A5017325799- interferon and immune responses
- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- Immune Response and Inflammation
- Respiratory viral infections research
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Cytomegalovirus and herpesvirus research
- RNA regulation and disease
- Cell death mechanisms and regulation
- Viral gastroenteritis research and epidemiology
Nanjing Agricultural University
2021-2025
Huazhong Agricultural University
2018-2020
The current coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), highlights major gaps in our knowledge on the prevention control and cross-species transmission mechanisms of animal coronaviruses. Transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea (PEDV), delta (PDCoV) are three common swine coronaviruses have similar clinical features. In absence effective treatments, they led to significant economic losses industry...
Alphaviruses threaten public health continuously, and Getah virus (GETV) is a re-emerging alphavirus that can potentially infect humans. Approved antiviral drugs vaccines against alphaviruses are few available, but several host factors have been reported. Here, we used GETV as model of to screen for additional factors. Tetrachlorodibenzo-p-dioxin-inducible poly(ADP ribose) polymerase was identified inhibit replication by inducing ubiquitination the glycoprotein E2, causing its degradation...
Abstract Various low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes determined. Here, we analyze similarities differences in receptor binding modes multiple alphaviruses to understand their ability infect a wide range hosts. We further discuss challenges associated with development broad-spectrum treatment strategies against diverse alphaviruses.