A5073905238- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Genomics and Rare Diseases
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Neonatal and fetal brain pathology
- Metabolism and Genetic Disorders
- Genomic variations and chromosomal abnormalities
- Neurological and metabolic disorders
- Psychosomatic Disorders and Their Treatments
- Functional Brain Connectivity Studies
- Infectious Encephalopathies and Encephalitis
- Advanced MRI Techniques and Applications
- Ion channel regulation and function
- Schizophrenia research and treatment
- Electrolyte and hormonal disorders
- Fetal and Pediatric Neurological Disorders
- Mitochondrial Function and Pathology
- Glioma Diagnosis and Treatment
- Autoimmune Neurological Disorders and Treatments
- Neuroscience and Neural Engineering
- Cardiovascular Syncope and Autonomic Disorders
- Electrochemical Analysis and Applications
Beaumont Hospital
2017-2025
Botsford Hospital
2022-2025
Beaumont Hospital, Dearborn
2022-2025
Royal College of Surgeons in Ireland
2019-2024
Science Foundation Ireland
2024
Walter and Eliza Hall Institute of Medical Research
2021
The University of Adelaide
2021
Società Italiana di Reumatologia
2020
University of Luxembourg
2019
University of Tübingen
2019
Frontal lobe epilepsy (FLE) surgery is the second most common performed to treat pharmacoresistant epilepsy. Yet, little known about long-term seizure outcome following frontal lobectomy. The aim of this study investigate trends in longitudinal and identify potential prognostic indicators a cohort FLE patients investigated using modern diagnostic techniques. We reviewed 70 who underwent lobectomy between 1995 2003 (mean follow-up 4.1 +/- 3 years). Data were analysed survival analysis...
Abstract Objective Recent clinical trials have shown that cenobamate substantially improves seizure control in focal‐onset drug‐resistant epilepsy (DRE). However, little is known about cenobamate's performance highly active ( ≥ 20 seizures/month) and ultra‐refractory focal 6 failed treatments, including antiseizure medications [ASMs], surgery, vagus nerve stimulation). Here, we studied efficacy tolerability a “real‐world” severe DRE cohort. Methods We conducted single‐center retrospective...
To assess short- and long-term seizure freedom, the authors reviewed 371 patients who underwent anterior temporal lobectomy to treat pharmacoresistant epilepsy. The mean follow-up duration was 5.5 years (range 1 14.1 years). Fifty-three percent of were free at 10 years. identified multiple predictors recurrence. Results EEG performed 6 months postoperatively correlated with occurrence severity recurrence, in addition breakthrough seizures discontinuation antiepileptic drugs.
Patients undergoing epilepsy surgery for focal cortical dysplasia (FCD) guided by subdural EEG generally have a poor surgical outcome. Our objective was to identify predictors of postoperative seizure recurrence in this patient cohort.We retrospectively reviewed 48 consecutive surgeries electrode recordings between 1990 and 2004 patients with pathologic diagnosis isolated FCD. Using survival analysis, we analyzed results the noninvasive evaluation, MRI, interictal ictal patterns, extent...
The contribution of somatic variants to epilepsy has recently been demonstrated, particularly in the etiology malformations cortical development. aim this study was determine diagnostic yield genes that have previously associated with a or germline model, ascertained from resected brain tissue patients multidrug-resistant focal epilepsy.
The aim of this study was to expand the spectrum epilepsy syndromes related STX1B, encoding presynaptic protein syntaxin-1B, and establish genotype-phenotype correlations by identifying further disease-related variants.We used next-generation sequencing in framework research projects diagnostic testing. Clinical data EEGs were reviewed, including already published cases. To estimate pathogenicity variants, we established newly developed silico prediction tools.We describe 17 new variants...
Prodromal Phase of Idiopathic Generalized Epilepsy: A Register-Based Case Control Study. Gesche J, Rubboli G, Beier CP. Neurology 2024;103(8):e209921 Background and objectives: generalized epilepsy (IGE) is associated with distinct behavioral traits, symptoms frontal lobe dysfunction, psychiatric comorbidity. Whether are part the IGE endophenotype or secondary to burden chronic disease unknown. In this study, we aimed at describing sequence appearance in patients IGE. Methods: Inclusion...
This article critiques the International League Against Epilepsy (ILAE) 2015-2017 classifications of epilepsy, epileptic seizures, and status epilepticus. It points out following shortcomings ILAE classifications: (1) they mix semiological terms with epileptogenic zone terminology; (2) simple widely accepted terminology has been replaced by complex containing less information; (3) seizure evolution cannot be described in any detail; (4) four-level epilepsy classification, level two (epilepsy...
To identify the causative gene in a large unsolved family with genetic epilepsy febrile seizures plus (GEFS+), we sequenced genomes of members, and then determined contribution identified to pathogenicity epilepsies by examining sequencing data from 2,772 additional patients.We performed whole genome 3 members GEFS+ family. Subsequently, exome 1,165 patients Epi4K dataset 1,329 Australian Epi25 were interrogated. Targeted resequencing was on 278 or phenotypes. Variants validated familial...
Summary Purpose L ennox‐ G astaut syndrome ( LGS ) is a devastating childhood‐onset epilepsy syndrome. The cause unknown in 25% of cases. Little has been described about the specific clinical or electroencephalography EEG features genetic u ). E pilepsy P henome/ enome roject EPGP aims to characterize by phenotypic analysis patients with and their parents. Methods One hundred thirty‐five no known etiology parents were enrolled from 19 centers United States A ustralia. Clinical data medical...
Epilepsy and psychogenic nonepileptic seizures (PNES) can coexist may present in two forms: sequential simultaneous. In presentations, epileptic (ES) are treated PNES emerge later. Simultaneous recording of ES by video-electroencephalogram (vEEG) is less well described. We retrospectively reviewed all patients diagnosed with vEEG following standard seizure induction practices over a 21-month period. Within this cohort, we established the prevalence coexisting epilepsy using clinical...