A5103132643- Epilepsy research and treatment
- Neonatal and fetal brain pathology
- Pharmacological Effects and Toxicity Studies
- Genomics and Rare Diseases
- Glioma Diagnosis and Treatment
- Vagus Nerve Stimulation Research
- Acute Ischemic Stroke Management
- EEG and Brain-Computer Interfaces
- Cerebral Venous Sinus Thrombosis
- Nerve Injury and Rehabilitation
- RNA regulation and disease
- Neurological disorders and treatments
- Neuroscience and Neural Engineering
- Neurological Complications and Syndromes
- Mitochondrial Function and Pathology
- Functional Brain Connectivity Studies
- Peripheral Nerve Disorders
- Orthopedic Surgery and Rehabilitation
- Cerebrospinal fluid and hydrocephalus
University of Pennsylvania
2023-2025
California University of Pennsylvania
2023
The increasingly widespread use of stereo-EEG in the pre-surgical evaluation has led to greater recognition insula as both a source and surgical target for drug-resistant epilepsy. Clinicians have long appreciated challenges diagnosing treating seizures arising from insula. Insular-onset present with wide variety semiologies due its dense complex integration other brain structures, resulting insula's reputation "great mimicker." Surgical access is guarded by overlying frontal, temporal,...
Hemispherotomy represents definitive treatment for drug-resistant epilepsy with unilateral hemispheric onset. Traditional approaches involve a large incision and open craniotomy, associated risks of blood loss, infection, poor wound healing, pain, cosmetic concerns, long hospital stays. The authors describe minimally invasive hemispherotomy technique through single burr hole overlying the Sylvian fissure. A case series first cohort patients to undergo this procedure is detailed provide an...
ABSTRACT Background Hemispherectomy and hemispherotomy represent well‐established treatments for drug‐resistant hemispheric epilepsy. An alternative endovascular procedure has been explored cases with challenging surgical anatomy, which seeks to achieve the clinical effect of hemispherectomy via embolization major cerebral arteries subsequent infarction. Neither safety nor effectiveness this established. Patient Description A 4‐month‐old girl a history focal epilepsy due left‐sided...
In this study, the authors describe their 10-year single-institution experience with single-step complete corpus callosotomy (CCC) for seizure management in pediatric and adult patients catastrophic, medically refractory, nonlocalizing epilepsy at Advent Health Orlando.The conducted a retrospective observational study of aged 6 months to 49 years who underwent clinically indicated CCC drug-resistant Orlando between July 2011 2021. Follow-up ranged from 12 10 years.Of 101 (57% whom were male)...
Trans-sylvian peri-insular hemispherotomy represents a functional hemispherectomy with minimal brain removal used for treatment of refractory hemispheric epilepsy. 1 Exposure this procedure is achieved by craniotomy. Refinement in the technique, including trends toward minimizing cortical resection, has contributed to substantial drop complication rates. 2 We present refinement allowing complete disconnection through single burr hole. In instance, technique was applied case 4-year-old girl...
Abstract Polymorphous low-grade neuroepithelial tumors of the young (PLNTY) represent a rare pediatric-type tumor that most commonly presents as medically refractory epilepsy. PLNTY has only recently been recognized distinct clinical entity, having first described in 2016 and added to World Health Organization classification CNS 2021. Molecular studies have determined is uniformly driven by aberrant MAPK pathway activation, with carrying either BRAF V600E mutation or activating FGFR2 FGFR3...