A5010258744- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Neurobiology of Language and Bilingualism
- Visual perception and processing mechanisms
- Hemispheric Asymmetry in Neuroscience
- Mental Health Research Topics
- Mind wandering and attention
- Vestibular and auditory disorders
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Reading and Literacy Development
- Complex Network Analysis Techniques
- Speech and dialogue systems
- Authorship Attribution and Profiling
- Language, Metaphor, and Cognition
- Topic Modeling
- Neuroscience and Music Perception
- Cerebral Palsy and Movement Disorders
- Advanced Chemical Sensor Technologies
- Traumatic Brain Injury Research
Northwestern University
2020-2025
Northwestern University
2023
Stanford University
2019-2021
Massachusetts General Hospital
2015-2020
Athinoula A. Martinos Center for Biomedical Imaging
2015-2020
Harvard University
2015-2020
Hammersmith Hospital
2011-2020
Imperial College London
2012-2020
Wellcome Centre for Human Neuroimaging
2014-2015
Medical Research Council
2013
Certain organizational features of brain networks present in the individual are lost when central tendencies examined group. Here we investigated detailed network organization four individuals each scanned 24 times using MRI. We discovered that distributed known as default is comprised two separate possessing adjacent regions eight or more cortical zones. A distinction between one coupled to hippocampal formation while other not. Further exploration revealed these were juxtaposed with...
There is considerable uncertainty about the function of posterior cingulate cortex (PCC). The PCC a major node within default mode network (DMN) and has high metabolic activity dense structural connectivity to widespread brain regions, which suggests it role as cortical hub. region appears be involved in internally directed thought, for example, memory recollection. However, recent nonhuman primate work provides evidence more active control cognition, through signaling an environmental...
Interactions between the Salience Network (SN) and Default Mode (DMN) are thought to be important for cognitive control. However, evidence a causal relationship networks is limited. Previously, we have reported that traumatic damage white matter tracts within SN predicts abnormal DMN function. Here investigate effect of this on network interactions accompany changing motor We initially used fMRI Stop Signal Task study response inhibition in humans. In healthy subjects, functional...
This research shows that a language network can be identified within individuals using functional connectivity. Organizational details reveal the shares common spatial motif with other association networks, including default and frontoparietal control networks. The is activated by task demands, whereas closely juxtaposed networks are not, suggesting similarly organized but differentially specialized distributed populate cortex.
Association cortex is organized into large-scale distributed networks. One such network, the default network (DN), linked to diverse forms of internal mentation, opening debate about whether shared or distinct anatomy supports multiple cognition. Using within-individual analysis procedures that preserve idiosyncratic anatomical details, we probed tasks from two domains, episodic projection and theory mind (ToM), rely on same In an initial experiment (6 subjects, each scanned 4 times), found...
Examination of large-scale distributed networks within the individual reveals details cortical network organization that are absent in group-averaged studies. One recent discovery is a transmodal network, often referred to as "default network," comprises two closely interdigitated networks, only one which coupled posterior parahippocampal cortex. Not all studies individuals have identified same and questions remain about degree separate, particularly regions hypothesized be interconnected...
Intrinsic connectivity networks (ICNs), such as the default mode, frontoparietal control, and salience networks, provide a useful large-scale description of functional architecture brain. Although ICNs are functionally specialized, information that they process needs to be integrated for coherent cognition, perception, behavior. A region capable performing this integration might expected contain traces, or "echoes," neural signals from multiple ICNs. Here, using fMRI in humans, we show...
Stable, within-individual maps of cerebellar organization reveal orderly macroscale representations the cerebral cortex with local juxtaposed zones representing distinct networks. In addition, individuals idiosyncratic organizational features.
The posteromedial cortex (PMC) is known to be a core node of the default mode network. Given its anatomical location and blood supply pattern, effects targeted disruption this part brain are largely unknown. Here, we report rare case patient (S19_137) with confirmed seizures originating within PMC. Intracranial recordings onset in right dorsal posterior cingulate cortex, adjacent marginal sulcus, likely corresponding Brodmann area 31. Upon seizures, reported reproducible sense...
