A5062994371- Epilepsy research and treatment
- Neurological disorders and treatments
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Memory and Neural Mechanisms
- Pain Management and Treatment
- Motor Control and Adaptation
- Vagus Nerve Stimulation Research
- Neuroscience and Neural Engineering
- Obstructive Sleep Apnea Research
- Hemispheric Asymmetry in Neuroscience
- Sleep and Wakefulness Research
- Neuroscience and Music Perception
- Pharmacological Effects and Toxicity Studies
- Visual perception and processing mechanisms
- Hearing Loss and Rehabilitation
- Botulinum Toxin and Related Neurological Disorders
- Neural Networks and Reservoir Computing
- Tactile and Sensory Interactions
- Neurology and Historical Studies
- Fetal and Pediatric Neurological Disorders
California Pacific Medical Center
2015-2025
Yale University
2022-2025
Eisai (Japan)
2012
Summary Objective To demonstrate the safety and effectiveness of responsive stimulation at seizure focus as an adjunctive therapy to reduce frequency seizures in adults with medically intractable partial onset arising from one or two foci. Methods Randomized multicenter double‐blinded controlled trial focal cortical (RNS System). Subjects foci were implanted, 1 month postimplant randomized 1:1 active sham stimulation. After fifth month, all subjects received open label period ( OLP )...
The long-term efficacy and safety of responsive direct neurostimulation was assessed in adults with medically refractory partial onset seizures.All participants were treated a cranially implanted neurostimulator that delivers stimulation to 1 or 2 seizure foci via chronically electrodes when specific electrocorticographic patterns are detected (RNS System). Participants had completed 2-year primarily open-label study (n = 65) randomized blinded controlled 191); 230 transitioned into an...
Epilepsy is defined by the seemingly random occurrence of spontaneous seizures. The ability to anticipate seizures would enable preventative treatment strategies. A central but unresolved question concerns relationship seizure timing fluctuating rates interictal epileptiform discharges (here termed activity, IEA), a marker brain irritability observed between electroencephalography (EEG). Here, in 37 subjects with an implanted stimulation device that detects IEA and over years, we find...
<h3>Objective:</h3> To assess efficacy and safety of once-daily 8 or 12 mg perampanel, a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, when added to concomitant antiepileptic drugs (AEDs) in the treatment drug-resistant partial-onset seizures. <h3>Methods:</h3> This was multicenter, double-blind, placebo-controlled trial (ClinicalTrials.gov identifier: NCT00699972). Patients (≥12 years, with ongoing seizures despite 1–3 AEDs) were randomized...
Summary Objective Evaluate the seizure‐reduction response and safety of mesial temporal lobe ( MTL ) brain‐responsive stimulation in adults with medically intractable partial‐onset seizures origin. Methods Subjects epilepsy MTLE were identified from prospective clinical trials a neurostimulator RNS System, NeuroPace). The seizure reduction over years 2–6 postimplantation was calculated by assessing frequency compared to preimplantation baseline. Safety assessed based on reported adverse...
Summary Objective Evaluate the seizure‐reduction response and safety of brain‐responsive stimulation in adults with medically intractable partial‐onset seizures neocortical origin. Methods Patients partial origin were identified from prospective clinical trials a neurostimulator (RNS System, NeuroPace). The seizure reduction over years 2–6 postimplantation was calculated by assessing frequency compared to preimplantation baseline. Safety assessed based on reported adverse events. Additional...
Patients with suspected mesial temporal lobe (MTL) epilepsy typically undergo inpatient video-electroencephalography (EEG) monitoring scalp and/or intracranial electrodes for 1 to 2 weeks localize and lateralize the seizure focus or foci. Chronic ambulatory electrocorticography (ECoG) in patients MTL may provide additional information about lateralization. This analysis describes data obtained from chronic ECoG bilateral order assess time required determine lateralization whether this could...
Word retrieval is core to language production and relies on complementary processes: the rapid activation of lexical conceptual representations word selection, which chooses correct among semantically related competitors. Lexical measured by semantic priming. In contrast, selection indexed interference hampered in homogeneous (HOM) contexts. We examined spatiotemporal dynamics these processes a picture naming task with blocks heterogeneous (HET) or HOM stimuli. used electrocorticography data...
Neurophysiological studies in humans and nonhuman primates have revealed movement representations both the contralateral ipsilateral hemispheres. Inspired by clinical observations, we ask if this bilateral representation differs for left right Electrocorticography was recorded human participants during an instructed-delay reaching task, with movements produced either or arm. Using a cross-validated kinematic encoding model, found stronger hemisphere, effect that present preparation amplified...
