A5061895399- Obsessive-Compulsive Spectrum Disorders
- Neurological disorders and treatments
- Theology and Canon Law Studies
- Religion, Theology, and Education
- Behavioral and Psychological Studies
- Transcranial Magnetic Stimulation Studies
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Reformation and Early Modern Christianity
- Autism Spectrum Disorder Research
- Law and Political Science
- Political and Social Issues
- Religion, Theology, History, Judaism, Christianity
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Historical and Religious Studies of Rome
- Botulinum Toxin and Related Neurological Disorders
- Neurotransmitter Receptor Influence on Behavior
- Body Image and Dysmorphia Studies
- Neuroscience and Music Perception
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Religious Freedom and Discrimination
- Neurology and Historical Studies
- Gaze Tracking and Assistive Technology
- Spine and Intervertebral Disc Pathology
University Hospital Cologne
2015-2024
University of Cologne
2015-2024
European Graduate School of Neuroscience
2023
OsloMet – Oslo Metropolitan University
2023
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2014-2020
BackgroundDeep brain stimulation (DBS) of the thalamus can effectively reduce tics in severely affected patients with Tourette syndrome (TS). Its effect on cortical oscillatory activity is currently unknown.ObjectiveWe assessed whether DBS modulates beta at fronto-central electrodes. We explored concurrent EEG sources and probabilistic maps.MethodsResting state TS treated thalamic was recorded repeated DBS-on DBS-off states. A mixed linear model employed for statistical evaluation. were...
There is still a lack of controlled studies to prove efficacy thalamic deep brain stimulation for Tourette's Syndrome.In this trial, we investigated the course tic severity, comorbidities and quality life during whether changes in severity can be assigned ongoing compared sham stimulation.We included eight adult patients with medically refractory syndrome. Bilateral electrodes were implanted centromedian-parafascicular-complex nucleus ventro-oralis internus. Tic assessed before surgery as...
Abstract Gilles de la Tourette Syndrome (GTS) is a chronic tic disorder, characterized by unwanted motor actions and vocalizations. While brain stimulation techniques show promise in reducing severity, optimal target networks are not well-defined. Here, we leverage datasets from two independent deep (DBS) cohorts cohort of tic-inducing lesions to infer critical for treatment occurrence tics mapping sites functional connectome derived 1,000 healthy participants. We find that greater reduction...
In this paper we do the following: First describe remit and programme of University London’s Wider Benefits Learning Research Centre, which studies noneconomic effects learning, at individual but also collective level. We set out a theoretical framework for our programme, organised around three ‘capitals’: human capital, social identity capital. After that report results drawn from two large-scale longitudinal datasets. use data collected in 1958 cohort study ages 33 42 to assess wider...
Closed-loop neuromodulation is presumed to be the logical evolution for improving effectiveness of deep brain stimulation (DBS) treatment protocols (Widge et al., 2018). Identifying symptom-relevant biomarkers that provide meaningful feedback stimulator devices an important initial step in this direction. This report demonstrates a technique assaying neural circuitry hypothesized contribute OCD and DBS outcomes. We computed phase-lag connectivity between LFPs EEGs thirteen...
Deep brain stimulation (DBS) of the nucleus accumbens (NAc) shows first promising results in patients with severe substance use disorder (SUD), a patient group known to have deficits self-control. One facet self-control is ability forego smaller sooner rewards favor larger later (delay discounting, DD). The NAc has been suggested integrate motivational information guide behavior while consequences NAc-DBS on DD are unknown. To this end, nine SUD performed task DBS and after 24 h off period....
Abstract The occurrence of tics in Tourette syndrome (TS) has often been linked to impaired cognitive control, but empirical findings are still inconclusive. A recent view proposes that may be the result an abnormally strong interrelation between perceptual processes and motor actions, commonly referred as perception-action binding. general aim present study was examine proactive control binding effects context task switching adult human patients with TS matched healthy controls. cued...
