A5069163089- Neonatal Respiratory Health Research
- Migration, Health and Trauma
- Child and Adolescent Health
- interferon and immune responses
- Neuroscience of respiration and sleep
- Herpesvirus Infections and Treatments
- Infant Development and Preterm Care
- Virology and Viral Diseases
- Global Maternal and Child Health
- Maternal and Perinatal Health Interventions
- Lysosomal Storage Disorders Research
- SARS-CoV-2 and COVID-19 Research
- Dermatological diseases and infestations
- Cerebral Palsy and Movement Disorders
- Emergency and Acute Care Studies
- Pregnancy and preeclampsia studies
- COVID-19 Pandemic Impacts
- Maternal and fetal healthcare
- Gastric Cancer Management and Outcomes
- Urticaria and Related Conditions
- Neonatal Health and Biochemistry
- Genetics and Neurodevelopmental Disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Gallbladder and Bile Duct Disorders
- Peroxisome Proliferator-Activated Receptors
University of Pennsylvania
2023-2025
Children's Hospital of Philadelphia
2023-2024
Rutgers, The State University of New Jersey
2021-2024
National Center for Advancing Translational Sciences
2022
Weatherford College
2022
Immigrant birthing people have lower rates of preterm birth compared with their US-born counterparts. This advantage and associated racial ethnic disparities across the gestational age spectrum not been examined nationally.
OBJECTIVE: To evaluate whether there are individual- and population-level associations between chronic hypertension pregnancy complications, to assess differences across seven racial–ethnic groups. METHODS: This population-based study used linked vital statistics hospitalization discharge data from all live stillbirths in California (2008–2018), Michigan (2008–2020), Oregon Pennsylvania (2008–2014), South Carolina (2008–2020). We multivariable log-binomial regression models estimate risk...
BACKGROUND US infant mortality rate (IMR), defined as deaths under 1 year of age per 1000 live births, is higher among rural infants than their urban counterparts. Although much known about rural-urban inequities in IMR, disaggregated data by preterm birth status are lacking. OBJECTIVES (1) Evaluate the differences IMR born earlier 37 weeks’ gestation. (2) Determine prevalence and predictors race ethnicity or residence. METHODS Linked national death certificate from 2005 to 2014 were used....
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome-coronavirus-2, has claimed 5,587,549 lives worldwide as of January 20, 2022. Fortunately, large-scale vaccination can mitigate impact COVID-19 making disease milder and less common. Although 75.2% United States population received at least 1 dose a vaccines thus far, concerns regarding vaccine side effects have contributed to hesitancy. Furthermore, nearly 50% adults in are concerned...
TUBB4A pathogenic variants are associated with a spectrum of neurologic impairments including movement disorders and leukodystrophy. With the development targeted therapies, there is an urgent unmet need for validated tools to measure mobility impairment. Our aim explore gross motor function in pediatric-onset TUBB4A-related leukodystrophy cohort existing outcome tools. Gross Motor Function Measure-88 (GMFM-88), Classification System (GMFCS-ER), Classification-Metachromatic Leukodystrophy...
Background: Aicardi-Goutières syndrome (AGS) is a rare genetic disorder characterized by spectrum of motor abilities. While the severity score favors severely impacted individuals, there an unmet need to define tools measuring function across as potential outcome assessments for future clinical trials. Methods: Gross Motor Function Measure-88 (GMFM-88) and AGS Severity Scale were administered in individuals affected (n = 71). We performance variability genotype. Derived versions GMFM-88,...
Measures of perinatal care quality and outcomes often focus on either the birth parent or infant. We used linked vital statistics hospital discharge data to describe a dyadic measure (including both infant) for during hospitalization. In this five-state cohort 2010–18 births, 21.6 percent parent–infant dyads experienced at least one complication, 9.6 severe complication. Severe infant complications were eight times more prevalent than complications. Among parents with co-occurrence...
This retrospective chart review examined children with documented Lyme disease serology in New Jersey aged <21 years presenting facial nerve palsy. The presence of symptoms including tick bite, fever, headache, and arthritis was recorded. Data were categorized based on demographic factors, multivariate regression employed. We enrolled 122 children, 54% female (mean age 11.4 ± 5.1 years); 22.1% had disease. Fever a significant predictor (
Aicardi-Goutières syndrome is a genetic inflammatory disorder resulting in dispersed neurologic dysfunction. Despite recognition of overall motor impairment, fine and visual skills are undercharacterized. We hypothesize that there spectrum the population as captured by standard outcome measure, Peabody Developmental Motor Scales (PDMS-2), which will be proportional to disease severity. In cohort 74 subjects, Scales–2 grasping visual-motor integration subtests were administered concurrently...
Aicardi Goutières syndrome (AGS) is type I interferonopathy characterized by severe neurologic impairment. Although many children with AGS demonstrate motor and expressive language deficits, the magnitude of receptive impairment uncharacterized. We sought to characterize cognitive function in AGS-affected using assessment tools reduced dependence on abilities compare testing outcomes overall severity parental adaptive behavior.
Abstract Objective To examine the association of admission NICU strain with neonatal mortality and morbidity. Study Design 2008-2021 South Carolina cohort using linked vital statistics discharge data 22-44 weeks GA infants, born at hospitals ≥ level 2 unit ≥5 births infants <34 GA/year. The exposure was tertiles strain, defined as sum <44 a congenital anomaly plus all <33 midnight on day birth. We used Poisson generalized linear mixed models to primary outcome composite term preterm...
Screening colonoscopies are recommended for the detection and prevention of colon cancer. Liquid colonoscopy preparations may be poorly tolerated. We evaluated adequacy tolerability a novel low-cost preparation consisting magnesium citrate capsules bisacodyl (MCCB).This is single-center, assessor-blinded, randomized controlled trial 51 patients undergoing screening colonoscopies, who received bowel either 4 liters GoLYTELY (Braintree Laboratories, Inc., Braintree, MA) or MCCB. The primary...