David L. Carr‐Locke

ORCID: 0000-0003-1931-714X
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About
Contact & Profiles
Research Areas
  • Gallbladder and Bile Duct Disorders
  • Esophageal and GI Pathology
  • Pancreatic and Hepatic Oncology Research
  • Pediatric Hepatobiliary Diseases and Treatments
  • Pancreatitis Pathology and Treatment
  • Gastrointestinal disorders and treatments
  • Gastric Cancer Management and Outcomes
  • Biliary and Gastrointestinal Fistulas
  • Gastroesophageal reflux and treatments
  • Gastrointestinal Bleeding Diagnosis and Treatment
  • Gastrointestinal Tumor Research and Treatment
  • Colorectal Cancer Screening and Detection
  • Metastasis and carcinoma case studies
  • Bariatric Surgery and Outcomes
  • Eosinophilic Esophagitis
  • Dysphagia Assessment and Management
  • Esophageal Cancer Research and Treatment
  • Body Contouring and Surgery
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Diverticular Disease and Complications
  • Tracheal and airway disorders
  • Helicobacter pylori-related gastroenterology studies
  • Liver Disease Diagnosis and Treatment
  • Liver Disease and Transplantation
  • Lung Cancer Diagnosis and Treatment

New York Hospital Queens
2010-2025

NewYork–Presbyterian Hospital
2010-2025

Presbyterian Hospital
2017-2025

Weill Cornell Medicine
2018-2025

Cornell University
2017-2025

Digestive Care (United States)
2017-2023

Texas Health Dallas
2021

Penn Presbyterian Medical Center
2021

University of Missouri Health System
2020

Brigham and Women's Hospital
2003-2019

Confocal laser endomicroscopy (pCLE) provides real-time histologic imaging of human tissues at a depth 60-70 μm during endoscopy. pCLE the extrahepatic bile duct after fluorescein injection demonstrated reticular pattern within fluorescein-filled sinuses that had no known anatomical correlate. Freezing biopsy tissue before fixation preserved anatomy this structure, demonstrating it is part submucosa and previously unappreciated fluid-filled interstitial space, draining to lymph nodes...

10.1038/s41598-018-23062-6 article EN cc-by Scientific Reports 2018-03-15

Confocal laser endomicroscopy (CLE) is rapidly emerging as a valuable tool for gastrointestinal endoscopic imaging. Fluorescent contrast agents are used to optimize imaging with CLE, and intravenous fluorescein the most widely agent. Fluorescein FDA-cleared diagnostic angiography of retina. For these indications, safety profile has been well-documented; however, date, not cleared use CLE.To estimate rate serious total adverse events attributable when CLE.We performed cross sectional survey...

10.1111/j.1365-2036.2009.04207.x article EN Alimentary Pharmacology & Therapeutics 2009-11-30

Recent reports suggest that prevalence of gastrointestinal (GI) and hepatic manifestations in COVID-19 are higher than initially reported, particularly Western populations. New York City has arguably been the epicenter pandemic United States, creating a unique opportunity to further understanding this disease. Our objectives were investigate GI patients with COVID-19, explore their effect on clinical outcomes these patients. This is retrospective review consecutive adult (age ≥18) positive...

10.1053/j.gastro.2020.05.010 article EN other-oa Gastroenterology 2020-05-08

One hundred and twenty patients with known common bile duct stones were entered into a prospective randomised study of preoperative endoscopic sphincterotomy stone clearance (group 1) versus surgery alone 2). Five incorrectly entered; the 55 to group 1 60 2 well matched respect clinical features biochemical medical risk factors. In was successful in 50 (91%); five these refused elective surgery, though this subsequently necessary one. cleared surgically 54 59 (91.5%); one patient treated by...

10.1136/bmj.294.6570.470 article EN BMJ 1987-02-21

The indications and results of 394 endoscopic sphincterotomies (ES) performed over a 6 year period from single centre are described. for ES were common bile duct (CBD) calculi (81 per cent), papillary stenosis (9 periampullary tumours, insertion endoprostheses, sump syndrome biliary dilatation benign strictures. was achieved in 98 cent patients. In the calculus group CBD cleared stones 93.3 following successful (92 overall success rate clearance). Early complications (less than or equal to 1...

10.1002/bjs.1800720325 article EN British journal of surgery 1985-03-01

Ninety-four patients admitted to Leicester Hospitals with acute cholangitis since 1977 were reviewed coincide the availability of endoscopic sphincterotomy (ES). Thirty-four men and sixty women, their mean age was 69.7 years median hospital stay 20 days. There 15 deaths (16 per cent) by 30 days in significantly lower initial serum albumin levels (P less than 0.005) higher urea 0.05) survivors. Eighty-two had common bile duct (CBD) calculi whom 71 underwent early decompression biliary tree...

10.1002/bjs.1800731214 article EN British journal of surgery 1986-12-01

There are few data in the literature regarding indications, therapy, and safety of endoscopic management pancreatico-biliary disorders during pregnancy. We report largest single center experience with ERCP pregnancy.We reviewed 15 patients that underwent In all patients, pelvis was lead-shielded fetus monitored by an obstetrician. Fluoroscopy minimized hard copy radiographs taken only when essential.The mean patient age 28.9 yr (15-36 yr). The duration gestation 25 wk (12-33 wk); one first,...

10.1111/j.1572-0241.2003.07261.x article EN The American Journal of Gastroenterology 2003-02-01

The integrity of the main pancreatic duct (MPD) was evaluated by endoscopic retrograde pancreatography (ERP) in a retrospective study 105 patients with acute pancreatitis presenting over an 11-year period (1980-1991). findings were compared clinical outcome and need to operate for local complications. Patients divided into two groups. Group 1 (n = 89) had either clinically mild or severe disease but no surgery complications, < 25 per cent necrosis on contrast-enhanced computed tomography...

10.1002/bjs.1800800131 article EN British journal of surgery 1993-01-01
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