A5025103354- Glioma Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Brain Metastases and Treatment
- RNA modifications and cancer
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- CNS Lymphoma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Allergic Rhinitis and Sensitization
- RNA Research and Splicing
- Chromatin Remodeling and Cancer
- Genetic Associations and Epidemiology
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- CAR-T cell therapy research
- Lung Cancer Treatments and Mutations
- Radiopharmaceutical Chemistry and Applications
- Asthma and respiratory diseases
- Biosimilars and Bioanalytical Methods
University of Southern California
2013-2023
Massachusetts General Hospital
2023
Menlo School
2022
Zymeworks (Canada)
2019
George Washington University
2019
University of Macau
2019
Aduro BioTech (United States)
2018
University of Alberta
2017
Keck Hospital of USC
2017
LAC+USC Medical Center
2016-2017
A multicenter phase II study was conducted to assess the efficacy of rituximab, methotrexate, procarbazine, and vincristine (R-MPV) followed by consolidation reduced-dose whole-brain radiotherapy (rdWBRT) cytarabine in primary CNS lymphoma.Patients received induction chemotherapy with R-MPV (five seven cycles); those achieving a complete response (CR) rdWBRT (23.4 Gy), otherwise, standard WBRT offered (45 Gy). Consolidation given after radiotherapy. The end point 2-year progression-free...
Our goals were to evaluate the safety of adding rituximab methotrexate (MTX)-based chemotherapy for primary CNS lymphoma, determine whether additional cycles induction improve complete response (CR) rate, and examine effectiveness toxicity reduced-dose whole-brain radiotherapy (WBRT) after CR.Thirty patients (17 women; median age, 57 years; Karnofsky performance score, 70) treated with five seven (rituximab, MTX, procarbazine, vincristine [R-MPV]) as follows: day 1, 500 mg/m2; 2, MTX 3.5...
Recent evidence suggests that many endogenous circular RNAs (circRNAs) may play roles in biological processes. However, the expression patterns and functions of circRNAs human diseases are not well understood. Computationally identifying from total RNA-seq data is a primary step studying their pattern roles. In this work, we have developed computational pipeline named UROBORUS to detect data. By applying 46 gliomas normal brain samples, detected thousands supported by at least two read...
Gliomas are the most common brain tumor, with several histological subtypes of various malignancy grade. The genetic contribution to familial glioma is not well understood. Using whole exome sequencing 90 individuals from 55 families, we identified two families mutations in POT1 (p.G95C, p.E450X), a member telomere shelterin complex, shared by both affected each family and predicted impact DNA binding TPP1 binding, respectively. Validation separate cohort 264 246 an additional mutation...
Convection-enhanced delivery of chemotherapeutics for the treatment malignant glioma is a technique that delivers drugs directly into tumor and surrounding interstitium through continuous, low-grade positive-pressure infusion. This allows high local concentrations drug while overcoming limitations imposed by toxicity blood-brain barrier in systemic therapies prevent use many potentially effective drugs.To examine safety profile conventional chemotherapeutic agent, topotecan, via...
Abstract Background: Several previous studies have found inverse associations between glioma susceptibility and a history of allergies or other atopic conditions. Some evidence indicates that respiratory are likely to be particularly relevant with regard risk. Using data from the Glioma International Case-Control Study (GICC), we examined effects conditions on Methods: The GICC contains detailed information for 4,533 cases 4,171 controls, recruited 14 study sites across five countries....
Autopsy studies reveal that most primary CNS lymphomas (PCNSL) extensively infiltrate the brain. To date, there has been no correlation of autopsy findings with a modern neuroimaging assessment tumor burden.To correlate in PCNSL to MRI findings.From authors' database immunocompetent patients diagnosed between 1985 and 2001, 10 who died had at were identified. Their pathology was compared MR scans obtained shortly before death.The median patient age 60 years (range 44 80 years). There six men...
Trastuzumab, which is a large monoclonal antibody that efficacious in the treatment of patients with HER-2/neu-overexpressing, metastatic breast carcinoma, does not penetrate blood-brain barrier and, thus, may allow brain to become sanctuary site for micrometastases. Few studies have compared risk central nervous system (CNS) metastases treated or without trastuzumab.The authors conducted retrospective cohort study 264 who did receive trastuzumab therapy 79 received therapy. The was powered...
Abstract Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones women as potential protective factors for these tumors, with inconsistent results. genome-wide association studies (GWAS) not stratified by sex. Potential sex-specific genetic effects were assessed autosomal SNPs and chromosome variants all glioma, GBM non-GBM patients using data from four previous GWAS. Datasets analyzed sex-stratified logistic regression...
