A5053398745- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Cavitation Phenomena
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Shape Memory Alloy Transformations
- Ultrasound Imaging and Elastography
- Crystallography and molecular interactions
- Astro and Planetary Science
- Apelin-related biomedical research
- Crystal structures of chemical compounds
- Advanced Memory and Neural Computing
- Advanced MRI Techniques and Applications
- Financial Markets and Investment Strategies
- Dielectric materials and actuators
- Ocular Surface and Contact Lens
- Nanoparticle-Based Drug Delivery
- Quantum Dots Synthesis And Properties
- Perovskite Materials and Applications
- Corporate Finance and Governance
- Polymer composites and self-healing
- Planetary Science and Exploration
- Hybrid Renewable Energy Systems
- Proteoglycans and glycosaminoglycans research
- Hydrogen Storage and Materials
CSIRO Manufacturing
2020-2024
MaRS
2023
Columbia University
2008-2017
Quantum (Australia)
2014
SUNY Polytechnic Institute
2011
New York University
2011
University of Auckland
2006
XinHua Hospital
2002
Cavitation events seeded by microbubbles have been previously reported to be associated with MR- or fluorescent-contrast enhancement after focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening. However, it is still unknown whether bubble activity can correlated the reversibility (the duration of opening and likelihood safe reinstatement) permeability opened BBB, which critical for clinical translation using passive cavitation detection monitor, predict control In this study,...
The delivery of drugs to specific neural targets faces two fundamental problems: (1) most do not cross the blood-brain barrier, and (2) those that do, spread entire brain. To date, there exists only one non-invasive methodology with potential solve these selective barrier (BBB) opening using micro-bubble enhanced focused ultrasound. We have recently developed a single-element 500-kHz spherical transducer ultrasound setup for targeted BBB in non-human primate does require simultaneous MRI...
Central nervous system (CNS) diseases are difficult to treat because of the blood-brain barrier (BBB), which prevents most drugs from entering into brain. Intranasal (IN) administration is a promising approach for drug delivery brain, bypassing BBB; however, its application has been restricted particularly potent substances and it does not offer localized specific brain sites. Focused ultrasound (FUS) in combination with microbubbles can deliver at targeted locations. The present study...
Focused ultrasound with nanodroplets could facilitate localized drug delivery after vaporization potentially improved in vivo stability, payload, and minimal interference outside of the focal zone compared microbubbles. While feasibility blood-brain barrier (BBB) opening using has been previously reported, characterization associated not achieved. It was hypothesized that outcome droplet's sensitivity to acoustic energy, can be modulated boiling point liquid core. Therefore, this study,...
Focused ultrasound in conjunction with lipid microbubbles has fully demonstrated its ability to induce non-invasive, transient, and reversible blood-brain barrier opening. This study was aimed at testing the feasibility of our lipid-coated as a vector for targeted drug delivery treatment central nervous system diseases. These were labeled fluorophore 5-dodecanoylaminfluorescein. mouse brains vivo presence these trans-blood-brain new approach, compared previously studies group, where...
The thin physical profile of perovskite-based solar cells (PSCs) fabricated on flexible substrates provides the prospect a disruptive increase in specific power (power-to-mass ratio), an important figure-of-merit for to be used space applications. In contrast recent reports applications PSCs which focus rigid glass-based devices, this work we investigate suitability low-earth orbit (LEO) applications, where perovskite layer was prepared using either Ruddlesden–Popper precursor composition...
Using microbubbles as model systems, we examined molecular diffusion and binding to colloidal surfaces in bimodal poly(ethylene glycol) (PEG) brush layers. A microbubble is a gaseous particle with diameter of less than 10 μm, which the surface comprises amphiphilic phospholipids self-assembled form lipid monolayer shell. Due compressible gas core, provide sensitive acoustic response are currently used ultrasound contrast agents. Similar design long circulating liposomes, PEG chains typically...