A central question for cognitive neuroscience is whether there a single neural system controlling the allocation of attention. dorsal frontoparietal network brain regions often proposed as mediator top-down attention to all sensory inputs. We used functional magnetic resonance imaging in humans show that cortical networks supporting are fact modality-specific, with distinct superior fronto-parietal and fronto-temporal visuospatial non-spatial auditory respectively. In contrast, parts right...
Abstract Recent theories of cortical organisation suggest features function emerge from the spatial arrangement brain regions. For example, association cortex is located furthest systems involved in action and perception. Association also ‘interdigitated’ with adjacent regions having different patterns functional connectivity. It assumed that topographic properties, such as distance between regions, constrains their functions, however, we lack a formal description how this occurs. Here use...
The neural mechanisms supporting auditory attention are not fully understood. A dorsal frontoparietal network of brain regions is thought to mediate the spatial orienting across all sensory modalities. Key parts this network, frontal eye fields (FEF) and superior parietal lobes (SPL), contain retinotopic maps elicit saccades when stimulated. This suggests that their recruitment during might reflect crossmodal oculomotor processes; however has been confirmed experimentally. Here we...
A frontoparietal network of brain regions is often implicated in both auditory and visual information processing. Although it possible that the same set multimodal subserves modalities, there increasing evidence a differentiation sensory function within cortex. Magnetic resonance imaging (MRI) humans was used to investigate whether different showed intrinsic biases connectivity with or modalities. Structural assessed diffusion tractography functional tested using MRI. dorsal-ventral gradient...
Mind-wandering is a frequent, daily mental activity, experienced in unique ways each person. Yet neuroimaging evidence relating mind-wandering to brain for example the default mode network (DMN), has relied on population- rather than individual-based inferences owing limited within-person sampling. Here, three densely sampled individuals reported hundreds of episodes while undergoing multi-session functional magnetic resonance imaging. We found reliable associations between and DMN...
Abstract The two hemispheres of the human brain are functionally asymmetric. At network level, language exhibits left-hemisphere lateralization. While this asymmetry is widely replicated, extent to which other functional networks demonstrate lateralization remains a subject investigation. Additionally, it unknown how one may affect within individuals. We quantified for each 17 by computing relative surface area on left and right cerebral hemispheres. After examining ecological, convergent,...
Human cognition relies on two modes: a perceptually-coupled mode where mental states are driven by sensory input and perceptually-decoupled featuring self-generated content. Past work suggests that imagined supported the reinstatement of activity in cortex, but transmodal systems within canonical default network also implicated mind-wandering, recollection, imagining future. We identified brain supporting using precision fMRI. Participants different scenarios scanner, then rated their...
Reasoning about someone’s thoughts and intentions—i.e., forming a “theory of mind”—is core aspect social cognition relies on association areas the brain that have expanded disproportionately in human lineage. We recently showed these zones comprise parallel distributed networks that, despite occupying adjacent interdigitated regions, serve dissociable functions. One network is selectively recruited by cognitive processes. What circuit properties differentiate networks? Here, we show are...
Path integration, the ability to maintain a representation of location and direction on basis internal cues, is thought be important for navigation learning spatial relationships. Representations in brain, such as head cells, grid place cells limbic system, are underlie by path integration. While this idea generally consistent with lesion studies, relationship between neural activity behavior has not been studied task where animals demonstrably use integration strategy. Here we report...
Abstract Two novel and exciting avenues of neuroscientific research involve the study task‐driven dynamic reconfigurations functional connectivity networks in real‐time. While former is a well‐established field within neuroscience has received considerable attention recent years, latter remains its infancy. To date, vast majority real‐time fMRI studies have focused on single brain region at time. This due part to many challenges faced when estimating In this work, we propose methodology with...