A5056400332- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Epilepsy research and treatment
- Glycogen Storage Diseases and Myoclonus
- Diet, Metabolism, and Disease
- Obesity, Physical Activity, Diet
- Child Nutrition and Feeding Issues
- Breastfeeding Practices and Influences
- Vitamin C and Antioxidants Research
- Pharmacology and Obesity Treatment
- Infant Nutrition and Health
- Health and Lifestyle Studies
- Clinical Nutrition and Gastroenterology
- Alcoholism and Thiamine Deficiency
- Digestive system and related health
- Neonatal Health and Biochemistry
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Obesity and Health Practices
- Viral gastroenteritis research and epidemiology
- Folate and B Vitamins Research
- Neurological and metabolic disorders
- Diabetes Treatment and Management
- Genetics and Neurodevelopmental Disorders
- Vitamin D Research Studies
Garrahan Hospital
2016-2025
Centro de Investigaciones Cardiovasculares
2024
Instituto de Diagnóstico e Investigaciones Metabólicas
2024
Federico II University Hospital
2024
Glut1 deficiency syndrome (Glut1DS) is a brain energy failure caused by impaired glucose transport across tissue barriers. Glucose diffusion barriers facilitated family of proteins including transporter type 1 (Glut1). Patients are treated effectively with ketogenic diet therapies (KDT) that provide supplemental fuel, namely ketone bodies, for metabolism. The increasing complexity Glut1DS, since its original description in 1991, now demands an international consensus statement regarding...
The term "ketogenic diet" (KD) is used for a wide variety of diets with diverse indications ranging from obesity to neurological diseases, as if it was the same diet.This terminology confusing patients and medical scientific community.The "ketogenic" diet implies dietary regimen characterized by increased levels circulating ketone bodies that should be measured in blood (beta-hydroxybutyrate), urine (acetoacetate) or breath (acetone) verify metabolic condition".Our viewpoint highlights KDs...
Abstract Objective Identifying factors influencing cannabidiol (CBD) exposure can optimize treatment efficacy and safety. We aimed to describe the population pharmacokinetics of CBD in children with drug‐resistant developmental epileptic encephalopathies (DEEs) assess influence environmental, pharmacological, clinical characteristics on systemic exposure. Methods Data from two pharmacokinetic studies patients aged 2–18 years DEEs were included ( N = 48 patients). Serial blood samples...
Abstract Aim . We describe two patients with refractory myoclonic status epilepticus treated the ketogenic diet. Methods Between May 1, 2014 and January 2015, who met diagnostic criteria for epilepticus, seen at our department, were placed on diet followed a minimum of six months. Results One patient epilepsy unknown aetiology had 75–90% seizure reduction, other progressive encephalopathy associated 50% reduction. Both retained good tolerability At last control, one isolated myoclonias EEG...
Introduction: Epilepsy is a neurological disorder characterized by an increased susceptibility to seizures. The ketogenic diet (KD) currently the most important alternative non-pharmacological treatment. Despite its long history of clinical use, it not clear how this affects longitudinal growth in children. Methods: A prospective study was designed evaluate and nutritional status 45 children on KD. Growth assessed measuring weight, height, body mass index (BMI). Standard deviation scores...
Abstract Ketogenic diet therapy (KDT) is a safe and effective treatment for epilepsy glucose transporter type 1 (GLUT1) deficiency syndrome in infancy. Complete weaning from breastfeeding not required to implement KDT; however, remains uncommon. Barriers include feasibility concerns lack of referrals expert centres. Therefore, practical strategies are needed help mothers professionals overcome these barriers facilitate the inclusion human milk during KDT. A multidisciplinary panel met online...
The epidemic of childhood obesity is associated with early atherosclerosis. Several reports have related this event to low-grade inflammation described in obesity. CRP and IL6 are markers that correlate adiposity. waist-to-height ratio (WtHR) an anthropometric marker insulin resistance inflammation. objective study was assess the correlation between WtHR, metabolic complications pro-inflammatory factors obese children adolescents.Weight, height, waist circumference, glycemia, insulin, CRP,...
Abstract Objective There is growing evidence that ketogenic dietary therapy (KDT) can be safely and efficiently used in young children, but little exists on its use newborns. Developmental epileptic encephalopathies starting the neonatal period or early infancy usually present a poor prognosis. The aim of this study was to evaluate effectiveness, safety, survival infants younger than 3 months age with drug‐resistant epilepsy whom KDT used. Methods A retrospective conducted neonates who...
Hyperinsulinemia increases the risk of cardiovascular disease in obese children. Only a few treatments are available to decrease insulin resistance. The reduction hyperinsulinemia by dietary means would be simple, physiologic and economic way reduce metabolic disease.
Breastfeeding is recommended as the best source of nutrition in first months life and observational studies have associated exclusive breastfeeding with decreased weight gain a protective effect against obesity childhood. The objective this study was to describe characteristics cohort exclusively breastfed obese infants determine factors that may lead unusual gain.Infants seen between 2003 2015 who were showed excessive year followed focus on features mother, child, feeding patterns presence...
Epilepsy is a chronic disease with onset in infancy affecting 0.5-1% of the population. One third patients refractory to antiepileptic drugs and they pose challenge for health care team. The ketogenic diet an effective, non-pharmacological, alternative treatment management epilepsy.There need establish guidelines adequate increased use Spanish-speaking countries. National Committee on Ketogenic Diet, consisting paediatric neurologists, clinical nutritionists, dietitians, Argentine Society...
Epilepsy of infancy with migrating focal seizures (EIMFS) is a rare epilepsy syndrome, characterized by an onset multifocal before the age six months and rather typical ictal EEG pattern. The ketogenic diet (KD) has been shown to be treatment option in these patients variable results. KD generally given enteral formula or solid food, however, on often have coexisting medical disorders that may impair gastrointestinal tract and, cases, parenteral nutrition support needed. We present our...
The ketogenic diet, a non-drug treatment with proven effectiveness, has been the most commonly used therapy in past decade for management of refractory epilepsy pediatric population.Compared to adding new drug pre-existing treatment, diet is highly effective and reduces number seizures by 50-90% approximately 45-60% children after six months treatment.For this reason, Argentine Society Pediatric Neurology established Ketogenic Diet Working Group.It integrated dietitians, pediatricians,...
The ketogenic diet is a non-pharmacological treatment that has been used as therapeutic alternative for the management of refractory epilepsy since 1921. It diet, high in fats and low carbohydrates, which to treat paediatric epilepsy, effective around 50% patients begin follow it. nutrition plan imbalanced terms both macro- micro-nutrients, can give rise nutritional deficits energy, proteins, minerals vitamins, well an excess lipids. There therefore risk it causing undesirable side effects...