A5073974217- Radiation Dose and Imaging
- Radiology practices and education
- Advanced Neuroimaging Techniques and Applications
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Advanced MRI Techniques and Applications
- Artificial Intelligence in Healthcare and Education
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Cardiac Arrest and Resuscitation
- Innovations in Medical Education
- Advanced X-ray and CT Imaging
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Autism Spectrum Disorder Research
- Clinical Reasoning and Diagnostic Skills
- Genetics and Neurodevelopmental Disorders
- Congenital heart defects research
- Blood Coagulation and Thrombosis Mechanisms
- Neuroblastoma Research and Treatments
- Chromatin Remodeling and Cancer
- Acute Ischemic Stroke Management
- Ultrasound in Clinical Applications
- Patient-Provider Communication in Healthcare
- Neurological Complications and Syndromes
Children's Hospital of Philadelphia
2020-2025
University of Pennsylvania
2021-2025
Boston Children's Hospital
2020-2025
California University of Pennsylvania
2023
Philadelphia University
2021-2022
Massachusetts General Hospital
2017-2020
Harvard University
2017-2020
Albert Einstein College of Medicine
2010-2017
Montefiore Medical Center
2015-2017
Hypoxic ischemic encephalopathy (HIE) is a brain injury that occurs in 1 ~ 5/1000 term neonates. Accurate identification and segmentation of HIE-related lesions neonatal magnetic resonance images (MRIs) the first step toward identifying high-risk patients, understanding neurological symptoms, evaluating treatment effects, predicting outcomes. We release public dataset containing diffusion MRI expert annotation from 133 patients diagnosed with HIE. are often diffuse (i.e., multi-focal), small...
Autism spectrum disorder (ASD) is associated with significant clinical, neuroanatomical, and genetic heterogeneity that limits precision diagnostics treatment.
INTRODUCTION: Minimally invasive procedures such as MRI-guided LiTT are increasingly being utilized in pediatric epilepsy patients; however, their clinical efficacy has been limited by challenges precisely localizing epileptogenic tissues. A precise and accurate means to highlight tissues noninvasively will augment the utility of LiTT. Previous studies have suggested that an apparent diffusion coefficient (ADC) map may microstructural abnormalities commonly seen temporal lobe provide a...
ABSTRACT Hypoxic ischemic encephalopathy (HIE) is a brain injury that occurs in 1 ∼5 / 1000 term neonates. Accurate identification and segmentation of HIE-related lesions neonatal magnetic resonance images (MRIs) the first step toward predicting prognosis, identifying high-risk patients, evaluating treatment effects. It will lead to more accurate estimation better understanding neurological symptoms, timely prediction response therapy. We release public dataset containing diffusion MRI...
OBJECTIVE Severe traumatic brain injury (TBI) is a leading cause of disability and death in the pediatric population. While intracranial pressure (ICP) monitoring gold standard acute neurocritical care following severe TBI, tissue oxygen tension (PbtO 2 ) may also help limit secondary improve outcomes. The authors hypothesized that patients with TBI ICP + PbtO treatment would have better outcomes than those who underwent ICP-only treatment. METHODS Patients ≤ 18 years age received ± at...
To demonstrate that a novel noninvasive index of intracranial pressure (ICP) derived from diffuse optics-based techniques is associated with hypertension.We compared and invasive ICP measurements in infants hydrocephalus. Infants born term preterm were eligible for inclusion if clinically determined to require cerebrospinal fluid (CSF) diversion. Ventricular size was assessed preoperatively via ultrasound measurement the fronto-occipital (FOR) frontotemporal (FTHR) horn ratios. Invasive...
Background A framework for understanding rapid diffusion changes from 0 to 6 years of age is important in the detection neurodevelopmental disorders. Purpose To quantify patterns normal apparent coefficient (ADC) development age. Materials and Methods Previously constructed age-specific ADC atlases 201 healthy full-term children (108 male; range, 0–6 years) with MRI scans acquired 2006 2013 at one large academic hospital were analyzed four patterns: trajectory, rate change, maturation,...
Abstract Human infancy is marked by fastest postnatal brain structural changes. It also coincides with the onset of many neurodevelopmental disorders. Atlas‐based automated structure labeling has been widely used for analyzing various neuroimaging data. However, relatively large and nonlinear neuroanatomical differences between infant adult brains can lead to significant offsets labeled structures in when atlas used. Age‐specific 1‐ 2‐year‐old atlases covering all major gray white matter (GM...
Objective: In this proof-of-concept study, we aimed to develop deep-learning-based classifiers identify rib fractures on frontal chest radiographs in children under 2 years of age. Methods: This retrospective study included 1311 (radiographs with fractures, n = 653) from 1231 unique patients (median age: 4 m). Patients more than one radiograph were only the training set. A binary classification was performed presence or absence using transfer learning and Resnet-50 DenseNet-121...
Introduction: Pediatric severe traumatic brain injury (TBI) is one of the leading causes disability and death. One classic pathoanatomic lesions following pediatric TBI diffuse (multifocal) axonal (DAI). In this single institution study, our overarching goal was to describe clinical characteristics long-term outcome trajectory patients with DAI. Methods: (<18 years age) who had DAI were retrospectively reviewed. We evaluated effect age, sex, Glasgow Coma Scale (GCS) score, early fever...
Abstract Objective SCN2A encodes the voltage‐gated sodium (Na+) channel α subunit Na V 1.2, which is important for generation and forward back propagation of action potentials in neurons. Genetic variants are associated with a spectrum neurodevelopmental disorders. However, mechanisms whereby variation leads to disease remains incompletely understood, full ‐related disorders may not be fully delineated. Methods Here, we identified seven de novo heterozygous eight individuals developmental...
Understanding the brain differences present at earliest possible diagnostic age for autism spectrum disorder (ASD) is crucial delineating underlying neuropathology of disorder. However, knowledge structural network changes in early important developmental period between 2 and 7 years limited children with ASD. In this study, we aimed to fill gap by characterizing age-related ASD from age, identify sensitive network-based imaging biomarkers that are significantly correlated symptom severity....