Obsessive-compulsive disorder (OCD) is a psychiatric with alterations of cortico-striato-thalamo-cortical loops and impaired performance monitoring. Electrophysiological markers such as conflict-related medial frontal theta (MFT) error-related negativity (ERN) may be altered by clinically effective deep brain stimulation (DBS) the anterior limb internal capsule nucleus accumbens (ALIC/NAc). We hypothesized that ALIC/NAc DBS modulates electrophysiological monitoring markers.Fifteen patients...
Deep brain stimulation of the anterior limb internal capsule (ALIC)/nucleus accumbens is an effective treatment in patients with obsessive-compulsive disorder but may increase impulsive behavior. We aimed to investigate how active alters subdomains decision making and whether respective effects depend on location sites. assessed 15 participants performing Cambridge Gambling Task during inactive ALIC/nucleus deep stimulation. Specifically, we determined stimulation-induced changes risk...
Since 1999, several targets for deep brain stimulation (DBS) in Gilles de la Tourette syndrome (GTS) have emerged showing similar success rates. Studies using different tractography techniques identified connectivity profiles associated with a better outcome individual targets. However, GTS patients might need individualized therapy. The objective of this study is to analyze the profile DBS GTS. We standard target coordinates centromedian nucleus/nucleus ventro-oralis internus (CM/Voi),...
Tourette syndrome is a neurodevelopmental disorder associated with hyperactivity in dopaminergic networks. Dopaminergic the basal ganglia has previously been linked to increased sensitivity positive reinforcement and increases choice impulsivity. In this study, we examine whether extends changes temporal discounting, where impulsivity operationalized as an preference for smaller-but-sooner over larger-but-later rewards. We assessed intertemporal two studies including nineteen adolescents...
Symptoms of obsessive–compulsive disorder (OCD) are partly related to impaired cognitive control processes and theta modulations constitute an important electrophysiological marker for such as signaling negative performance feedback in a fronto-striatal network. Deep brain stimulation (DBS) targeting the anterior limb internal capsule (ALIC)/nucleus accumbens (NAc) shows clinical efficacy OCD, while exact influence on monitoring system remains largely unknown. Seventeen patients with...
When choosing between rewards that differ in temporal proximity (intertemporal choice), human preferences are typically stable, constituting a clinically relevant transdiagnostic trait. Here we show, female and male patients undergoing deep brain stimulation (DBS) of the anterior limb internal capsule/NAcc region for treatment-resistant obsessive-compulsive disorder, long-term chronic (but not phasic) DBS disrupts intertemporal preferences. Hierarchical Bayesian modeling accounting...
For successful goal-directed behavior, a performance monitoring system is essential. It detects behavioral errors and initiates adaptations to improve performance. Two electrophysiological potentials are known follow in reaction time tasks: the error-related negativity (ERN), which linked error processing, positivity (Pe), associated with subjective awareness. Furthermore, correct-related (CRN) uncertainty about response outcome. Here we attempted identify involvement of nucleus accumbens...
Gilles de la Tourette Syndrome (GTS) is the most severe form of chronic tic disorders, characterized by uncontrollable motor actions and vocalizations. While brain stimulation techniques show promise in reducing severity, optimal target networks are not well-defined. Here, we leveraged datasets from two independent deep (DBS) cohorts a cohort tic-inducing lesions to infer critical for treatment occurrence tics mapping sites functional connectome derived 1,000 healthy participants. We found...
Abstract Thalamic deep brain stimulation (DBS) has shown clinical improvement for patients with treatment-refractory Tourette Syndrome (TS). Advancing DBS TS requires identifying reliable electrophysiological markers. Recognising as a network disorder, we investigated thalamo-cortical oscillatory connectivity by combining local field potential (LFP) recordings from the thalamic target region using Percept TM PC neurostimulator high-density EEG in eight male (aged 27 to 38) while was off. We...