A5073903526- Cerebral Palsy and Movement Disorders
- Infant Development and Preterm Care
- Stroke Rehabilitation and Recovery
- Family and Disability Support Research
- Botulinum Toxin and Related Neurological Disorders
- Genetics and Neurodevelopmental Disorders
- Muscle activation and electromyography studies
- Traumatic Brain Injury Research
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Spinal Cord Injury Research
- Genomics and Rare Diseases
- Cerebrospinal fluid and hydrocephalus
- Connexins and lens biology
- Nerve Injury and Rehabilitation
- Musculoskeletal pain and rehabilitation
- Genomic variations and chromosomal abnormalities
- Metabolism and Genetic Disorders
- Spanish History and Politics
- Injury Epidemiology and Prevention
- RNA regulation and disease
- Historical and Religious Studies of Rome
- Balance, Gait, and Falls Prevention
- Historical Art and Culture Studies
- interferon and immune responses
Children's Hospital of Philadelphia
2012-2025
Pierce College
2024
American Physical Therapy Association
2024
Philadelphia University
2023
University of Pennsylvania
2023
Edge Hill University
2019
Widener University
2006-2018
Shriners Hospitals for Children
2012
Shriners Hospitals for Children - Philadelphia
2003-2012
Temple University
2009-2012
An infant's risk of developing neuromotor impairment is primarily assessed through visual examination by specialized clinicians. Therefore, many infants at for go undetected, particularly in under-resourced environments. There thus a need to develop automated, clinical assessments based on quantitative measures from widely-available sources, such as videos recorded mobile device. Here, we automatically extract body poses and movement kinematics the at-risk (N = 19). For each infant,...
Disease-causing variants in STXBP1 are among the most common genetic causes of neurodevelopmental disorders. However, phenotypic spectrum STXBP1-related disorders is wide and clear correlations between variant type clinical features have not been observed so far. Here, we harmonized data across 534 individuals with analysed 19 973 derived terms, including phenotypes 253 previously unreported scientific literature. The overall landscape characterized by abnormalities 95% seizures 89%...
Large tracts of lowlands have been drained to expand extensive agriculture into areas that were historically categorized as wasteland. This expansion in necessarily coincided with changes ecosystem structure, biodiversity, and nutrient cycling. These impacted not only the landscapes which they occurred, but also larger water bodies receiving runoff from land. New approaches must append current efforts toward land conservation restoration, continuing impacts waters is an issue major...
Abstract STXBP1-related disorders are among the most common genetic epilepsies and neurodevelopmental disorders. However, longitudinal epilepsy course developmental end points, have not yet been described in detail, which is a critical prerequisite for clinical trial readiness. Here, we assessed 1281 cumulative patient-years of seizure histories 162 individuals with established natural history framework. characterized by dynamic pattern seizures first year life high variability trajectories...
The drawings (plates XII–XVIII) which accompany this article were prepared during my tenure of the Rome Scholarship at British School Rome; and, while they may be sufficient for architect or layman to obtain a better realisation original state monument, it has been thought that an attempt should made discuss, in greater detail than is possible present on drawings, various considerations and data upon essay restoration ancient building must necessarily based. To end following prepared. I wish...
To compare the effectiveness of errorless learning versus trial and error for teaching activities daily living to patients with acute stroke or without explicit memory impairments.Randomized crossover.Rehabilitation hospital.Thirty-three adult subjects following an stroke.Subjects were taught prepare a wheelchair transfer put on sock sock-donner. Tasks using learning. Explicit was assessed Neurobehavioral Cognitive Status Exam.Days until subject able demonstrate retention task, success...
The objective of this study was to examine the effectiveness a program traditional outpatient neurological rehabilitation that included home forced use. In total, 17 patients with chronic stroke and 1 patient subacute (mean time poststroke = 27.6 months) completed an individualized consisting seven 2-hour treatment sessions composed hour occupational therapy physical therapy. Therapy were over 2- 3-week period instruction on use restraining mitt at during functional activities. Wolf Motor...
The purpose of this brief report was to compare the immediate effects surface functional electrical stimulation (S-FES) and percutaneous (P-FES) tibialis anterior applied during gait in a child with hemiplegic cerebral palsy. A three-dimensional analysis conducted while an 11-yr-old girl right hemiplegia walked S-FES, P-FES, no stimulation. results indicated that both P-FES S-FES increased dorsiflexion at initial contact, peak swing, mean swing compared walking without increase greater as...
Traumatic brain injury is a leading cause of death in bicycle crashes. The factors associated with helmet use young children diverse ethnic and socioeconomic backgrounds have not been studied. purpose this study was to identify barriers an urban elementary school.Qualitative content analysis semistructured interviews, observational field notes, artifacts.Urban school.Seventeen students whose age ranged from 5 7 years background identified as African American (14) or Caucasian (3).Children...
Cerebral palsy (CP) is the most common cause of physical disability in children. The best opportunity to maximize lifelong independence early motor development when there potential for neuroplastic change, but how optimize ability during this narrow window remains unknown. We have systematically developed and pilot-tested a novel intervention that incorporates overlapping principles neurorehabilitation infant learning context promotes upright mobility skill postural control development....
The feasibility of percutaneous intramuscular functional electrical stimulation (P-FES) in children with cerebral palsy (CP) for immediate improvement ankle kinematics during gait has not previously been reported. Eight CP (six diplegia, two hemiplegia; mean age 9 years 1 month [SD y 4 mo; range 7 11 mo to 10 mo]) had electrodes implanted into the gastrocnemius (GA) and tibialis anterior (TA) muscles their involved limbs. Stimulation was provided appropriate phases cycle three conditions (GA...
Aims Typical infant movement is characterized by a high degree of motor exploration, error, and variability. However, children with cerebral palsy (CP) often cannot create these experiences due to their neuromotor impairments. The purpose this case study describe 6-month course physical therapy (PT) incorporating principles learning using dynamic weight support (DWS) in child CP.Methods was 27-month-old girl diplegic CP who functioned at Gross Motor Function Classification System Level IV....
Cerebral palsy (CP) is the most common cause of motor disability in children. A concept to consider order meet needs children with CP and their families family empowerment. Family empowerment can be defined as process by which acquire skills, knowledge resources allow them gain control improve quality lives. The relationship between gross function may important because vary so widely ability perform affect family's levels purpose this research was investigate Empowerment Scale (FES) Gross...
TUBB4A pathogenic variants are associated with a spectrum of neurologic impairments including movement disorders and leukodystrophy. With the development targeted therapies, there is an urgent unmet need for validated tools to measure mobility impairment. Our aim explore gross motor function in pediatric-onset TUBB4A-related leukodystrophy cohort existing outcome tools. Gross Motor Function Measure-88 (GMFM-88), Classification System (GMFCS-ER), Classification-Metachromatic Leukodystrophy...
Background: Aicardi-Goutières syndrome (AGS) is a rare genetic disorder characterized by spectrum of motor abilities. While the severity score favors severely impacted individuals, there an unmet need to define tools measuring function across as potential outcome assessments for future clinical trials. Methods: Gross Motor Function Measure-88 (GMFM-88) and AGS Severity Scale were administered in individuals affected (n = 71). We performance variability genotype. Derived versions GMFM-88,...
To compare the effect of iMOVE (Intensive Mobility training with Variability and Error) therapy dose-matched conventional on gross motor development secondary outcomes in young children cerebral palsy.