A5003586334- Epilepsy research and treatment
- Cardiovascular Syncope and Autonomic Disorders
- Cannabis and Cannabinoid Research
- Poisoning and overdose treatments
- Drug Transport and Resistance Mechanisms
- Neuroscience of respiration and sleep
- Pharmacological Effects and Toxicity Studies
- Genetics and Neurodevelopmental Disorders
- Medical and Biological Ozone Research
- Pharmaceutical studies and practices
- Sleep and Wakefulness Research
- Brain Metastases and Treatment
- Cardiac Arrhythmias and Treatments
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Educational Outcomes and Influences
- Hemoglobinopathies and Related Disorders
- Polyomavirus and related diseases
- Complementary and Alternative Medicine Studies
- Meningioma and schwannoma management
- Pneumonia and Respiratory Infections
- Psychosomatic Disorders and Their Treatments
- Education in Rural Contexts
- Antibiotic Use and Resistance
- Tuberous Sclerosis Complex Research
Massachusetts General Hospital
2012-2022
Harvard University Press
2009
Summary Objective Under an expanded access investigational new drug ( IND ) trial, cannabidiol CBD is being studied as a possible adjuvant treatment of refractory epilepsy in children. Of the 25 subjects 13 were treated with clobazam CLB ). Because and are both metabolized cytochrome P450 CYP pathway, we predicted drug–drug interaction, which evaluate this article. Methods Thirteen concomitantly taking under 119876 included study. Demographic information was collected for each subject...
Tuberous sclerosis complex (TSC) is an autosomal-dominant genetic disorder with highly variable expression. The most common neurologic manifestation of TSC epilepsy, which affects approximately 85% patients, 63% whom develop treatment-resistant epilepsy. Herein, we evaluate the efficacy, safety, and tolerability cannabidiol (CBD), a nonpsychoactive compound derived from marijuana plant, as adjunct to current antiepileptic drugs in patients refractory seizures setting TSC.Eighteen 56 who have...
Angelman syndrome (AS) commonly presents with epilepsy (>80%). The goal of this study was to examine the natural history and various treatments in AS a large population.A detailed electronic survey containing comprehensive questions regarding conducted through Syndrome Foundation.There were responses from 461 family members individuals AS, whom 86% had (60% multiple seizure types), most common being atonic, generalized tonic-clonic, absence, complex partial. Partial-onset seizures only...
Summary Purpose: Disrupted sleep patterns in children with epilepsy and their parents are commonly described clinically. A number of studies have shown increased frequency disorders among pediatric patients; however, few characterized the association between parental quality household sleeping arrangements. The purpose this study was to explore effect on child sleep, fatigue, parent‐child arrangements, including room sharing cosleeping. Methods: Parents 2 10 years age without completed...
Abstract Objective Cannabidiol (CBD) has been shown to reduce seizures among patients with refractory epilepsies of various etiologies in recent clinical trials and an expanded access program (EAP). Most studies report efficacy over short time periods (<1 year), little published on longer term efficacy. Here, we investigate the CBD for a treatment period up 60 months (median = 45.5 months). Methods We conducted retrospective review patient‐reported seizure logs medical records 54 subjects...
Abstract Aims . To characterize the clinical phenotype of Sunflower syndrome. syndrome is a rare photosensitive epilepsy characterized by highly stereotyped seizures, photosensitivity, and heliotropism. Methods We retrospectively reviewed medical records patients seen in Massachusetts General Hospital for Children (MGHfC) pediatric program with history Results Twenty‐four were identified; 18 female. At time initial MGHfC evaluation, patients’ ages ranged from 6.4 to 25 years, median age 11.5...
To determine the efficacy of fenfluramine on seizure frequency in patients with Sunflower syndrome. Secondary endpoints were changes electroencephalogram (EEG) characteristics, cognitive functioning, executive and quality life.In this open-label study, underwent a 4-week baseline period, followed by 3 months treatment. An oral solution was administered twice daily for months. The dose titrated up to maximum 0.7mg/kg/day or 26mg/day. Cardiac safety monitored transthoracic echocardiogram...
Abstract Aim This study reports on the long‐term results for an initial cohort of patients with Sunflower syndrome who enrolled in open‐label low‐dose fenfluramine as well short‐term a second cohort. Method We conducted single‐center, at Massachusetts General Hospital. analyzed effect handwaving seizure frequency monthly intervals during 4‐month core period patient cohort, and we evaluated (>2 years) Results Eight 10 from provided analyzable data. These experienced 33% median reduction...
To evaluate the efficacy and tolerability of adjunctive fenfluramine in treating patients with sunflower syndrome.
To determine the safety, tolerability, and efficacy of rufinamide in treating refractory epilepsy a largely pediatric population. A retrospective chart review was conducted all patients prescribed from December 2008 to July 2010 Pediatric Epilepsy Program at Massachusetts General Hospital for Children. Eighty-eight on with sufficient data analysis were included study. Eight (9.1%) had >90% seizure reduction, 40 (45.5%) 50-90% 19 (21.6%) <50% 21 (23.9%) no change frequency. Generally mild...

 Se analizan los resultados de 78 pacientes irradiados con técnica radiocirugía estereotáxica a lesiones tumorales y vasculares alojadas en el cerebro, Centro Médico Deán Funes, Córdoba, Argentina. Dichos tratamientos se realizaron desde agosto 2007 hasta diciembre del 2013. El tratamiento consistió dar una dosis única radioterapia 4 cm diámetro, localización al blanco terapéutico las 3 dimensiones espacio. La planificación realizó un programa distribución última...