A5062938106- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Synthesis and Biological Evaluation
- Reproductive tract infections research
- Syphilis Diagnosis and Treatment
- Parasites and Host Interactions
- Parasitic infections in humans and animals
- Viral-associated cancers and disorders
- Cardiovascular Issues in Pregnancy
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Amoebic Infections and Treatments
- Toxoplasma gondii Research Studies
- Breastfeeding Practices and Influences
- Sex work and related issues
- Congenital Anomalies and Fetal Surgery
- Parasitic Diseases Research and Treatment
- Histiocytic Disorders and Treatments
- Pharmaceutical studies and practices
- Child and Adolescent Health
- Public Health and Environmental Issues
- Insect symbiosis and bacterial influences
- Lysosomal Storage Disorders Research
- Drug-Induced Adverse Reactions
- Parvovirus B19 Infection Studies
Consejo Nacional de Investigaciones Científicas y Técnicas
2019-2025
Hospital General de Niños Ricardo Gutierrez
2014-2024
Children's Hospital
2024
Ministerio de Salud
2023
Hospital del Niño
2022
Instituto Multidisciplinario de Biología Vegetal
2019
Boston Children's Hospital
2013-2015
BACKGROUND: Chagas disease is caused by infection with Trypanosoma cruzi. In adults, treatment benznidazole associated a high incidence of adverse drug reactions (ADRs). However, in infants and children, seems lower decreased severity ADRs, but these effects have not been clearly characterized. OBJECTIVE: We aimed to describe ADRs observed children treated benznidazole. PATIENTS AND METHODS: conducted prospective cohort study Argentina RESULTS: A total 107 diagnosed asymptomatic (mean age:...
Introduction Chagas disease, caused by the parasite Trypanosoma cruzi, can lead to long term cardiac morbidity. Treatment of children with benznidazole is effective, but no pediatric pharmacokinetics data are available and clinical pharmacology information on drug scarce. Patients Methods Prospective population pharmacokinetic (PK) cohort study in 2–12 years old disease treated oral 5–8 mg/kg/day BID for 60 days. (clinicaltrials.gov #NCT00699387). Results Forty were enrolled study. Mean age...
It is currently unknown whether treatment of Chagas disease decreases the risk congenital transmission from previously treated mothers to their infants. In a cohort women with benznidazole, no was observed in newborns. This finding provides support for as early possible.
The diagnosis of congenital Chagas disease in newborns relies on the microhematocrit method which exhibits reduced sensitivity during early stages infection and quantitative PCR for Trypanosoma cruzi, is applied only specialised centre due to its technical complexity. Consequently, majority transmission cases are confirmed after an extended period serological monitoring, resulting delayed treatments cure rates. need new, accurate tests timely evident. We developed a lateral flow assay based...
Background Evaluation of therapeutic response in chronic Chagas disease is a major challenge, due to prolonged persistence Trypanosoma cruzi-specific antibodies, lack sensitivity parasitological tests, and need for long-term follow-up observe negative seroconversion conventional serological tests (CS). The objective this study was evaluate F2/3-ELISA serology, promising early biomarker response, T.cruzi Polymerase chain reaction (PCR) T. cruzi Deoxyribonucleic acid (DNA), neonatal diagnosis...
Chagas disease (ChD), caused by Trypanosoma cruzi, has a global prevalence due to patient migration. However, despite its worldwide distribution, long-term follow-up efficacy studies with nifurtimox (NF) are scarce and have been conducted only small numbers of patients. A retrospective study large cohort ChD treated children adults NF. Treatment response was evaluated clinical, parasitological, serological after-treatment evaluation. total 289 patients were enrolled, which 199 90 adults. At...
Background Benznidazole (BNZ) is safe and effective for the treatment of paediatric Chagas disease. Treatment adults also in many cases, but discouraged breastfeeding women because no information on BNZ transfer into breast milk available. We aimed to evaluate degree lactating with Patients methods Prospective cohort study disease treated administered 30 days. their breastfed infants were evaluated at admission, 7th 30th day (and monthly thereafter, 6 months). was measured plasma by high...
Background In regions with controlled vector transmission of T . cruzi , congenital is the most frequent route infection. Treatment benznidazole (BZ) or nifurtimox (NF) for 60 days in girls and women childbearing age showed to be effective preventing mother child this disease. Reports on short-course treatment (≤30 days) are scarce. Methods Retrospective cohort study. Offspring Chagas disease who received BZ NF, attended between 2003 2022, were evaluated. Parasitemia (microhaematocrit and/or...
Background There is a major need for information on pharmacokinetics (PK) of benznidazole (BNZ) in children with Chagas disease (CD). We conducted multicentre population PK, safety and efficacy study children, infants neonates CD treated BNZ (formulated 100 mg tablets or 12.5 dispersible tablets, developed by the pharmaceutical company LAFEPE, collaboration DNDi). Methods 81 0–12 years old were enrolled at 5 pediatric centers Argentina. Diagnosis T . cruzi infection was confirmed direct...