To assess the reporting quality of randomized controlled trials (RCTs) in primary treatment brain tumors and to identify significant predictors quality.Two investigators searched MEDLINE, EMBASE, bibliographies retrieved articles for RCTs published between January 1990 December 2004. We assessed overall key methodologic factors (allocation concealment, blinding, intention treat [ITT]). Two also rated independently using items from revised Consolidated Standards Reporting Trials statement. A...
Adult medulloblastoma accounts for less than 1% of adult intracranial tumors. Previous survival studies have been inconclusive because small sample sizes and patient ascertainment bias.The Surveillance, Epidemiology, End Results (SEER) 17 registries database, released April 2007, was used to assess rates prognostic factors in this disease. SEER*Stat calculate observed relative 2-, 5-, 10-, 15-, 20-year Cox Proportion Hazard Regression modeling evaluate variables.Four hundred fifty-four...
Decades of research have established only a few etiological factors for glioma, which is rare and highly fatal brain cancer. Common methodological challenges among glioma studies include small sample sizes, heterogeneity tumor subtypes, retrospective exposure assessment. Here, we briefly describe the Glioma International Case-Control (GICC) Study (recruitment, 2010–2013), study being conducted by Genetic Epidemiology Consortium that integrates data from multiple collection sites, uses common...
Few studies had investigated genome-wide methylation in glioblastoma multiforme (GBM). Our goals were to study differential across the genome gene promoters using an array-based method, as well repetitive elements surrogate global markers. The discovery sample set for this consisted of 54 GBM from Columbia University and Case Western Reserve University, 24 brain controls New York Brain Bank. We assembled a validation dataset data 162 TCGA 140 dbGAP. HumanMethylation27 Analysis Bead-Chips...
An inverse relationship between allergies with glioma risk has been reported in several but not all epidemiological observational studies. We performed an analysis of genetic variants associated atopy to assess the using Mendelian randomisation (MR), approach unaffected by biases from temporal variability and reverse causation that might have affected earlier investigations. Two-sample MR was undertaken genome-wide association study data. used single nucleotide polymorphisms (SNPs) atopic...
7509 Background: ADI-001 is a first-in-class allogeneic gamma delta (γδ) CAR T-cell therapy targeting the B-cell antigen CD20. also has both adaptive and innate cytotoxic effector functions to complement targeting, potentially enhancing efficacy reducing possibility of tumor escape due loss. expresses MHC independent γδ T cell receptors, thus lowering risk graft versus host disease (GvHD) without need for gene-editing. Methods: This phase 1 trial evaluates in adults with relapsed/refractory...
There are few and conflicting studies on the optimal timing of initial cranial radiation in treatment glioblastoma multiforme (GBM) but none them have addressed this issue elderly population. We used linked Surveillance, Epidemiology, End Results (SEER) Medicare database to investigate whether time interval from surgery initiation is a significant prognostic factor for survival subjects aged ≥65 years with newly diagnosed GBM. Cox modeling was assess effect waiting overall survival....
3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) have shown inverse associations with cancer risks, but the results been inconsistent. As there are no previous published data in brain tumors, we conducted a case-control study to investigate statin therapy and risk of glioma. We further evaluated use nonsteriodal anti-inflammatory drugs (NSAIDs) these tumors. recruited newly diagnosed glioma cases frequency matched controls at Columbia University California San...
Abstract Varicella zoster virus ( VZV ) is a neurotropic α ‐herpesvirus that causes chickenpox and establishes life‐long latency in the cranial nerve dorsal root ganglia of host. To date, only consistently reported to have an inverse association with glioma. The Glioma International Case‐Control Study GICC large, multisite consortium data on 4533 cases 4171 controls collected across five countries. Here, we utilized confirm previously associations between history glioma risk one largest...
The purpose of this study was to evaluate the distribution glioma-related seizures and seizure control at time tumor diagnosis with respect histologic subtypes, treatment patient characteristics, compare history preceding (or enrollment) between glioma patients healthy controls. Glioma International Case Control (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, occupational history. Cases from eight centers were also asked detailed...
Obesity and related factors have been implicated as possible aetiological for the development of glioma in epidemiological observation studies. We used genetic markers a Mendelian randomisation framework to examine whether obesity-related traits influence risk. This methodology reduces bias from confounding is not affected by reverse causation. Genetic instruments were identified 10 key risk factors, their association with was evaluated using data genome-wide study 12,488 patients 18,169...