A5042770203- Migraine and Headache Studies
- Neuroscience of respiration and sleep
- Cardiovascular Syncope and Autonomic Disorders
- Transcranial Magnetic Stimulation Studies
- Sympathectomy and Hyperhidrosis Treatments
- Traumatic Brain Injury Research
- Ophthalmology and Eye Disorders
- Cannabis and Cannabinoid Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Neurological disorders and treatments
- Circadian rhythm and melatonin
- Neurosurgical Procedures and Complications
- Pain Management and Treatment
- Diet and metabolism studies
- Infectious Encephalopathies and Encephalitis
- Viral Infections and Immunology Research
- Sleep and related disorders
- Mental Health and Patient Involvement
- Pediatric Pain Management Techniques
- Trigeminal Neuralgia and Treatments
- Cerebral Venous Sinus Thrombosis
- Multiple Sclerosis Research Studies
- Adolescent and Pediatric Healthcare
The University of Texas at Austin
2025
UCSF Benioff Children's Hospital
2019-2023
University of California, San Francisco
2018-2023
Cardinal Glennon Children’s Medical Center
2022
Doernbecher Children's Hospital
2022
Saint Louis University
2022
Universitetshospitalernes Center for Sundhedsfaglig Forskning
2022
University of Illinois Urbana-Champaign
2021
American Headache Society
2020
New York Proton Center
2020
To determine the impact of pediatric-onset multiple sclerosis (MS) on age-expected brain growth.Whole and regional volumes 36 patients with relapsing-remitting MS onset prior to 18 years age were segmented in 185 longitudinal MRI scans (2-11 per participant, 3-month 2-year scan intervals). 25 age- sex-matched healthy normal controls (NC) also acquired at baseline 2 later same scanner as group. A total 874 from 339 participants NIH-funded study development intervals used an growth reference....
Objective To assess the feasibility, tolerability, and patient acceptability of single‐pulse transcranial magnetic stimulation (sTMS) for migraine prevention in adolescents an open‐label pilot study. Background Migraine is common can be disabling. Well tolerated preventative therapies that are safe effective needed. Methods This was prospective feasibility study sTMS aged 12‐17 years. Participants used twice daily a fashion, as well additional pulses needed acutely. A 4‐week baseline run‐in...
The aim of this study was to examine the potential utility a self-paced saccadic eye movement as marker post-concussion syndrome (PCS) and monitoring recovery from PCS. Fifty-nine persistently symptomatic participants with at least two concussions performed saccade (SPS) task. We evaluated relationships between number SPSs 1) self-reported concussion symptoms, 2) integrity major white matter (WM) tracts (as measured by fractional anisotropy [FA] mean diffusivity) that are directly or...
Objective To determine what dose of melatonin is most effective for treating migraine acutely in children and adolescents. Background Acute medications may not work all patients cause side effects. Melatonin prevention adults has been used procedural pain children. Our goal was to whether a “high” or “low” more youth. Methods In this pilot, randomized, open‐label, single‐center, dose‐finding trial, adolescents aged 4‐17 years with episodic were randomized “high‐dose” “low‐dose” (<40 kg: 4...
To evaluate the safety and efficacy of eptinezumab for treatment chronic refractory headache in adolescents.Chronic can lead to school absences impaired quality life adolescents, currently there are no pharmacologic treatments with level A evidence prevention this population. While observational data suggest that monoclonal antibodies calcitonin gene-related peptide or its receptor may be helpful adolescents who have primary disorders, is lacking use eptinezumab.This was a single-center,...
Migraine is a chronic neurological disease manifesting as attacks of disabling head pain and associated symptoms. Remote electrical neuromodulation (REN) non-pharmacological, prescribed, wearable device (Nerivio®). This has been certified by the FDA for acute and/or preventive treatment migraine with or without aura in patients 12 years age older. The affixed to user's arm during 45-min sessions operated using smartphone app. study (NCT05769322) aims evaluate whether frequent use REN...
Abstract Objective There is an unmet need for new, efficacious, well-tolerated, acute treatments migraine in adolescents. Remote electrical neuromodulation (REN) a novel, nonpharmacological treatment that provides significant symptom relief with good tolerability. The current post hoc analysis compared the efficacy of REN to standard-care medications Design Within-participant data from clinical trial. Setting Data Subjects 35 adolescent participants were analyzed. Methods Efficacy was...
Abstract Background Melatonin is effective for migraine prevention in adults. We hypothesized that melatonin would also be children and adolescents. Methods This was a randomized, double‐blind trial of (3 mg or 6 mg) versus placebo 10–17 year‐olds with 4–28/28 headache days at baseline. Participants were recruited from the UCSF Child & Adolescent Headache Program, child neurology clinic, social media advertisements. Migraine diagnosis confirmed by specialist. completed an 8‐week...
Objective To investigate whether later high school start time is associated with lower migraine frequency in students migraine. Background Adequate sleep thought to be important managing adolescent The American Academy of Sleep Medicine recommends teenagers ≥8 hours/night. Adolescents have a physiologically delayed phase, going bed, and waking than children adults. Pediatrics (AAP) accordingly schools no earlier 8:30 AM. Methods Cross‐sectional observational study U.S. schoolers Participants...
To determine whether high school start time is associated with headache frequency in adolescents migraine.Adolescence marked by a physiologic delayed circadian phase, characterized later bedtimes and wake times. The American Academy of Pediatrics (AAP) recommends that schools no earlier than 8:30 a.m., but most the United States earlier. study hypothesis was migraine whose at a.m. or (late group) would have lower those (early group).This cross-sectional Internet survey US schoolers recruited...
Introduction Cannabis products have been used in the management of headaches adults and may play a role pediatric chronic pain. Canadian pediatricians report increasing use cannabis for headaches, despite no well-controlled studies to inform its dosing, safety, effectiveness. The aim our clinical trial is determine dosing safety Cannabidiol (CBD)-enriched Herbal Extract (CHE) treatment adolescents. Methods analysis Youth, parents, an expert steering committee co-designed this tolerability...
<h3>Background and Objectives</h3> Children adolescents with chronic migraine who have continuous headache may high levels of headache-related disability but largely been excluded from clinical trials. Understanding patient-valued treatment outcomes facilitate future study design. The aim this work was to identify outcome measures for preventive treatments among due their parents. <h3>Methods</h3> Adolescents an International Classification Headache Disorders, 3rd edition diagnosis migraine,...
To date, there have not been reliable biomarkers to identify impending migraine episodes. A prior study in adults with demonstrated a reduction the urinary metabolic substrate of melatonin (urinary 6-sulfatoxymelatonin; aMT6s) during migraine. The aim this was examine whether evening metabolite levels could predict next day children and adolescents migraine.Twenty-one (aged 5-17 years) were recruited observational conducted at UC San Francisco provide urine samples for 10 days maintain...