A5025101270- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Hematological disorders and diagnostics
- Diet and metabolism studies
- Lipid metabolism and disorders
- Cancer Genomics and Diagnostics
- Hematopoietic Stem Cell Transplantation
- Cancer-related molecular mechanisms research
- Pregnancy and preeclampsia studies
- Diet, Metabolism, and Disease
- Bone and Joint Diseases
- Parvovirus B19 Infection Studies
- Epigenetics and DNA Methylation
- Gut microbiota and health
- Blood Coagulation and Thrombosis Mechanisms
Shaanxi University of Science and Technology
2023
Genome and Company (South Korea)
2020-2023
Acquired somatic mutations in hematopoietic stem and progenitor cells (clonal hematopoiesis or CH) are associated with advanced age, increased risk of cardiovascular malignant diseases, decreased overall survival. These adverse sequelae may be mediated by altered inflammatory profiles observed patients CH. A pro-inflammatory immunologic profile is also worse outcomes certain infections, including SARS-CoV-2 its disease Covid-19. Whether CH predisposes to severe Covid-19 other infections...
Abstract Background and Aims Both clonal haematopoiesis of indeterminate potential (CHIP) atrial fibrillation (AF) are age-related conditions. This study investigated the role CHIP in development progression AF. Methods Deep-targeted sequencing 24 mutations (a mean depth coverage = 1000×) was performed 1004 patients with AF 3341 non-AF healthy subjects. Variant allele fraction ≥ 2.0% indicated presence mutations. The association between evaluated by comparison (i) prevalence subjects (ii)...
Abstract Aims Clonal haematopoiesis of indeterminate potential (CHIP), defined as a clonal expansion age-related recurrent somatic mutations, has recently emerged novel cardiovascular risk factor. However, the precise role CHIP in development atherosclerotic disease (ASCVD) remains unclear. Methods and results Among 4300 asymptomatic Korean participants aged 40–79 years, we investigated ASCVD by interplay between conventional factors development. Additionally, assessed changes coronary...
Introduction Clonal hematopoiesis of indeterminate potential (CHIP) is associated with atherosclerosis and cardiovascular disease. It has been suggested that CHIP may be related to diabetes, so we investigated the association between new-onset type 2 diabetes. Methods This study included 4,047 subjects aged >=40 years without To detect CHIP, targeted gene sequencing genomic DNA from peripheral blood cells was performed. The incidence diabetes during follow-up period evaluated. Results...
ABSTRACT Acquired somatic mutations in hematopoietic stem and progenitor cells (clonal hematopoiesis or CH) are associated with advanced age, increased risk of cardiovascular malignant diseases, decreased overall survival. 1–4 These adverse sequelae may be mediated by altered inflammatory profiles observed patients CH. 2,5,6 A pro-inflammatory immunologic profile is also worse outcomes certain infections, including SARS-CoV-2 its disease Covid-19. 7,8 Whether CH predisposes to severe...
Abstract Background Clonal hematopoiesis of indeterminate potential (CHIP) increases the risk cerebrovascular events, while its association with cerebral white matter hyperintensity (WMH) is undemonstrated. We evaluated effect CHIP and major driving mutations on WMH severity. Methods From an institutional cohort a routine health check‐up program DNA repository database, subjects who were ≥50 years age, one or more cardiovascular factors but no central nervous system disorder, performed brain...
Clonal hematopoiesis of indeterminate potential (CHIP) has been reported to be associated with increased cardiovascular disease, aging and insulin resistance. Despite the debate causal contribution CHIP on metabolic diseases, we want explore whether is related diabetic peripheral neuropathy (DPN).This study analyzed prevalence in patients type 2 diabetes classified according DPN status. Logistic regression analysis was used evaluate association between DPN.CHIP more prevalent subjects...
Food-derived polyphenols and their effects on type 2 diabetes are linked to the microbiota. Here, we expound mechanisms of food-derived that affect onset diabetes, focusing roles played by gut microorganisms metabolites they produce. We also discuss mechanism lower blood glucose through host signaling-mediated inflammatory responses. alleviate development remodeling microbiome composition reducing inhibit activity <i>α</i>-glucosidase, <i>α</i>-amylase, dipeptidyl peptidase IV enzymes reduce...
ABSTRACT Background Clonal hematopoiesis of indeterminate potential (CHIP), defined as a clonal expansion hematopoietic stem cells with age-related recurrent somatic mutations, has recently emerged novel cardiovascular risk factor. However, the pathogenic mechanism CHIP in atherosclerotic disease (ASCVD) development is not yet fully understood. Methods In cohort comprising 4,300 asymptomatic Korean participants aged 40–79 years, we investigated risks associated ASCVD by and interplay other...