A5010807952- Ultrasound and Hyperthermia Applications
- Ultrasound Imaging and Elastography
- Photoacoustic and Ultrasonic Imaging
- Advanced MRI Techniques and Applications
- Ultrasound and Cavitation Phenomena
- Fetal and Pediatric Neurological Disorders
- Cerebral Venous Sinus Thrombosis
- Neurological disorders and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Ultrasound in Clinical Applications
- Trigeminal Neuralgia and Treatments
- Medical Image Segmentation Techniques
- Infrared Thermography in Medicine
- Traumatic Brain Injury and Neurovascular Disturbances
- Meningioma and schwannoma management
- Epilepsy research and treatment
- Radiomics and Machine Learning in Medical Imaging
- SARS-CoV-2 and COVID-19 Research
- AI in cancer detection
- Flow Measurement and Analysis
- Surgical Simulation and Training
- Glioma Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Thyroid and Parathyroid Surgery
- Metabolism and Genetic Disorders
University School
2024
Case Western Reserve University
2024
Focused Ultrasound Foundation
2013-2022
University of Virginia
1992-2022
Neurological Surgery
2022
HemoSonics (United States)
2011
University of Illinois Chicago
1971
MR imaging-guided focused sonography surgery is a new stereotactic technique that uses high-intensity to heat and ablate tissue. The goal of this study was describe imaging findings pre- post-ventralis intermedius nucleus lesioning by as treatment for essential tremor determine whether there an association between these features the clinical response sonography.Fifteen patients with medication-refractory prospectively gave consent; were enrolled in single-site, FDA-approved pilot trial;...
Histotripsy is an ultrasound-based treatment modality relying on the generation of targeted cavitation bubble clouds, which mechanically fractionate tissue. The purpose current study was to investigate in vivo feasibility, including dosage requirements and safety, generating well-confined destructive lesions within porcine brain utilizing histotripsy technology.
Transcranial magnetic resonance-guided focused ultrasound (TcMRgFUS) brain treatment systems compensate for skull-induced beam aberrations by adjusting the phase and amplitude of individual transducer elements. These corrections are currently calculated based on a preacquired computed tomography (CT) scan patient's head. The purpose work presented here is to demonstrate feasibility using ultrashort echo-time resonance imaging (UTE MRI) instead CT calculate apply aberration clinical TcMRgFUS...
Intracerebral hemorrhage (ICH) is a major cause of death and disability throughout the world. Surgical techniques are limited by their invasive nature associated caused during clot removal. Preliminary data have shown promise for feasibility transcranial MR-guided focused ultrasound (MRgFUS) sonothrombolysis in liquefying clotted blood ICH thereby facilitating minimally evacuation via twist-drill craniostomy aspiration tube.In an vitro model, following optimum parameters were determined:...
OBJECTIVE In appropriate candidates, the treatment of medication-refractory mesial temporal lobe epilepsy (MTLE) is primarily surgical. Traditional anterior lobectomy yields seizure-free rates 60%-70% and possibly higher. The field magnetic resonance-guided focused ultrasound (MRgFUS) an evolving in neurosurgery. There potential to treat MTLE with MRgFUS; however, it has appeared that structures were beyond existing envelope currently available clinical systems. purpose this study was...
Abstract Transcranial focused ultrasound with the InSightec Exablate system uses thermal ablation for treatment of movement and mood disorders blood brain barrier disruption tumor therapy. The computed tomography (CT) images to calculate phase corrections that account aberrations caused by human skull. This work investigates whether magnetic resonance (MR) can be used as an alternative CT corrections. Phase were calculated using gold standard hydrophone method care ray tracing method. MR...
Transcranial MR-guided focused ultrasound surgery (MRgFUS) is evolving as a treatment modality in neurosurgery. Until now, the trigeminal nerve was believed to be beyond envelope of existing high-frequency transcranial MRgFUS systems. In this study, authors explore feasibility targeting cadaveric model with temperature assessments using computer simulations and an vitro skull phantom fitted thermocouples.Six nerves from 4 unpreserved cadavers were targeted first experiment. Preprocedural CT...
Abstract The InSightec Exablate system is the standard of care used for transcranial focused ultrasound ablation treatments in United States. calculates phase corrections that account aberrations caused by human skull. This work investigates whether skull aberration correction can be improved comparing ray tracing method with hybrid angular spectrum (HAS) and gold hydrophone method. Three degassed ex vivo skulls were sonicated a 670 kHz hemispherical phased array transducer (InSightec 4000)....
Abstract Objective : Phase aberration correction is essential in transcranial histotripsy to compensate for focal distortion caused by the heterogeneity of intact skull bone. This paper improves 2-step (AC) method that has been previously presented and develops an AC workflow fits clinical environment, which computed tomography (CT)-based analytical approach was first implemented, followed a cavitation-based using shockwaves from acoustic cavitation emission (ACE). Approach: A 700 kHz,...
