A5009916028- Inflammatory Bowel Disease
- Diverticular Disease and Complications
- Microscopic Colitis
- Gastric Cancer Management and Outcomes
- Clostridium difficile and Clostridium perfringens research
- Lymphoma Diagnosis and Treatment
- Gut microbiota and health
- Neutropenia and Cancer Infections
- Food Allergy and Anaphylaxis Research
- Gastroesophageal reflux and treatments
- Blood disorders and treatments
- Colorectal and Anal Carcinomas
- Allergic Rhinitis and Sensitization
- Mycobacterium research and diagnosis
- Abdominal vascular conditions and treatments
- Liver Disease Diagnosis and Treatment
- Chemokine receptors and signaling
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal disorders and treatments
- Colorectal Cancer Surgical Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Appendicitis Diagnosis and Management
- Colorectal Cancer Screening and Detection
- Galectins and Cancer Biology
- Pancreatitis Pathology and Treatment
RELX Group (Netherlands)
2023
Atrium Medical Cente
2023
Carilion Clinic
2019-2022
Virginia Tech
2019-2022
University of Virginia
2015-2017
University of Virginia Health System
2016
Virginia Gastroenterology Institute
2015
University of Virginia Medical Center
2015
Vanderbilt University Medical Center
2013
Accurate and high-throughput technologies are needed for identification of new therapeutic targets optimizing therapy in inflammatory bowel disease. Our aim was to assess multi-analyte protein-based assays cytokines/chemokines using Luminex technology. We have reported that Luminex-based profiling useful assessing response L-arginine the mouse model dextran sulfate sodium colitis. Therefore, we studied prospectively collected samples from ulcerative colitis (UC) patients control subjects....
Introduction: Acute pancreatitis (AP) is a severe inflammatory condition capable of causing local and systemic complications. Splanchnic vein thrombosis complicates up to 10% AP. Clinicians advise anticoagulation (AC) in some patients developing portal (PVT) and/or acute splenic (SpVT) following AP, but evidence-based guidelines are lacking. We aim compare the rate gastrointestinal (GI) bleeding, thrombus resolution, 90-day mortality between who did not receive AC setting AP concomitant PVT...
BACKGROUNDPatients with ulcerative colitis (UC) may be exposed to opioids over their disease duration.The use of such medications carries significant risk, including intestinal dysmotility and potential for addiction.However, the rates narcotic misuse in patients UC have not been studied extensively.Functional gastrointestinal disorders (FGID) are prevalent UC, shown increase risk Crohn's disease.We hypothesized that a concurrent diagnosis FGID would increased both opioid our patient cohort....
Mammalian meat allergy is an IgE antibody-mediated response to a mammalian oligosaccharide epitope galactose-α-1,3-galactose (alpha-gal). Anaphylaxis may occur after patients bitten by lone star tick develop antibodies alpha-gal and are re-exposed the same following ingestion of products such as beef, pork, lamb. Severe anaphylaxis monoclonal glycosylated with (i.e., cetuximab) has been reported in this patient population. We present case first dose IgE-mediated allergic reaction infliximab...
Introduction: The stomach is a common extra-nodal organ affected by mucosa-associated lymphoid tissue (MALT) lymphoma. About 10% of cases are Helicobacter pylori-negative. We present 2 such in whom radiotherapy was pursued. Case Description/Methods: A 73 yo female with PMH sick sinus syndrome s/p pacemaker placement and anxiety presented generalized weakness post-prandial abdominal pain associated near-syncope, nausea melena. She denied NSAID abuse, smoking cigarettes, anticoagulation,...
A 65-year-old woman presented with three days of colicky abdominal pain. Abdominal imaging illustrated small bowel enteritis, ascites in both paracolic gutters, and incidental hepatic steatosis. Although fluid demonstrated high neutrophil count consistent peritonitis the patient received adequate antibiotics, she clinically deteriorated. Subsequent exploratory laparotomy revealed necrotic appendix multiple intra-abdominal abscesses. Histopathology showed acute suppurative appendicitis other...
Introduction: Gastroenterologists are often consulted for diagnostic endoscopy in neutropenic patients. However, there is limited data on the safety and yield of patients with severe neutropenia (absolute neutrophil count ≤500 cells/μL). Often these procedures performed to manage gastrointestinal bleeding or identify opportunistic infection, mucositis, GVHD. While complications rare general population, many gastroenterologists have concerns about Methods: This retrospective review identified...
Introduction:Clostridium difficile infection (CDI) is increasingly burdensome to our healthcare system, accounting for nearly 500,000 cases and 29,000 deaths in the US 2011. Identifying predictors of severity CDI critical instituting appropriate initial therapy. The presence nucleated red blood cells (NRBCs) has not been investigated before. NRBCs, a poor prognostic sign illness, are attributed elevations erythropoietin, IL-3, IL-6. detectable NRBCs associated with higher risk in-hospital...
Clostridium difficile infection (CDI) in immunosuppressed individuals is associated with high rates of recurrence, complications, and mortality. Fecal microbiota transplantation (FMT) has shown promising results this population, including an overall cure rate 88% one study, but the potential for serious adverse events FMT deserves careful consideration. A 66-year-old female recurrent infections secondary to chronic neutropenia from Shwachman-Diamond syndrome (SDS) was admitted ICU third time...
Mucosa-associated lymphoid tissue (MALT) lymphoma is a common cause of gastric lymphoma. Although most cases are associated with an H. pylori infection, approximately 10% pylori-negative. Patients MALT usually asymptomatic or present nonspecific symptoms such as abdominal pain, dyspepsia, weight loss, and occult gastrointestinal bleeding. In this report, we describe two patients pylori-negative who both presented acute upper bleeding that led to hemodynamic instability. After resuscitation,...
Introduction: Obesity is a global epidemic and condition which can lead to development of chronic illnesses such as diabetes, cardiovascular disease, cancer, has also been proposed risk factor for complications inflammatory bowel diseases (IBD) Crohn’s disease (CD) ulcerative colitis. In patients with CD, more than 70% require surgery due stricturing and/or penetrating complications, the endoscopic recurrence within five years high 60-90%. not studied extensively postoperative (POR) CD. We...
Introduction: Distinguishing Crohn’s disease (CD) from ulcerative colitis (UC) may be difficult when the is limited to colon. The aim of this study was examine role endoscopic ultrasound (EUS) in diagnosing CD versus UC and monitoring activity. Methods: Adults with colonic involvement, UC, controls who were undergoing colonoscopy evaluate gastrointestinal symptoms or screen for colon cancer 2019-2021 at a tertiary care center prospectively recruited. Patients active colorectal cancer,...