A5063600320- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- DNA Repair Mechanisms
- Metabolism and Genetic Disorders
- Genomics and Phylogenetic Studies
- Genetics and Neurodevelopmental Disorders
- Epilepsy research and treatment
- Genomics and Rare Diseases
- RNA Research and Splicing
- Neonatal and fetal brain pathology
- Anesthesia and Pain Management
- RNA regulation and disease
- Autism Spectrum Disorder Research
- Pediatric Pain Management Techniques
- Ubiquitin and proteasome pathways
- Traumatic Brain Injury Research
- interferon and immune responses
- Functional Brain Connectivity Studies
- Cancer-related Molecular Pathways
- Genetics, Aging, and Longevity in Model Organisms
- EEG and Brain-Computer Interfaces
- Anesthesia and Neurotoxicity Research
University of North Carolina at Chapel Hill
2004-2025
University of North Carolina Hospitals
2024
Duke University
2010-2020
University of California, Irvine
2015
The Graduate Center, CUNY
2010
Hunter College
2010
UNC Lineberger Comprehensive Cancer Center
2004
Cancer Research Center
2004
Abstract Objective To investigate disparities in the utilization of genetic sequencing among children with Infantile Epileptic Spasms Syndrome (IESS), a severe early‐onset epilepsy where timely diagnosis and treatment are crucial for improving neurodevelopmental outcomes, previous studies have highlighted evaluation management IESS. Genetic has emerged as tool diagnosing unexplained epilepsies, offering precise etiological insights that can guide management. Despite guidelines recommending...
Purpose: The best possible outcomes in infantile epileptic spasms syndrome require electroclinical remission; however, determining electrographic remission is not straightforward. Although the determination of hypsarrhythmia has inadequate interrater reliability (IRR), Burden AmplitudeS and Epileptiform Discharges (BASED) score shown promise for reliable interictal assessment syndrome. Our aim was to develop a BASED training program assess IRR among learners. We hypothesized moderate or...
The mitomycin derivative 10-decarbamoyl C (DMC) more rapidly activates a p53-independent cell death pathway than (MC). We recently documented that an increased proportion of mitosene1-β-adduct formation occurs in human cells treated with DMC comparison to those MC. Here, we compare the cellular and molecular response cancer MC DMC. find increase mitosene 1-β-adduct correlates condensed nuclear morphology cytotoxicity or without p53. caused DNA damage mitochondrial genomes. Checkpoint 1...
Elongation factor Tu (EF-Tu) is responsible for the delivery of aminoacyl-tRNAs (aa-tRNA) to ribosome during protein synthesis. The primary sequence domain II EF-Tu highly conserved. However, several residues thought be important aa-tRNA binding in this are not conserved between mammalian mitochondrial and bacterial factors. One these located at position 290 (Escherichia coli numbering). Residue Gln most prokaryotic factors but as Leu (L338) This residue a loop contacting switch region I...
AbstractDuring protein biosynthesis, elongation factor Tu (EF-Tu) delivers aminoacyl-tRNA (aa-tRNA) to the A-site of ribosome. Mammalian mitochondrial EF-Tu (EF-Tumt) carries out this activity using aa-tRNAs that lack many invariant or semi-invariant residues stabilize 3-dimensional structures canonical tRNAs. The primary sequence is highly conserved. However, several involved in aa-tRNA binding are not conserved between and bacterial factors. One such residue, located at position 287...
Overgrowth-intellectual disability (OGID) syndromes are a collection of rare genetic disorders with overlapping clinical profiles. In addition to the cardinal features general overgrowth (height and/or head circumference at least two standard deviations above mean) and some degree intellectual disability, OGID often associated neurological anomalies including seizures. an effort advance research in directions that will generate meaningful treatments for people syndromes, new collaborative...