How does the human brain rapidly process incoming information in working memory? In growing divergence from a single-region focus on prefrontal cortex (PFC), recent work argues for emphasis how distributed neural networks are coordinated support of this central neurocognitive function. Previously, we showed that memory everyday "what," "where," and "when" associations depends multiplexed oscillatory systems, which signals different frequencies simultaneously link PFC to parieto-occipital...
Summary Declarative memory depends on the coordination of local processing, indexed by high-frequency broadband (HFB) activity, with global network organization, theta oscillations. However, and HFB exhibit asynchronous timing, raising question how results processing are communicated throughout network. Using intracranial EEG in patients performing a recognition task, we examined this across medial temporal lobe (MTL) prefrontal cortex (PFC). peak activity was earlier MTL than PFC. Anchoring...
Goal-directed behavior requires adjusting cognitive control to both react and prepare for conflict. Previous work indicates theta oscillations population activity in dorsomedial prefrontal cortex (dmPFC) dorsolateral (dlPFC) are critical reactive control. However, the neural mechanisms supporting proactive less clear. Here, we investigated basis of behavioral adaptations when is prepared anticipation conflict using intracranial EEG (iEEG) dmPFC dlPFC during a Stroop task where frequency was...
Episodic memory relies on the formation and retrieval of content-specific traces. In addition to their veridical reactivation, previous studies have indicated that traces may undergo substantial transformations. However, exact time course regional distribution reinstatement transformation during recognition remained unclear. We applied representational similarity analysis human intracranial electroencephalography track spatiotemporal dynamics underlying Specifically, we examined how...
Abstract The signed value and unsigned salience of reward prediction errors (RPEs) are critical to understanding reinforcement learning (RL) cognitive control. Dorsomedial prefrontal cortex (dMPFC) insula (INS) key regions for integrating surprise information, but conflicting evidence both activity has led multiple proposals the nature RPE representations in these brain areas. Recently developed RL models allow neurons respond differently positive negative RPEs. Here, we use intracranially...
Abstract Flexible behavior requires gating mechanisms that encode only task-relevant information in working memory. Extant literature supports a theoretical division of labor whereby lateral frontoparietal interactions underlie maintenance and the striatum enacts gate. Here, we reveal neocortical intracranial EEG patients by identifying rapid, within-trial changes regional inter-regional activities predict subsequent behavioral outputs. Results first demonstrate accumulation extend prior...
The auditory cortex is well-known to be critical for music perception, including the perception of consonance and dissonance. Studies on neural correlates dissonance have largely employed non-invasive electrophysiological functional imaging techniques in humans as well neurophysiological recordings animals, but fine-grained spatiotemporal dynamics within human remain unknown. We recorded electrocorticographic (ECoG) signals directly from lateral surface either left or right temporal lobe...
Status epilepticus (SE) is a life-threatening neurological emergency with the potential for wide-ranging impact on patients and caregivers. In this study, burden of disease in history SE their caregivers was assessed.Adult as well children, adolescents, adults who had experienced ≥1 event past 24 months completed an online survey. Functional, social, emotional, economic assessed. Burden measured through concept-targeted questionnaires, including US Centers Disease Control Prevention (CDC)...
Abstract For persons with epilepsy, much suffering stems from the apparent unpredictability of seizures. Historically, efforts to predict seizures have sought detect changes in brain activity seconds minutes preceding (pre-ictal period), a timeframe that limits preventative interventions. Recently, converging evidence studies using chronic intracranial electroencephalography revealed epilepsy has robust cyclical structure over hours (circadian) and days (multidien). These cycles organize...
The neurophysiological mechanisms supporting brain maturation are fundamental to attention and memory capacity across the lifespan. Human regions develop at different rates, with many developing into third fourth decades of life. Here, in this preregistered study (https://osf.io/gsru7), we analyzed intracranial EEG (iEEG) recordings from widespread a large developmental cohort. Using task-based (i.e., to-be-remembered visual stimuli) task-free (resting-state) data 101 children adults (5.93 -...
Abstract Visual search is a fundamental human behavior, providing gateway to understanding other sensory domains as well the role of in higher-order cognition. Search has been proposed include two component processes: inefficient (search) and efficient (pop-out). According extant research, these processes map onto separable neural systems located frontal parietal association cortices. In this study, we use intracranial recordings from 23 participants delineate correlates pop-out with an...