A5086682182- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Genetics and Neurodevelopmental Disorders
- Pharmacological Effects and Toxicity Studies
- Genomics and Rare Diseases
- Metabolism and Genetic Disorders
- Neonatal and fetal brain pathology
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Photoreceptor and optogenetics research
- Psychosomatic Disorders and Their Treatments
- Cardiac electrophysiology and arrhythmias
- Neural dynamics and brain function
- Genomic variations and chromosomal abnormalities
- EEG and Brain-Computer Interfaces
- Drug Transport and Resistance Mechanisms
- Amino Acid Enzymes and Metabolism
- Mitochondrial Function and Pathology
- Retinal Development and Disorders
- Nuclear Structure and Function
- Biochemical Analysis and Sensing Techniques
- Anesthesia and Neurotoxicity Research
Washington University in St. Louis
2012-2025
Children's Hospital of Philadelphia
2024
St. Louis Children's Hospital
2006-2022
Columbia University
2017-2022
University of Miami
2022
Stanford University
2022
New York University
2022
Baylor College of Medicine
2022
Western University
2021
Children's Hospital Colorado
2020
The ketogenic diet (KD) is an effective treatment for epilepsy, but its mechanisms of action are poorly understood. We investigated the hypothesis that KD inhibits mammalian target rapamycin (mTOR) pathway signaling. expression pS6 and pAkt, markers mTOR activation, was reduced in hippocampus liver rats fed KD. In kainate model blocked hippocampal elevation occurs after status epilepticus. Because signaling has been implicated epileptogenesis, these results suggest may have anticonvulsant or...
We have examined glutamate receptor desensitization in voltage-clamped embryonic chicken spinal cord neurons and postnatal rat hippocampal maintained culture. Rapid currents that rose 0.8-3.6 msec were evoked when was ionophoresed with 0.5- to 1.0-msec pulses. With prolonged pulses or brief, repetitive pulses, glutamate-evoked decayed rapidly a manner independent of holding potential. A similar occurred following close-range pressure ejection glutamate. The rapid, desensitizing current...
The ketogenic diet and its newer variants are clinically useful in treating epilepsy. They can also have antiepileptogenic properties eventually a role other neurologic nonneurologic conditions. Despite being nearly century old, identifying the molecular underpinnings of has been challenging. However, recent studies provide experimental evidence for 4 distinct mechanisms that could contribute to antiseizure beneficial effects these diets. These include carbohydrate reduction, activation...
<b><i>Objective:</i></b> To determine the effect of ketone bodies β-hydroxybutyrate (βHB) and acetoacetate (AA) on excitatory inhibitory neurotransmission in mammalian CNS. <b><i>Background:</i></b> The ketogenic diet is presumed to be an effective anticonvulsant regimen for some children with medically intractable seizures. However, its mechanism action remains a mystery. According one hypothesis, have properties. <b><i>Methods:</i></b> authors examined βHB AA synaptic transmission rat...
Leptin is a hormone that reduces excitability in some hypothalamic neurons via leptin receptor activation of the JAK2 and PI3K intracellular signaling pathways. We hypothesized other neuronal subtypes would have anticonvulsant activity intranasal delivery be an effective route administration. tested leptin's action 2 rodent seizure models by directly injecting it into cortex or administering intranasally. Focal seizures rats were induced neocortical injections 4-aminopyridine, inhibitor...
Mood, anxiety disorders, and suicidality are more frequent in people with epilepsy than the general population. Yet, their prevalence types of mood disorders associated at time diagnosis not established. We sought to answer these questions patients newly diagnosed focal assess association suicidal ideation attempts.The data were derived from Human Epilepsy Project study. A total 347 consecutive adults aged 18-60 years enrolled within 4 months starting treatment. The identified Mini...
Sarcosine is an amino acid involved in one-carbon metabolism and a promising therapy for schizophrenia because it enhances NMDA receptor (NMDAR) function by inhibiting glycine uptake. The structural similarity between sarcosine led us to hypothesize that also agonist like glycine. We examined this possibility using whole-cell recordings from cultured embryonic mouse hippocampal neurons. found NMDAR co-agonist at the binding site. However, differed less desensitization occurred with than as...
Nicotinic acetylcholine (ACh) currents were studied in cultured postnatal rat hippocampal neurons, using whole-cell voltage-clamp techniques. In most cells, ACh produces one of two types response. One class exhibits rapid and profound desensitization is sensitive to inhibition by alpha-bungarotoxin (alpha BTXN). The second activates slowly no during prolonged agonist applications. This slow current insensitive alpha BTXN. Both the fast responses exhibit inwardly rectifying current-voltage...
We have examined glutamate receptor desensitization in voltage-clamped embryonic chicken spinal cord neurons and postnatal rat hippocampal maintained culture. Rapid currents that rose 0.8-3.6 msec were evoked when was ionophoresed with 0.5- to 1.0-msec pulses. With prolonged pulses or brief, repetitive pulses, glutamate-evoked decayed rapidly a manner independent of holding potential. A similar occurred following close-range pressure ejection glutamate. The rapid, desensitizing current...