A5076354649- Neonatal and Maternal Infections
- Antibiotic Resistance in Bacteria
- Sepsis Diagnosis and Treatment
- Preterm Birth and Chorioamnionitis
- Pneumonia and Respiratory Infections
- Maternal and Perinatal Health Interventions
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Vibrio bacteria research studies
- Streptococcal Infections and Treatments
- Neonatal Health and Biochemistry
- Maternal Mental Health During Pregnancy and Postpartum
- Viral gastroenteritis research and epidemiology
- Family and Patient Care in Intensive Care Units
- Palliative Care and End-of-Life Issues
- Diabetic Foot Ulcer Assessment and Management
- Insects and Parasite Interactions
- Hepatitis Viruses Studies and Epidemiology
- Neonatal skin health care
- Neonatal and fetal brain pathology
- Nosocomial Infections in ICU
- Respiratory viral infections research
- Pharmaceutical and Antibiotic Environmental Impacts
- Health disparities and outcomes
- Biosensors and Analytical Detection
Children's Hospital of Philadelphia
2021-2024
University of Pennsylvania
2023-2024
Institute of Health Economics
2023
Children's Healthcare of Atlanta
2023
Emory University
2023
Tufts Medical Center
2021
Brigham and Women's Hospital
2021
The University of Texas Southwestern Medical Center
2021
Importance Appreciation for the effects of neighborhood conditions and community factors on perinatal health is increasing. However, community-level indices specific to maternal associations with preterm birth (PTB) have not been assessed. Objective To examine association Maternal Vulnerability Index (MVI), a novel county-level index designed quantify vulnerability adverse outcomes, PTB. Design, Setting, Participants This retrospective cohort study used US Vital Statistics data from January...
Abstract Introduction Infections due to extended spectrum beta-lactamase producing organisms (ESBL) have emerged as the leading cause of sepsis among hospitalized neonates in Botswana and much sub-Saharan Africa south Asia. Yet, ESBL reservoirs transmission dynamics within neonatal intensive care unit (NICU) environment are not well-understood. This study aimed assess efficiency feasibility a chromogenic-culture-media-based environmental sampling approach characterize bioburden NICU. Methods...
ABSTRACT Sepsis is the leading postnatal cause of neonatal mortality worldwide. Globally Klebsiella pneumoniae sepsis in hospitalized neonates. This study reports development and evaluation ELISA for anti- IgG using dried blood spot samples evaluates association (anti-Kleb IgG) antibodies maternal risk sepsis. Neonates their mothers were enrolled at 0-96 hours life unit a tertiary referral hospital Gaborone, Botswana followed until death or discharge to assess episodes culture-confirmed with...
Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major cause of bloodstream infection among hospitalized patients in low- and middle-income countries (LMICs). CRAB infections can be difficult to treat are devastating neonates (~30% mortality). outbreaks hypothesized arise from reservoirs the hospital environment, but outbreak investigations LMICs seldom incorporate whole-genome sequencing (WGS). Methods: WGS (Illumina NextSeq) was performed at National...
Background: Multidrug-resistant Gram-negative bacteria are a major cause of sepsis among hospitalized neonates globally. Aqueous chlorhexidine gluconate (CHG) skin antisepsis has been shown to be safe for use in infants; however, its sustained effectiveness preventing pathogen colonization, bloodstream infection (BSI), and mortality is unclear. Methods: We conducted period prevalence survey, with 26 sampling events over 12 months (18 October 2022 – 31 2023) at 33-bed neonatal unit tertiary...
Sepsis is the leading postnatal cause of neonatal mortality worldwide. Globally Klebsiella pneumoniae sepsis in hospitalized neonates. This study reports development and evaluation an ELISA for anti- IgG using dried blood spot (DBS) samples evaluates association (anti-Kleb IgG) antibodies maternal with risk sepsis. Neonates their mothers were enrolled at 0–96 hours life unit a tertiary referral hospital Gaborone, Botswana followed until death or discharge to assess episodes culture-confirmed...
BACKGROUND AND OBJECTIVES Many neonatal intensive care units (NICUs) do not give rotavirus vaccines to inpatients due a theoretical risk of horizontal transmission vaccine strains. We aimed determine incidence and clinical significance vaccine-strain unvaccinated infants in NICU that routinely administers pentavalent (RV5). METHODS This prospective cohort study included all patients admitted 100-bed for 1 year. Stool specimens were collected weekly; real-time quantitative...
Abstract A significant proportion of newborn infants need facemask assisted resuscitation to start breathing successfully after birth. Positive pressure ventilation (PPV) is the most important intervention yet often impeded by leak. conformable, tacky silica gel that can be attached mask as a cushion developed through reverse engineering. Finite element simulation reveals forms completely sealed interface while alone without has many potential leak sites. Since material 20 times softer than...
Abstract Carbapenem-resistant Acinetobacter baumannii (CRAb) has emerged as a major and often fatal cause of bloodstream infections among hospitalized patients in low- middle-income countries (LMICs). CRAb outbreaks are hypothesized to arise from reservoirs the hospital environment, but outbreak investigations LMICs seldom able incorporate whole genome sequencing (WGS) due resource limitations. We performed WGS at National Institute for Communicable Diseases (Johannesburg, South Africa) on...
In low- and middle-income countries, where antimicrobial access may be erratic neonatal sepsis pathogens are frequently multidrug-resistant, empiric antibiotic prescribing practices diverge from the World Health Organization (WHO) guidelines. This study examined for at a tertiary referral hospital unit in Gaborone, Botswana, using data prospective cohort of 467 neonates. We reviewed prescriptions first episode suspected sepsis, categorized as early-onset (EOS, days 0-3) or late-onset (LOS,...
(Abstracted from JAMA Network Open 2023;6(5):e2315306) In the United States, approximately 1 in 10 births are considered preterm, or born at <37 weeks of gestation. Historically, studies on preterm birth (PTB) have focused maternal characteristics. However, an appreciation for impact community factors, such as poverty, air pollution, and other measures neighborhood quality, PTB is growing.
Abstract Introduction: Infections due to extended spectrum beta-lactamase producing Enterobacterales (ESBL-PE) have emerged as the leading cause of sepsis among hospitalized neonates in Botswana and much sub-Saharan Africa south Asia. Yet, ESBL-PE reservoirs transmission dynamics within neonatal intensive care unit (NICU) environment are not well-understood. This study aimed assess efficiency feasibility a chromogenic-culture-media-based environmental sampling approach characterize bioburden...