A5002805546- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Cavitation Phenomena
- Ultrasound Imaging and Elastography
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced MRI Techniques and Applications
- Thermoregulation and physiological responses
- Microfluidic and Capillary Electrophoresis Applications
- Cardiovascular and Diving-Related Complications
- Microfluidic and Bio-sensing Technologies
- Fluid Dynamics and Mixing
- Lanthanide and Transition Metal Complexes
- Thermography and Photoacoustic Techniques
- Spectroscopy Techniques in Biomedical and Chemical Research
- Gas Dynamics and Kinetic Theory
- Flow Measurement and Analysis
- African Sexualities and LGBTQ+ Issues
- Optical properties and cooling technologies in crystalline materials
- Fluid Dynamics and Heat Transfer
- Synthesis and Characterization of Heterocyclic Compounds
- Adenosine and Purinergic Signaling
- Political Economy and Marxism
- Electrowetting and Microfluidic Technologies
- International Arbitration and Investment Law
- Global Financial Crisis and Policies
Philips (United States)
2019-2021
Philips (Finland)
2021
Sunnybrook Research Institute
2015-2020
University of Toronto
2015-2020
Sunnybrook Health Science Centre
2015-2020
Oregon Health & Science University
2019
Health Sciences Centre
2015-2018
North Carolina State University
2009-2015
University of North Carolina at Chapel Hill
2011-2015
North Central State College
2011-2015
Recent efforts in the area of acoustic droplet vaporization with objective designing extravascular ultrasound contrast agents has led to development stabilized, lipid-encapsulated nanodroplets highly volatile compound decafluorobutane (DFB). We developed two methods generating DFB droplets, first which involves condensing gas (boiling point from -1.1 -2 °C) followed by extrusion a lipid formulation HEPES buffer. Acoustic micrometer-sized lipid-coated droplets at diagnostic frequencies and...
During high-intensity focused ultrasound (HIFU) surgical procedures, there is a need to rapidly ablate pathological tissue while minimizing damage healthy tissue. Current techniques are limited by relatively long procedure times and risks of off-target heating One possible solution the use microbubbles, which can improve efficiency thermal energy delivery during HIFU procedures. However, microbubbles also suffer from limitations such as low spatial selectivity short circulation time in vivo....
view Abstract Citations (170) References (20) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS The Spectra and Rotational Velocities of the Bright Stars Draper Types A3-G0. Slettebak, Arne velocities (v sin i's) have been determined by spectroscopic means for bright stars types , plus a few standards spectral type later than GO. total number considered was 215. Spectral luminosity classes on MK system were estimated all not already standards. principal results...
Phase-change contrast agents (PCCAs) provide a dynamic platform to approach problems in medical ultrasound (US). Upon US-mediated activation, the liquid core vaporizes and expands produce gas bubble ideal for US imaging therapy. In this study, we demonstrate through high-speed video microscopy interrogation that PCCAs composed of highly volatile perfluorocarbons (PFCs) exhibit unique acoustic behavior can be detected differentiated from standard microbubble agents. Experimental results show...
Ultrasound contrast agents are known to enhance high intensity focused ultrasound (HIFU) ablation, but these perfluorocarbon microbubbles limited the vasculature, have a short half-life in vivo, and may result unintended heating away from target site. Herein, nano-sized (100-300 nm), dual (decafluorobutane/dodecafluoropentane) droplet that is stable, sufficiently small extravasate, convertible micron-sized bubbles upon acoustic activation was investigated. Microbubbles nanodroplets were...
Continued advances in the field of ultrasound and contrast agents have created new approaches to imaging medical intervention. Phase-shift perfluorocarbon droplets, which can be vaporized by energy transition from liquid vapor state, are one most highly researched alternatives clinical (i.e., microbubbles). In this paper, part a special issue on methods biomedical ultrasonics, we survey current techniques prepare ultrasound-activated nanoscale phase-shift including sonication, extrusion,...
Perfluorocarbon (PFC) microdroplets, called phase-change contrast agents (PCCAs), are a promising tool in ultrasound imaging and therapy. Interest PCCAs is motivated by the fact that they can be triggered to transition from liquid state gas an externally applied acoustic pulse. This property opens up new approaches applications medicine. Insight into physics of vaporization PFC droplets vital for effective use anticipating bioeffects. composed volatile PFCs (with low boiling point) exhibit...
Ultrasound imaging often calls for the injection of contrast agents, micron-sized bubbles which echo strongly in blood and help distinguish vascularized tissue. Such microbubbles are also being augmented targeted drug delivery gene therapy, by addition surface receptors therapeutic payloads. Unfortunately, conventional production methods yield a polydisperse population, whose nonuniform resonance drug-loading less than ideal. An alternative technique, microfluidic flow-focusing, is able to...
In this study we report on a microfluidic device and droplet formation regime capable of generating clinical-scale quantities emulsions suitable in size functionality for vivo therapeutics. By increasing the capillary number—based flow rate continuous outer phase—in our flow-focusing device, examine three modes breakup: geometry-controlled, dripping, jetting. Operation dripping results generation highly monodisperse liquid perfluoropentane droplets appropriate 3–6 μm range at rates exceeding...
A microfluidic approach for the generation of perfluorocarbon nanodroplets as primary emulsion with diameters small 300-400 nm is described. The system uses a pressure-controlled delivery all reagents and increased viscosity in continuous phase to drive device into an advanced tip-streaming regime, which results droplets sub-micrometer range. Such may be appropriate emerging biomedical applications.