Nifurtimox (NF) is one of the only two drugs currently available for Chagas disease (ChD) treatment. However, data on NF safety are scarce, and many physicians defer or refuse treatment because concerns about drug tolerance. In a retrospective study adverse reactions (ADRs) associated with ChD, children received doses 10 to 15 mg/kg/day 60 90 days, adults 8 30 days. A total 215 (median age, 2.6 years; range, 0 17 years) 105 34 18 57 were enrolled. Overall, 127/320 (39.7%) patients developed...
Abstract Epstein–Barr virus (EBV) is related to the development of lymphomas and also etiological agent for infectious mononucleosis (IM). Sequence variation EBNA1 gene, consistently expressed in all EBV‐positive cells, has been widely studied. Based on amino acid at codon 487 five major variants have described, two closely prototypic (P‐ala P‐thr) three variant sequences (V‐leu, V‐val, V‐pro). Sub‐variants were then further classified based mutations other than originally described. While...
ABSTRACT Chagas disease is caused by the protozoan parasite Trypanosoma cruzi . Assessment of parasitological cure upon treatment with available drugs relies on achieving consistent negative results in conventional and serological tests, which may take years to assess. Here, we evaluated use a recombinant T. antigen termed trypomastigote small surface (TSSA) as an early marker drug efficacy -infected children. A cohort 78 pediatric patients born mothers was included this study. Only 39...
Treatment with nifurtimox (NF) for Chagas disease is discouraged during breast-feeding because no information on NF transfer into breast milk available. safe and effective paediatric adult disease. We evaluated the degree of in lactating women
Cystic echinococcosis is endemic in Argentina. The standard pharmacological treatment for the disease albendazole, but surgery a common alternative. Even though primary infection occurs mainly pediatric population, optimal therapeutic option pediatrics not clearly defined and few cohorts with cystic treated albendazole have been described to date.To describe response cohort of patients abdominal echinococcosis.Patients (0-18 years old) who were between January 1998 August 2013. Diagnosis was...
In spite of being preventable, Congenital syphilis (CS) is still an important, and growing health problem worldwide. Fetal infection can be particularly aggressive, but newborns asymptomatic at birth and, if left untreated, develop systemic compromise afterwards with poor prognosis. We analyzed 61 CS diagnosis cases between 1987–2019 presenting the Buenos Aires Children’ Hospital. The distribution showed a bimodal curve, peak in 1992–1993 2014–2017. Median age was 2 months (IQ 1–6 months)....
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The presence of autoantibodies with adrenergic and cholinergic activity, capable triggering neurotransmitter receptor-mediated effects, has been associated pathogenesis in T. cruzi-infected hosts. goal this study was to investigate the production anti-M2 muscarinic receptor (Anti-M2R AAbs) as well IFN-γ profile children at early stage Chagas disease, examine whether trypanocidal chemotherapy benzonidazole (BZ) could modify both response patterns.This comprised 30 (mean age: 13.8 years) 19...
Abstract Background No reliable tests or validated biomarkers exist to ensure parasitological cure following treatment of Chagas disease (CD) patients chronically infected with Trypanosoma cruzi. As seroreversion, the only marker cure, happens more quickly in children, we investigated correlation between previously identified and seroreversion children. Methods Thirty CD children (age 1 month 10 years) diagnosed as T. cruzi positive (time point S0) were treated benznidazole (BZ) 5–8 mg/kg/d...
Chagas disease (ChD) affects approximately 7 million people in Latin America, with benznidazole being the most commonly used treatment.
The primary objective of this study was to estimate the prevalence disease in women childbearing age and children treated at health centres underserviced areas city Buenos Aires. Demographic Chagas status data were collected. Samples for serology obtained on filter paper reactive results confirmed with conventional samples. A total 1,786 subjects screened 73 positive screening obtained: 17 from 56 women. Trypanosoma cruzi infection risk greater those individuals who had relatives disease,...
Abstract Epstein–Barr virus genotypes can be distinguished by polymorphic variations in the genes encoding EBNA2, 3A, 3B, and 3C. The immediate early gene BZLF1 plays a key role modulating switch from latency to lytic replication therefore enabling viral propagation. aim of this study was investigate compare promoter sequence (Zp) variation pediatric infectious mononucleosis (IM) EBV positive lymphoma biopsies. Zp sequenced peripheral blood mononuclear cells (PBMC) throat swabs 10 patients...
Hydatidosis is a zoonosis of worldwide distribution caused by the parasite Echinococcus granul osus. Clinical manifestations include cyst formation, most commonly in liver (67–89%) and lungs (10–15%). Renal localizations are rare. We report case renal hydatidosis five-year-old child treated tertiary pediatric hospital Argentina. After diagnosis was made, elective surgery performed, which led to rapid recovery.