A5054313572- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Synthesis and Biological Evaluation
- Breastfeeding Practices and Influences
- Parasitic Diseases Research and Treatment
- Cardiovascular Issues in Pregnancy
- Viral Infections and Vectors
- Social and Economic Solidarity
- Toxoplasma gondii Research Studies
- Insect-Plant Interactions and Control
- Analytical Chemistry and Sensors
- Healthcare Systems and Public Health
- Insect and Pesticide Research
- Communication and COVID-19 Impact
- Biochemical and Molecular Research
- Lysosomal Storage Disorders Research
- Heme Oxygenase-1 and Carbon Monoxide
- Occupational Health and Safety in Workplaces
- Electrochemical Analysis and Applications
- Drug-Induced Hepatotoxicity and Protection
- Electrochemical sensors and biosensors
- Ionic liquids properties and applications
- Helminth infection and control
- Analytical chemistry methods development
- Business, Innovation, and Economy
Universidad Nacional de La Plata
2013-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2020-2025
Comisión de Investigaciones Científicas
2013-2021
Centro Científico Tecnológico - La Plata
2021
Introduction Chagas disease, caused by the parasite Trypanosoma cruzi, can lead to long term cardiac morbidity. Treatment of children with benznidazole is effective, but no pediatric pharmacokinetics data are available and clinical pharmacology information on drug scarce. Patients Methods Prospective population pharmacokinetic (PK) cohort study in 2–12 years old disease treated oral 5–8 mg/kg/day BID for 60 days. (clinicaltrials.gov #NCT00699387). Results Forty were enrolled study. Mean age...
Pharmacological treatment of Chagas disease with benznidazole (BNZ) is effective in children all stages, but it controversial chronically infected adults. We report the pharmacokinetics and pharmacodynamics six adult patients treated new BNZ formulation (ABARAX®) doses between 2.5-5.5 mg/Kg/day. All one patient had plasmatic concentrations within expected range. finalised nondetectable Trypanosoma cruziquantitative polymerase chain reaction, which remained at month follow-up. Our data...
Benznidazole (BNZ) is the primary treatment for Chagas disease. While pharmacokinetic studies of BNZ began in 1970s, its metabolism and excretion are not fully understood. Alternatives like Benznidazol Lafepe® Abarax® have replaced original Radanil®. To compare profiles both currently available formulations adults with chronic Trypanosoma cruzi infection. The study involved 13 subjects each one receiving 100 mg presentations week apart. Blood samples were collected over 48 hours...
Background Benznidazole (BNZ) is safe and effective for the treatment of paediatric Chagas disease. Treatment adults also in many cases, but discouraged breastfeeding women because no information on BNZ transfer into breast milk available. We aimed to evaluate degree lactating with Patients methods Prospective cohort study disease treated administered 30 days. their breastfed infants were evaluated at admission, 7th 30th day (and monthly thereafter, 6 months). was measured plasma by high...
Treatment with nifurtimox (NF) for Chagas disease is discouraged during breast-feeding because no information on NF transfer into breast milk available. safe and effective paediatric adult disease. We evaluated the degree of in lactating women
Objective Chagas disease constitutes a major public health problem in Latin America. Correctly designed pharmacokinetic, safety, and bioequivalence studies are desirable order to fill the knowledge gaps that presently exist on available drugs. It is necessary develop accurate, simple, reproducible, sensitive high‐performance liquid chromatography (HPLC)/UV methods for quantization of benznidazole (BNZ) human plasma urine clinical applications, specially pediatric patients. Methods...
Background: Due to migration, Chagas disease is a significant public health problem in Latin America, and other nonendemic regions.The 2 drugs currently available for the treatment, nifurtimox benznidazole (BNZ), are associated with high risk of toxicity therapeutic doses.Excretion drug into human breast milk potential source unwanted exposure pharmacologic effects nursing infant.However, this phenomenon was not evaluated until now, measurement techniques both were developed. Methods:In...
Chagas disease reactivation in HIV-positive people is an opportunistic infection with 79 to 100% mortality. It commonly involves the central nervous system (CNS). Early treatment trypanocidal drugs such as benznidazole (BNZ) crucial for this severe manifestation of Trypanosoma cruzi infection. However, limited BNZ clinical pharmacology data are available, especially its concentration CNS. We report a series patients undergoing T. meningoencephalitis, their response, and cerebrospinal fluid...
Chagas disease is a serious public health problem in Latin America and, due to migration, other non-endemic regions. Benznidazole (BNZ) first choice drug pediatric therapeutics. However, little known regarding its metabolism humans. The aim of the study was isolate and identify products human BZN urine samples obtained from patient healthy adult volunteer both treated with BZN. Urine were collected after dose BNZ. β-glucuronidase followed by an extraction procedure under two different pH...
Desde un enfoque pedagógico emancipatorio, buscamos describir y problematizar los procesos de aprendizaje-enseñanza constituidos hecho extracurricularmente desde la Facultad Ciencias Exactas Universidad Nacional La Plata (FCE - UNLP), ante emergencia sanitaria por COVID-19 entre estudiantes, graduades, docentes las personas en sus comunidades. De intervenciones llevadas adelante equipos salud conformados multidisciplinar e interinstitucionalmente, se configuraron esquemas dispositivos...
Infection with Toxoplasma gondii, is one of the most widespread zoonoses in world. Congenital Toxoplasmosis (CT) particularly risky due to its fetal complications. Sulfadiazine (SDZ) and Pyrimethamine (PYR) are usually used for CT treatment Argentina, prevent morbidity. Due lack commercial pediatric formulations, these must be prepared hospital pharmacy. This first report serum concentrations measures therapy this combination drugs. A bioanalytical method was developed identification...