Metal alloys and intermetallic compounds offer an attractive method for safely storing hydrogen (H2). The metal absorb H2 into their structure, often swelling fracturing as a result of phase transformation during hydride formation/decomposition cycles. absorption is exothermic process, requiring the effective efficient removal heat. This can be challenging heat transfer to/from powdered beds notoriously difficult, limited by poor thermal conductivity. Hence, observed reaction kinetics...
To fully assess contrast-enhanced acoustic bioeffects in diagnostic and therapeutic procedures, the mechanical properties of microbubbles need to be considered. In present study, direct measurements microbubble stiffness were performed using atomic force microscopy by applying nanoscale compressions (up 25 nN/s) on size-isolated, lipidcoated (diameter ranges 4 6 μm 8 μm). The was found lie between 22 mN/m decrease exponentially with size within diameter range investigated. No cantilever...
In this article we aim to combine video data analysis techniques, scalable machine learning, and Shape memory polymers (SMPs) materials develop a model-based architecture for the advancement of rapid characterization novel material. Although artificially intelligent machines, e.g. soft robotics systems, with high flexibility have conquered production line other controlled, predictable environments, their use in complex real-world scenarios has date remained limited. Newly discovered...
Four novel organic salts of piperazine and 2-methylpiperazine with p-toluenesulfonic acid chloroacetic have been synthesized structurally characterized. The hydrogen-bonding ring synthons that exist between the cation/anion pairs are compared contrasted alongside database results.
Abstract Extraordinary shape recovery capabilities of memory alloys (SMAs) have made them a crucial building block for the development next-generation soft robotic systems and associated cognitive controllers. In this study we desired to determine whether combining video data analysis techniques with machine learning could develop computer vision based predictive system accurately predict force generated by movement SMA body that is capable multi-point actuation performance. We identified...
Lipid-shelled microbubbles have been used in ultrasound-mediated drug delivery. The physicochemical properties of the microbubble shell could affect delivery efficiency since they determine mechanical properties, circulation persistence, and dissolution behavior during cavitation. Therefore, aim this study was to investigate effects on brain via blood-brain barrier (BBB) opening vivo using monodisperse with different phospholipid components. monolayer were varied by phospholipids hydrophobic...
Microbubble (MB)-assisted focused ultrasound is a promising technique for delivering drugs to the brain by noninvasively and transiently opening blood-brain barrier (BBB), monitoring BBB using passive cavitation detection (PCD) critical in detecting its occurrence, extent as well assessing mechanism. One of main obstacles achieving those objectives large animals transcranial attenuation. To study effects, response through in-vitro non-human primate (NHP) skull was investigated. In-house...
In order to fully assess contrast-enhanced acoustic bioeffects in diagnostic and therapeutic applications, the mechanical properties of microbubbles need be taken into account. current study, direct measurements microbubble apparent stiffness were performed using atomic force microscopy by applying nanoscale compressions (up 25 nN/s) on size-isolated, phospholipid-coated (diameters between 4-6 6-8 μm). The was found lie 4 22 mN/m decrease exponentially with size within diameter range...
Focused ultrasound with nanodroplets could facilitate localized drug delivery after vaporization potentially improved in vivo stability, payload, and minimal interference outside of the focal zone compared microbubbles. While feasibility blood-brain barrier (BBB) opening using has been previously reported, characterization associated not achieved. It was hypothesized that outcome droplet sensitivity to acoustic energy, can be modulated boiling point liquid core. Therefore, this study,...
Focused ultrasound (FUS) with microbubbles (MB) is promising for assisting the delivery of drugs across blood-brain barrier (BBB). To assess safety and efficacy, monitoring using passive cavitation detection (PCD) critical yet reliability transcranial in large animals remained questioned. study primate skull effect, PCD through in-vitro monkey human skulls vivo monkeys during sonication (FUS frequency: 500 kHz) were investigated, use in-house made lipid-shelled, monodisperse MB (median...