A5072657062- HIV-related health complications and treatments
- HIV Research and Treatment
- Bone and Joint Diseases
- Vitamin D Research Studies
- COVID-19 Clinical Research Studies
- Bone health and treatments
- Mitochondrial Function and Pathology
- HIV/AIDS drug development and treatment
- Diet and metabolism studies
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Dermatological and COVID-19 studies
- Autophagy in Disease and Therapy
- SARS-CoV-2 and COVID-19 Research
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Long-Term Effects of COVID-19
- Bone health and osteoporosis research
- Ferroptosis and cancer prognosis
- Inflammasome and immune disorders
- Phagocytosis and Immune Regulation
- COVID-19 and healthcare impacts
- Tryptophan and brain disorders
- Congenital heart defects research
Rush University Medical Center
2021-2025
Children's Hospital of Philadelphia
2023-2025
To determine the effects of SARS-CoV-2 infection on cellular metabolism, we conducted an exhaustive survey metabolic pathways modulated by and confirmed their importance for propagation cataloging specific pathway inhibitors. This revealed that strongly inhibits mitochondrial oxidative phosphorylation (OXPHOS) resulting in increased reactive oxygen species (mROS) production. The elevated mROS stabilizes HIF-1α which redirects carbon molecules from oxidation through glycolysis pentose...
Mitochondrial DNA (mtDNA) is highly polymorphic, and host mtDNA variation has been associated with altered cancer severity. To determine the basis of this mtDNA–cancer association, we analyzed conplastic mice C57BL/6J (B6) nucleus but two naturally occurring lineages, B6 NZB , where mitochondria generate more oxidative phosphorylation (OXPHOS)-derived reactive oxygen species (mROS). In a cardiac transplant model, Foxp3+ T regulatory (Treg) cells supported long-term allograft survival,...
Introduction: Bone loss and cognitive impairment are common in women living with HIV (WLWH) exacerbated by menopause. Bone-derived undercarboxylated osteocalcin (ucOCN) sclerostin appear to influence cognition. The current study investigated whether the circulating levels of these 2 proteins associated cognition midlife WLWH demographically similar seronegative women. Methods: Plasma samples from enrolled a musculoskeletal substudy within Women's Interagency Study were used measure ucOCN...
Combination antiretroviral therapy (cART) dramatically changed the face of HIV/AIDS pandemic, making it one most prominent medical breakthroughs past 3 decades. However, as life span persons living with HIV (PLWH) continues to approach that general population, same cannot be said regarding their quality life.
Lethal COVID-19 outcomes are attributed to classic cytokine storm. We revisit this using RNA sequencing of nasopharyngeal and 40 autopsy samples from patients dying SARS-CoV-2. Subsets the 100 top-upregulated genes in nasal swabs upregulated heart, lung, kidney, liver, but not mediastinal lymph nodes. Twenty-two these “noncanonical” immune genes, which we link components renin-angiotensin-activation-system that manifest as increased fibrin deposition, leaky vessels, thrombotic tendency,...
Abstract Lethal COVID-19 outcomes are most often attributed to classic cytokine storm and attendant excessive immune signaling. We re-visit this question using RNA sequencing in nasopharyngeal 40 autopsy samples from COVID-19-positive negative individuals. In nasal swabs, the top 100 genes which significantly correlated with viral load, include many canonical innate genes. However, 22 much less studied "non-canonical" found despite absence of transcripts, subsets these upregulated heart,...
Bone mineral density (BMD) loss in people living with HIV occurs the initiation of combined antiretroviral therapy (cART), particularly tenofovir disoproxil fumarate (TDF) containing cART. Switching from TDF to abacavir (ABC) or dolutegravir (DTG) leads increased BMD. Whether BMD gains are due cessation anabolic effects ABC DTG is unclear. We investigated and on osteoblast lineage cells
HIV anti-retrovirals (ARVs) have vastly improved the life expectancy of people living with (PLWH). However, toxic effects attributed to long-term ARV use also contribute HIV-related co-morbidities such as heart disease, bone loss and HIV-associated neurocognitive disorders (HAND). Unfortunately, mouse models used study ARVs on viral suppression, toxicity latency/tissue reservoirs not been widely established. Here, we demonstrate an effective model utilizing immune-compromised mice,...
Abstract The genomic architecture of 22q11.2 Deletion Syndrome (22q11.2DS) has focused on analysis white genomes. However, Black individuals appear to have a lower prevalence 22q11.2DS compared whites. To improve the understanding different populations in relation 22q11.2DS, optical mapping data from 106 genomes across various and were used determine organization structures. This revealed extensive variability between groups regarding copy number orientation changes elements comprising low...
Bone mineral density loss and fat accumulation are common in people living with HIV. The bone-derived hormone, undercarboxylated osteocalcin (ucOCN) regulates metabolism. We investigated the relationship between ucOCN change body among perimenopausal/postmenopausal HIV-seronegative HIV-seropositive women on long-term antiretrovirals.Perimenopausal postmenopausal enrolled Women's Interagency HIV Study MSK substudy underwent trunk total assessment by dual energy x-ray absorptiometry (DXA) at...