A5041854502- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Genetics and Neurodevelopmental Disorders
- Neurological disorders and treatments
- Neonatal and fetal brain pathology
- Nerve injury and regeneration
- Clinical Nutrition and Gastroenterology
- Autism Spectrum Disorder Research
- Infectious Encephalopathies and Encephalitis
- Muscle and Compartmental Disorders
- Vitamin C and Antioxidants Research
- Nuclear Structure and Function
- Alcoholism and Thiamine Deficiency
- EEG and Brain-Computer Interfaces
- Genomics and Rare Diseases
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Adolescent and Pediatric Healthcare
- Migration, Health, Geopolitics, Historical Geography
- Colorectal Cancer Surgical Treatments
Garrahan Hospital
2014-2024
University of Chile
2023
Hospital Provincial de Rosario
2023
Krembil Research Institute
2016-2018
University Health Network
2016-2018
Atuka (Canada)
2018
Toronto Western Hospital
2008-2010
Hospital de Sant Pau
1995
Hospital San Juan de la Cruz
1991
Recent failures in clinical trials for disease modification Parkinson's have highlighted the need a non-human primate model of synucleinopathy underpinning dopaminergic neuron degeneration. The present study was defined to begin development such cynomolgus macaque. We validated surgical and vector parameters define means provide robust over-expression alpha-synuclein which is associated with Lewy-like pathology degeneration nigrostriatal pathway. Thus, an AAV1/2 incorporating strong...
Introduction: Epilepsy is a neurological disorder characterized by an increased susceptibility to seizures. The ketogenic diet (KD) currently the most important alternative non-pharmacological treatment. Despite its long history of clinical use, it not clear how this affects longitudinal growth in children. Methods: A prospective study was designed evaluate and nutritional status 45 children on KD. Growth assessed measuring weight, height, body mass index (BMI). Standard deviation scores...
Abstract Growing interest in the clinical use of cannabidiol (CBD) as adjuvant therapy for pediatric refractory epileptic encephalopathy emphasizes need drug treatment optimization. The aim this study was to characterize pharmacokinetics CBD patients with receiving an oil‐based oral solution. To evaluate concentrations, six serial blood samples per patient were collected after morning dose CBD, at least 21 days beginning treatment. Twelve who received a median (range) 12.2 (5.3‐19.4) mg/kg/d...
Journal Article Diagnosis of retained abdominal gauze swabs Get access F X Botet Del Castillo, Castillo Unitat de Cirurgia Digestiva and Servei General i Digestiva, Hospital la Santa Creu Sant Pau, Barcelona, Spain Correspondence to: Dr F. X. del Ferran 60, lgualada 08700, Search for other works by this author on: Oxford Academic Google Scholar S López, López G Reyes, Reyes R Salvador, Salvador J M Llauradó, Llauradó Peñalva, Peñalva Trias British Surgery, Volume 82, Issue 2, February 1995,...
Epilepsy of infancy with migrating focal seizures (EIMFS) is a rare epilepsy syndrome, characterized by an onset multifocal before the age six months and rather typical ictal EEG pattern. The ketogenic diet (KD) has been shown to be treatment option in these patients variable results. KD generally given enteral formula or solid food, however, on often have coexisting medical disorders that may impair gastrointestinal tract and, cases, parenteral nutrition support needed. We present our...
To describe a series of patients with drug resistant epilepsy treated vagus nerve stimulation in national pediatric hospital, evaluating efficacy, safety and tolerability.A retrospective analysis 158 to pharmacological non treatment including surgery that were between 2001-2015. Patients progressive encephalopathies, congenital heart disease excluded.158 (80 male) included, mean age at implantation 11.4 years evolution 9.5 years. Time follow-up: 1-15 (median: 6.9 years). Patient's this time:...
Abstract Mutations in the PRRT2 gene lead to a spectrum of diseases with common pathophysiology including self-limited (familial) infantile epilepsy and paroxysmal kinesigenic dyskinesia as well other involving movement headache disorders. Atypical phenotypes, associated episodic ataxia, epilepsy, hemiplegic migraine, developmental delay, intellectual disability, have been reported approximately 5% patients, which is probably an underestimation. Here, we present three patients variable...