A5047406947- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Photoreceptor and optogenetics research
- Mechanisms of cancer metastasis
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- Digestive system and related health
- Phagocytosis and Immune Regulation
- Renal and related cancers
- Pancreatitis Pathology and Treatment
- Cancer Research and Treatments
- Immune cells in cancer
- Renin-Angiotensin System Studies
- NF-κB Signaling Pathways
- Click Chemistry and Applications
- FOXO transcription factor regulation
- interferon and immune responses
- Pluripotent Stem Cells Research
- Hormonal Regulation and Hypertension
- Reproductive System and Pregnancy
Merus (Netherlands)
2025
Cornell University
2019-2024
Weill Cornell Medicine
2019-2024
Memorial Sloan Kettering Cancer Center
2017
de Duve Institute
2012-2014
Institut Cochin
2010
Inserm
2009-2010
Centre National de la Recherche Scientifique
2008-2009
Sorbonne Université
2008-2009
Université Paris Cité
2008
<h3>Objective</h3> Growing evidence suggests that a phenotypic switch converting pancreatic acinar cells to duct-like can lead intraepithelial neoplasia and eventually invasive ductal adenocarcinoma. Histologically, the onset of this is characterised by co-expression markers in acini, lesion called acinar-to-ductal metaplasia (ADM). The transcriptional regulators required initiate ADM are unknown, but need be identified characterise regulatory networks drive ADM. In study, role transcription...
The COVID-19 pandemic has caused significant mortality and morbidity around the world. Although effective vaccines have been developed, large parts of world remain unvaccinated while new SARS-CoV-2 strains keep emerging.
Abstract Nerves are a notable feature of the tumor microenvironment in some epithelial tumors, but their role malignant progression pancreatic ductal adenocarcinoma (PDAC) is uncertain. Here, we identify dense innervation precancerous lesions, known as intraepithelial neoplasms (PanIN), and describe unique subpopulation neuroendocrine PanIN cells that express neuropeptide substance P (SP) receptor neurokinin 1-R (NK1-R). Using organoid culture, demonstrated sensory neurons promoted...
<h3>Objective</h3> The transcription factor SOX9 was recently shown to stimulate ductal gene expression in pancreatic acinar-to-ductal metaplasia and accelerate development of premalignant lesions preceding adenocarcinoma (PDAC). Here, we investigate how operates tumourigenesis. <h3>Design</h3> We analysed genomic transcriptomic data from surgically resected PDAC extended the analysis xenografts samples cell lines. manipulated human lines mouse models developing PDAC. <h3>Results</h3> found...
Nerves are a notable feature of the tumor microenvironment in some epithelial tumors, but their role malignant progression pancreatic ductal adenocarcinoma (PDAC) is uncertain. Here, we identify dense innervation precancerous lesions, known as intraepithelial neoplasms (PanIN), and describe unique subpopulation neuroendocrine PanIN cells that express neuropeptide substance P (SP) receptor neurokinin 1-R (NK1-R). Using organoid culture, demonstrated sensory neurons promoted proliferation...
Abstract Inflammation in the context of pancreatic injury drives acinar-to-ductal metaplasia (ADM), a cell state that can be hijacked by mutant Kras to drive formation cancer. ADM has been described alternatively bear progenitor features, but extent which lineage reversion is broad feature response and early tumorigenesis - particularlyacross different alleles remains poorly understood. Herein we implement novel Ptf1a-tdTomato mice characterize late progenitors serve as benchmarks define...
Renal functions are regulated by steroid sex hormones, but the exhaustive identification of their receptors along nephron is still lacking. Here, we have localized all known nuclear or membrane‐bound hormone and some activators male female mice. Almost present in kidney, them having very restricted localization. Only one gene tested among 11 (ARA54) exhibits a gender difference level its expression. This first “renal map” receptor expression may serve as pre‐requisite for investigating role...
SUMMARY Inflammation is essential to the disruption of tissue homeostasis, and, in pancreas, can destabilize identity terminally differentiated acinar cells. Herein we employ lineage-traced mouse models delineate chromatin dynamics that accompany cycle metaplasia and regeneration following pancreatitis, unveil presence an epigenetic memory inflammation pancreatic cell compartment. We observe despite histologic resolution cells fail return their molecular baseline after several months,...
Abstract The transcription factor SOX9 has recently been shown to have a role in the ontogenesis of pancreatic ductal adenocarcinoma (PDAC) through metaplastic changes acinar cells. Nevertheless, mechanisms which operates remain be explored. We analyzed genomic and transcriptomic data from cohort surgically resected cases PDAC (n=90) Australian Pancreatic cancer Genome Initiative (APGI). Genetic aberrations (mutation copy number changes) gene were found 15% patient tumors. Protein expression...
<div>Abstract<p>Nerves are a notable feature of the tumor microenvironment in some epithelial tumors, but their role malignant progression pancreatic ductal adenocarcinoma (PDAC) is uncertain. Here, we identify dense innervation precancerous lesions, known as intraepithelial neoplasms (PanIN), and describe unique subpopulation neuroendocrine PanIN cells that express neuropeptide substance P (SP) receptor neurokinin 1-R (NK1-R). Using organoid culture, demonstrated sensory neurons...
<p>3D animation showing innervation of a PanIN lesion.</p>
<p>Bright field and fluorescent live imaging of NK1-Rlow (red) NK1-Rhi/GFP (yellow) cells plated together in organoid culture.</p>
<div>Abstract<p>Nerves are a notable feature of the tumor microenvironment in some epithelial tumors, but their role malignant progression pancreatic ductal adenocarcinoma (PDAC) is uncertain. Here, we identify dense innervation precancerous lesions, known as intraepithelial neoplasms (PanIN), and describe unique subpopulation neuroendocrine PanIN cells that express neuropeptide substance P (SP) receptor neurokinin 1-R (NK1-R). Using organoid culture, demonstrated sensory neurons...
<p>Contains the figure legends for supplemental Figures S1-S8, Table S1 and Videos V1 V2.</p>
<p>Figure S1 (Supports Figures 1 and 3) Co-culture of DRG neurons with cell organoid lines. Figure S2 6) Histopathologic techniques for PanIN quantification tumor identification. S3 4) FACS sorting neuroendocrine cells expansion in culture. S4 1) Innervation wild type pancreas PanIN-free acinar tissue axon recruitment by PDAC S5 2) Mouse human PanINs contain NK1-R+ cells. S6 Human duodenal enteroendocrine express the NK1-R. S7 organoids CgA neuronal conditioned media increases...
<p>Figure S1 (Supports Figures 1 and 3) Co-culture of DRG neurons with cell organoid lines. Figure S2 6) Histopathologic techniques for PanIN quantification tumor identification. S3 4) FACS sorting neuroendocrine cells expansion in culture. S4 1) Innervation wild type pancreas PanIN-free acinar tissue axon recruitment by PDAC S5 2) Mouse human PanINs contain NK1-R+ cells. S6 Human duodenal enteroendocrine express the NK1-R. S7 organoids CgA neuronal conditioned media increases...
<p>List of target genes and their respective primer sequences used in qPCR analyses.</p>