A5008715025- Cannabis and Cannabinoid Research
- Epilepsy research and treatment
- Viral Infections and Vectors
- Metabolomics and Mass Spectrometry Studies
- Trypanosoma species research and implications
- Pharmacological Effects and Toxicity Studies
- Neonatal Health and Biochemistry
- Analytical Chemistry and Chromatography
- Toxoplasma gondii Research Studies
- Medical and Biological Sciences
- Neuroscience and Neuropharmacology Research
- Healthcare Systems and Public Health
- Heme Oxygenase-1 and Carbon Monoxide
Hospital General de Niños Ricardo Gutierrez
2020-2025
Ministerio de Salud
2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2020-2023
Centro Científico Tecnológico - San Juan
2020
Abstract Objective Identifying factors influencing cannabidiol (CBD) exposure can optimize treatment efficacy and safety. We aimed to describe the population pharmacokinetics of CBD in children with drug‐resistant developmental epileptic encephalopathies (DEEs) assess influence environmental, pharmacological, clinical characteristics on systemic exposure. Methods Data from two pharmacokinetic studies patients aged 2–18 years DEEs were included ( N = 48 patients). Serial blood samples...
Abstract Growing interest in the clinical use of cannabidiol (CBD) as adjuvant therapy for pediatric refractory epileptic encephalopathy emphasizes need drug treatment optimization. The aim this study was to characterize pharmacokinetics CBD patients with receiving an oil‐based oral solution. To evaluate concentrations, six serial blood samples per patient were collected after morning dose CBD, at least 21 days beginning treatment. Twelve who received a median (range) 12.2 (5.3‐19.4) mg/kg/d...
Background: Cannabidiol (CBD) is a nonpsychoactive natural product that has been increasingly used as promising new drug for the management of neurological conditions such refractory epilepsy. Development rapid and sensitive methods to quantitate CBD essential evaluate its pharmacokinetics in humans, particularly children. The objective this work was develop validate an ultrafast ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) method...
The identification of factors that affect cannabidiol (CBD) systemic exposure may aid in optimizing treatment efficacy and safety clinical practice. In this study, we aimed to correlate CBD plasma concentrations at a steady state demographic, clinical, pharmacological characteristics as well seizure frequency after the administration purified oil solution real-world setting children with drug-resistant developmental epileptic encephalopathies (DEEs). Patients receiving oral pharmaceutical...
Infection with Toxoplasma gondii, is one of the most widespread zoonoses in world. Congenital Toxoplasmosis (CT) particularly risky due to its fetal complications. Sulfadiazine (SDZ) and Pyrimethamine (PYR) are usually used for CT treatment Argentina, prevent morbidity. Due lack commercial pediatric formulations, these must be prepared hospital pharmacy. This first report serum concentrations measures therapy this combination drugs. A bioanalytical method was developed identification...