop experiential learning opportunities biotechnology biomanufacturing four-year undergraduate degree programs. These recommendations include prioritizing...