In transcranial focused ultrasound therapies, such as treating essential tremor via thermal ablation in the thalamus, acoustic energy is through skull using a phased-array transducer. Ray tracing computationally efficient method that can correct skull-induced phase aberrations per-element delay calculations patient-specific computed tomography (CT) data. However, recent studies show variations CT-derived Hounsfield unit may account for only 50% of speed sound variability human specimens,...
Image-guided focused ultrasound (FUS) is a noninvasive therapeutic technology platform that results from the marriage of FUS therapy and MR or imaging. The thermal mechanical mechanisms interaction with targeted tissue can produce variety localized biological effects enable treatment wide range clinical conditions, uterine fibroids to prostate liver cancer, neurological disorders. Coupling either imaging enables precise targeting, planning, monitoring confirmation in real time. Future...
OBJECT In biological tissues, it is known that the creation of gas bubbles (cavitation) during ultrasound exposure more likely to occur at lower rather than higher frequencies. Upon collapsing, such can induce hemorrhage. Thus, acoustic inertial cavitation secondary a 220-kHz MRI-guided focused (MRgFUS) surgery serious safety issue, and animal studies are mandatory for laying groundwork use low-frequency systems in future clinical trials. The authors investigate here vivo potential...
Transcranial focused ultrasound (FUS) ablation is an emerging incision-less treatment for neurological disorders. The factors affecting FUS efficiency are not well understood. Kranion open-source software that allows the user to simulate planning stages of and "replay" previous treatments off-line analysis. This study aimed investigate relationship between skull parameters create a metric estimate temperature rise during FUS. CT images from 28 patients were analyzed validate use Kranion. For...
Precise focusing is essential for transcranial MRI-guided focused ultrasound (TcMRgFUS) to minimize collateral damage non-diseased tissues and achieve temperatures capable of inducing coagulative necrosis at acceptable power deposition levels. CT usually used this refocusing but requires a separate study (CT) ahead the TcMRgFUS procedure. The goal was determine whether MRI using an appropriate sequence would be viable alternative planning in TcMRgFUS. We tested three pulse sequences (3D T1...
A new medical image analysis system to quantify atherosclerosis in the lower abdominal aorta using magnetic resonance imaging is described. This and display permits quantification of three-dimensional (3D) properties vessel wall lumen cross-sectional area volumes. Preliminary results employing this capability on images demonstrated a twofold increase volume per unit length, corresponding intimal thickening, before luminal narrowing was detected. work feasibility usefulness quantitatively...
Abstract Background The phase correction on transcranial focused ultrasound is essential to regulate unwanted focal point shift caused by skull bone aberration. aim of the current study was design and investigate feasibility a ray-based toolkit for ultrasound. Results peak pressure at area improved 140.5 ± 7.0% target I 134.8 19.1% II using proposed toolkit, respectively. A total computation time 402.1 24.5 milliseconds achieved each sonication. Conclusion designed software can be used as...
OBJECTIVE Magnetic resonance imaging–guided focused ultrasound (MRgFUS) is an emerging treatment modality that enables incisionless ablative neurosurgical procedures. Bilateral MRgFUS capsulotomy has recently been demonstrated to be safe and effective in treating obsessive-compulsive disorder (OCD) major depressive (MDD). Preliminary evidence suggested bilateral can present increased difficulties reaching lesional temperatures as compared unilateral thalamotomy. The authors of this article...
Pairwise compatibility between virus and host proteins can dictate the outcome of infection. During transmission, both inter- intraspecies variabilities in receptor protein sequences impact cell susceptibility. Many viruses possess mutable viral entry patterns shift as sequence changes. This combinatorial space is poorly understood, traditional experimental approaches lack throughput to simultaneously test all possible combinations sequences. Here, we created a pseudotyped infection assay...
During focused ultrasound ablation (FUSA), the presumed stereotactic target is tested with subthreshold sonications before permanent ablation. This testing relies on ultrasound-induced reversible clinical effects (thermal neuromodulation, TN). However, thermal dose and spot size thresholds to induce TN are not yet defined.To define associated TN.We performed a retrospective analysis of intraoperative FUSA data essential tremor patients. Sonications less than 25 cumulative equivalent minutes...
BackgroundVolatile anaesthetics are widely used in human medicine. Although generally safe, hypersensitivity and toxicity can occur rare cases, such as certain genetic disorders. Anaesthesia is well-documented a subset of mitochondrial diseases, but whether volatile toxic this setting has not been explored.MethodsWe exposed Ndufs4(−/−) mice, model Leigh syndrome, to isoflurane (0.2–0.6%), oxygen 100%, or air. Cardiorespiratory function, weight, blood metabolites, survival were assessed. We...