A5101447227- RNA Research and Splicing
- Acute Myeloid Leukemia Research
- Mesenchymal stem cell research
- RNA modifications and cancer
- Tissue Engineering and Regenerative Medicine
- Cancer-related gene regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Trypanosoma species research and implications
- TGF-β signaling in diseases
- Neonatal Health and Biochemistry
- Platelet Disorders and Treatments
- Trace Elements in Health
- Pluripotent Stem Cells Research
- Cancer-related molecular mechanisms research
- Congenital Anomalies and Fetal Surgery
- Renal and related cancers
- Sperm and Testicular Function
- RNA and protein synthesis mechanisms
- Hemoglobin structure and function
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hearing, Cochlea, Tinnitus, Genetics
- Gastrointestinal Tumor Research and Treatment
- Axon Guidance and Neuronal Signaling
- Vestibular and auditory disorders
- Diabetes Treatment and Management
Southern Illinois University School of Medicine
2022-2024
National Research Centre on Equines
2013-2021
Deciphera Pharmaceuticals (United States)
2017-2021
National Dairy Research Institute
2017
Cleveland Clinic
2014-2016
Cleveland Clinic Lerner College of Medicine
2009-2015
University of Alabama
1985-2015
Indian Council of Medical Research
2014
Mahavir Cancer Institute and Research Centre
2014
Chaudhary Devi Lal University
2013
Minor RNA splicing defects can cause a major human developmental disorder.
Mammary epithelial cells constitutively expressing Id-1 protein are unable to differentiate, acquire the ability proliferate, and invade extracellular matrix. In addition, is aberrantly over-expressed in aggressive metastatic breast cancer cells, as well human tumor biopsies from infiltrating carcinomas, suggesting might be an important regulator of progression. We show that become significantly less invasive vitro vivo when down-regulated by stable transduction with antisense Id-1....
Abstract EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression. However, evidence also exists possess antitumorigenic properties, raising a critical question on the role of tumorigenesis vivo. We report here deletion mouse led to markedly enhanced susceptibility 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate (DMBA/TPA) two-stage skin carcinogenesis. EphA2-null mice developed...
Abstract Alterations in the basement membrane receptor dystroglycan (DG) are evident muscular dystrophies and carcinoma cells characterized by a selective loss or modification of extracellular α-DG subunit. Defects posttranslational modifications DG have been identified some dystrophies, but underlying not yet defined. We reveal here multiple that modulate composition function normal epithelial cells. show is shed from cell surface tumorigenic through proteolytic mechanism does require...
Introduction Hair cells (HCs) of the cochlea are responsible for sound transduction and hearing perception in mammals. Genetic mutations transcription factor Pou4f3 cause non-syndromic autosomal dominant loss humans (DFNA15) which varies age onset depending on individual mutation. Mouse models with germline deletion or have previously demonstrated its critical role maturation survival cochlear HCs during embryonic development. However, auditory function maintenance after birth adulthood has...
Background: Androgens, encompassing testosterone, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA) and androstenedione, serve as pivotal regulators of semen quality in bulls. Despite their recognized efficacy enhancing sexual performance fertility humans, herbal feed supplements remain relatively unexplored the realm animal husbandry. Moreover, prevailing issue suboptimal among crossbred bulls poses a significant challenge to cattle industry. This study aimed impact supplementation...
This research proposes a novel security solution for IoT networks by integrating Practical Byzantine Fault Tolerance (PBFT) with Elliptic Curve Cryptography (ECC). The approach aims to enhance authentication, ensure data integrity, and optimize resource use in resource-constrained environments. By combining ECC's lightweight cryptographic capabilities PBFT's consensus model, the system achieves high performance, scalability, robust fault tolerance, providing secure framework communication....
Mammary epithelial cells proliferate, invade the stroma, differentiate, and die in adult mammals by mechanisms that are poorly understood. We found Id-1, an inhibitor of basic helix-loop-helix transcription factors, regulates mammary cell growth, differentiation, invasion culture. Here, we show Id-1 is expressed highly during development virgin mice early pregnancy, when proliferation high. During mid-pregnancy, expression declined to undetectable levels as epithelium differentiated fully....
The heterogeneous nuclear ribonucleoproteins (hnRNP) form a large family of RNA-binding proteins that exert numerous functions in RNA metabolism. RALY is member the hnRNP binds poly-U–rich elements within several RNAs and regulates expression specific transcripts. up-regulated different types cancer, its down-regulation impairs cell cycle progression. However, RALY’s role regulating levels remains elusive. Here, we show genes coding for factors involved transcription regulation exhibit an...
Abstract Carbon monoxide (CO) is said to be the most widely encountered occupational and environmental contaminant. Threshold for CO‐induced fetotoxicity was studied using mouse as an experimental animal. Pregnant animals of CD‐1 strain were exposed 0, 65, 125, 250, or 500 ppm CO from gestation day 7 18. The sacrificed on 18, their uterine horns examined live resorbed fetuses. data suggest that maternal exposure low 125 affects fetal growth higher levels affect viability. also developing...
The majority of gastrointestinal stromal tumors (GIST) harbor constitutively activating mutations in KIT tyrosine kinase. Imatinib, sunitinib, and regorafenib are available as first-, second-, third-line targeted therapies, respectively, for metastatic or unresectable KIT-driven GIST. Treatment patients with GIST kinase inhibitors generally leads to a partial response stable disease but most eventually progress by developing secondary resistance KIT. Tumor heterogeneity resistant within the...
Abstract Experiments were carried out to determine the teratogenicity and developmental toxicity of carbon monoxide (CO) in mice fed protein‐deficient diets. Pregnant CD‐1 27 (control), 16, 8, or 4% protein diets throughout gestation each group was exposed 0 65, 125, 250, 500 ppm CO from days 8–18. The exposure continuous except for daily watering, feeding cage changing. animals killed on day 18. Pregnancy status dams examined. Fetuses examined gross skeletal malformations. percentages dead...
Id proteins are dominant negative regulators of basic helix-loop-helix transcription factors. Previous work in our laboratory has shown that constitutive expression Id-1 SCp2 mouse mammary epithelial cells inhibits their differentiation and induces proliferation, invasion, migration. also correlates with the invasive aggressive potential human breast cancer cells. However, little is known about target genes important for regulating normal transformed cell phenotypes. Now we report cloning a...
Abstract A mouse model with cisplatin-induced ototoxicity was used in addition to human samples from the ITMAT Biobank at University of Pennsylvania. Mouse auditory brainstem responses (ABR), inner ear histology, perilymph cisplatin sampling, and measurement serum prestin via ELISA were performed. Human level measured patients otological issues after treatment compared matched controls. Serum significantly elevated before ABR threshold shifts mice exposed control mice. Prestin concentration...