A5056724594- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Vagus Nerve Stimulation Research
- Advanced MRI Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Advanced Neuroimaging Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Cerebrospinal fluid and hydrocephalus
- Obsessive-Compulsive Spectrum Disorders
- Ultrasound Imaging and Elastography
- Attention Deficit Hyperactivity Disorder
- Fetal and Pediatric Neurological Disorders
- Pharmacological Effects and Toxicity Studies
- Neonatal and fetal brain pathology
- Neuroscience and Neural Engineering
- Cardiac pacing and defibrillation studies
- Autism Spectrum Disorder Research
- Assistive Technology in Communication and Mobility
- Surgical Simulation and Training
- Neuroscience of respiration and sleep
- Pain Management and Treatment
University of Toronto
2018-2025
Hospital for Sick Children
2020-2025
SickKids Foundation
2020-2025
Ontario Brain Institute
2025
Centre Hospitalier Universitaire Sainte-Justine
2024
Brown University
2024
University of California, Los Angeles
2024
Université de Montréal
2024
Great Ormond Street Hospital
2022
University College London
2022
Objective Vagus nerve stimulation (VNS) is a common treatment for medically intractable epilepsy, but response rates are highly variable, with no preoperative means of identifying good candidates. This study aimed to predict VNS using structural and functional connectomic profiling. Methods Fifty‐six children, comprising discovery (n = 38) validation 18) cohorts, were recruited from 3 separate institutions. Diffusion tensor imaging was used identify group differences in white matter...
Outcomes following vagus nerve stimulation (VNS) improve over years after implantation in children with drug‐resistant epilepsy. The added value of deep brain (DBS) instead continued VNS optimization is unknown. In a prospective, non‐blinded, randomized patient preference trial 18 (aged 8–17 years) who did not respond to at least 1 year, add‐on DBS resulted greater seizure reduction compared an additional year (51.9% vs. 12.3%, p = 0.047). Add‐on also less bothersome seizures ( 0.03), but no...
Deep brain stimulation of the centromedian nucleus thalamus (CM-DBS) is an investigational, off-label treatment for drug-resistant epilepsy (DRE) in children. Although emerging evidence supports its safety and efficacy select indications, effect CM-DBS on quality life functional outcomes such as school attendance has not been studied. Here, we analyzed data from prospective CHILD-DBS (Child & Youth Comprehensive Longitudinal Database Brain Stimulation) to examine impact patient-...
Abstract Treatment-resistant epilepsy is a common and debilitating neurological condition, for which neurosurgical cure possible. Despite undergoing nearly identical ablation procedures however, individuals with treatment-resistant frequently exhibit heterogeneous outcomes. We hypothesized that treatment response may be related to the brain regions MR-guided laser volumes are functionally connected. To test this, we mapped resting-state functional connectivity of surgical ablations either...
There is an unmet need to develop robust predictive algorithms preoperatively identify pediatric epilepsy patients who will respond vagus nerve stimulation (VNS). Given the similarity in neural circuitry between and median afferent projections primary somatosensory cortex, current study hypothesized that evoked field(s) (SEFs) could be used predict seizure response VNS. Retrospective data from forty-eight underwent VNS at two different institutions were this study. Thirty-six (“Discovery...
Gelastic seizures due to hypothalamic hamartomas (HH) are challenging treat, in part an incomplete understanding of seizure propagation pathways. Although magnetic resonance imaging-guided laser interstitial thermal therapy (MRgLITT) is a promising intervention disconnect HH from ictal networks, the optimal site ablation achieve freedom not known. In this study, we investigated intraoperative post-ablation changes resting-state functional connectivity identify large-scale networks associated...
OBJECTIVE Functional hemispherectomy is an effective surgical intervention for select patients with drug-resistant epilepsy. The last several decades have seen dramatic evolutions in preoperative evaluation, techniques, and postoperative care. Here, the authors present a retrospective review of medical records 146 children who underwent between 1987 2022 at Hospital Sick Children, providing unique overview evolution procedure patient outcomes over 35 years. METHODS all Children were...
Abstract Lesion network mapping (LNM) has been applied to true lesions (e.g., cerebrovascular in stroke) identify functionally connected brain networks. No previous studies have utilized LNM for analysis of intra-axial mass lesions. Here, we implemented identification potentially vulnerable epileptogenic networks causing medically-refractory epilepsy (MRE). Intra-axial were manually segmented patients with MRE seen at our institution (EL_INST). These then normalized standard space and used...
OBJECTIVE The development of transcranial MR-guided focused ultrasound (MRgFUS) has revitalized the practice lesioning procedures in functional neurosurgery. Previous health economic analysis found MRgFUS thalamotomy to be a cost-effective treatment for patients with essential tremor, supporting its reimbursement. With publication level I evidence support tremor-dominant Parkinson’s disease (TDPD), authors performed comparison between MRgFUS, deep brain stimulation (DBS), and medical...
OBJECTIVE Magnetic resonance imaging–guided focused ultrasound (MRgFUS) is an emerging treatment modality that enables incisionless ablative neurosurgical procedures. Bilateral MRgFUS capsulotomy has recently been demonstrated to be safe and effective in treating obsessive-compulsive disorder (OCD) major depressive (MDD). Preliminary evidence suggested bilateral can present increased difficulties reaching lesional temperatures as compared unilateral thalamotomy. The authors of this article...