A5000593090- Spaceflight effects on biology
- Medical and Biological Ozone Research
- Antimicrobial Resistance in Staphylococcus
- Obstructive Sleep Apnea Research
- Antibiotic Use and Resistance
- High Altitude and Hypoxia
- Neuroscience of respiration and sleep
- Tracheal and airway disorders
- Optical Imaging and Spectroscopy Techniques
- Gut microbiota and health
- Respiratory Support and Mechanisms
University of Malta
2022-2024
Mater Dei Hospital
2017
Maintenance of astronaut health during spaceflight will require monitoring and potentially modulating their microbiomes. However, documenting microbial shifts has been difficult due to mission constraints that lead limited sampling profiling. Here we executed a six-month longitudinal study quantify the high-resolution human microbiome response three days in orbit for four individuals. Using paired metagenomics metatranscriptomics alongside single-nuclei immune cell profiling, characterized...
Continuous positive airway pressure (CPAP) is the standard treatment for obstructive sleep apnoea (OSA), with limited data about prevalence of respiratory infections and microbial colonization in these patients.The aim this study was to determine if CPAP use associated identify organisms that colonize or infect patients.A retrospective, case-controlled patients diagnosed OSA carried out. 137 were recruited interviewed using a questionnaire. A nasal swab taken from each patient. Patients...
<title>Abstract</title> Maintenance of astronaut health during spaceflight will require monitoring and potentially modulating their microbiomes, which play a role in some space-derived disorders. However, documenting the response microbiota to has been difficult thus far due mission constraints that lead limited sampling. Here, we executed six-month longitudinal study centered on three-day flight quantify high-resolution microbiome spaceflight. Via paired metagenomics metatranscriptomics...
The purpose of the Maleth Program, also known as Project Maleth, is Malta's first space program to evaluate human skin tissue microbiome changes in type 2 diabetes mellitus (T2DM) patients afflicted with diabetic foot ulcers (DFU). This was carried out both ground-based models and spaceflight. mission (Maleth I) under this uncover effects spaceflight, microgravity radiation on samples from six T2DM recruited into study. Each patient sample split three, one section processed immediately for...
Since the 1960’s, meticillin-resistant Staphylococcus aureus (MRSA) has become a major pathogen with ever-increasing incidence rates of hospital-acquired and community-acquired infections. Malta currently one highest infections in Europe. In addition, reports have estimated community carriage at more than 8%. MRSA homes for elderly is very important because these residents are often hospitalized therefore serve as source transmission. The aims this study were to establish prevalence nasal...
The first mission (Maleth I) forms part of Project Maleth and aims to uncover the effects spaceflight, microgravity radiation on human skin tissue microbiome samples from six Type 2 Diabetes Mellitus diabetic foot ulcers (DFU). intended highlight some very best frontier research programs in Malta that capitalized unique spectra medical, life, health sciences power collaborative using multiple tools answer question. I’s overall objective was achieved specimens conducted space back yielded...
Since the 1960’s, meticillin-resistant Staphylococcus aureus (MRSA) has become a major pathogen with ever-increasing incidence rates of hospital-acquired and community-acquired infections. Malta currently one highest infections in Europe. In addition, reports have estimated community carriage at more than 8%. MRSA homes for elderly is very important because these residents are often hospitalized therefore serve as source transmission. The aims this study were to establish prevalence nasal...
The first mission (Maleth I) forms part of Project Maleth and aims to uncover the effects spaceflight, microgravity radiation on human skin tissue microbiome samples from six Type 2 Diabetes Mellitus diabetic foot ulcers (DFU). intended highlight some very best frontier research programs in Malta that capitalized unique spectra medical, life, health sciences power collaborative using multiple tools answer question. I’s overall objective was achieved specimens conducted space back yielded...