A5032536459- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Pituitary Gland Disorders and Treatments
- Kruppel-like factors research
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- Circular RNAs in diseases
- Meningioma and schwannoma management
- Cerebrospinal fluid and hydrocephalus
- RNA Research and Splicing
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Cancer Research and Treatments
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Neurofibromatosis and Schwannoma Cases
- Immune cells in cancer
- Mesenchymal stem cell research
- Cancer, Lipids, and Metabolism
Second Affiliated Hospital of Xi'an Jiaotong University
2014-2025
Huazhong University of Science and Technology
2011-2024
Tongji Hospital
2011-2024
Jilin University
2024
Ruijin Hospital
2013-2024
Shanghai Jiao Tong University
2013-2024
First Affiliated Hospital of Xi'an Jiaotong University
2021
Umeå University
2010-2013
Jilin City Central Hospital
2005
Ferroptosis is an iron-dependent form of cell death triggered by the excessive accumulation lipid peroxides. Understanding regulatory mechanisms ferroptosis and developing strategies to target this process hold significant clinical applications in tumor therapy. Our study aims search for novel candidate genes involved regulation investigate their mechanism action We employed a CRISPR-Cas9 library perform genome-wide screen under inducer treatment conditions, revealing Scavenger Receptor...
Background:This study aimed to investigate the expression and significance of 5 types miRNAs in breast cancer provide a theoretical practical foundation for using these diagnosis treatment cancer, thereby improving medical services. Material/Methods:Stem-loop real-time RT-PCR was used detect levels miR-145, miR-21, miR-10b, miR-125a, miR-206 35 cases adjacent normal tissues, analyze relationship with clinicopathological features cancer.The estrogen receptor (ER) progesterone (PR) were...
Objective:The aim of this study was to analyze the effects saikosaponin-d (SSd) on autophagy activity and radiosensitivity hepatoma cells, elucidate its related molecular mechanisms.Methods: The growth SMMC-7721 MHCC97L cells were detected by clonal formation survival fraction.Flow cytometry used detect changes apoptosis cells.The morphological observed transmission electron microscopy further quantitatively laser confocal microscopy.The expressions proteins Western blotting.Results: SSd can...
Rapamycin (Rapa), an inhibitor of mammalian target (mTOR), is immunosuppressive agent that has anti-proliferative effects on some tumors. This study aims to investigate the Rapa suppressing proliferation pancreatic carcinoma PC-2 cells in vitro and its molecular mechanism involved antitumor activities. MTT assays showed inhibition was a time- dose-dependent manner. By using transmission electron microscopy, apoptosis bodies formation abundant autophagic vacuoles were observed after...
BackgroundThe leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins constitute an integral membrane protein family that has three members: LRIG1, LRIG2, LRIG3. LRIG1 negatively regulates growth factor signaling, but little is known regarding the functions of LRIG2 In oligodendroglial brain tumors, high expression correlates with poor patient survival. Lrig1 Lrig3 knockout mice are viable, there have been no reports on Lrig2-deficient to date. Methodology/Principal...
Saikosaponin-d (SSd), a monomer terpenoid purified from the Chinese herbal drug Radix bupleuri, has multiple effects, including anticancer properties. However, effect of SSd on tumors exposed to radiation is largely unknown. To investigate radiosensitizing and its possible mechanism, we combined with therapy treat SMMC-7721 hepatocellular carcinoma cells under oxia hypoxia. Cell growth, apoptosis, cell cycle distribution were examined after treatment alone, their combinations The protein...
Hyperglycemia and hypertension are considered to be the two leading risk factors for vascular disease in diabetic patients. However, few pharmacologic agents could provide a combinational therapy controlling hyperglycemia at same time diabetes. The objectives of this study investigate whether berberine treatment directly reduce blood pressure identify molecular mechanism underlying protection rats. Berberine was intragastrically administered with different dosages 50, 100 200 mg/kg/day rats...
Abnormal activation of the Wnt/β‐catenin signaling pathway is common in human cancers. Several studies have demonstrated that SRY (sex‐determining region Y)‐box (SOX) family genes serve as either tumor suppressor or oncogenes by regulating Wnt different However, role SOX1 breast cancer and underlying mechanism still unclear. The aim this study was to explore effect on breasted cell growth invasion. In study, we established overexpressed investigated its function vitro experiments....
Free radical damage caused by ferrous iron is involved in the pathogenesis of secondary brain injury after intracerebral hemorrhage (ICH). NF-E2-related factor 2 (Nrf2), a major phase II gene regulator that binds to antioxidant response element, represents an important cellular cytoprotective mechanism against oxidative damage. We hypothesized Nrf2 might protect astrocytes from Fe2+. Therefore, we examined cytotoxicity primary induced overload and evaluated effects Fe2+ on expression. The...
Intracerebral hemorrhage (ICH) is a particularly severe form of stroke, and reactive astrogliosis common response following injury to the central nervous system (CNS). Mesenchymal stem cells (MSCs) are reported promote neurogenesis alleviate late side effects in injured brain regions. Gap junctions (Gjs) abundant brain, where richest connexin (Cx) Cx43, most prominently expressed astrocytes. Nuclear factor erythroid 2-related 2 (Nrf2) an essential transcription regulating antioxidant...
The course of prostate cancer varies greatly, and additional prognostic markers are needed. Leucine-rich repeats immunoglobulin-like domains protein 1 (LRIG1) is an endogenous inhibitor growth factor signaling a proposed tumor suppressor. Publicly available gene expression datasets indicate that LRIG1 may be overexpressed in cancer. In our study, the was evaluated for first time. Immunohistochemistry performed on tissue microarrays from two different patient series: 355 Swedish patients...
Secondary injury mediated by oxidative stress leads to deterioration of neurological function after intracerebral hemorrhage (ICH). Cortical astrocytes are one the most important cells in central nervous system (CNS). It is absolutely critical maintain redox homeostasis protecting stress. Hemin a product hemoglobin degradation, which has strong toxicity and can induce reactive oxygen species (ROS). Melatonin (Mel) its metabolites well tolerated without toxicity, prevent tissue damage as...
Radiotherapy for liver cancer can affect the level of autophagy in cells, and effective regulation increase radiosensitivity cells.Saikosaponin-d (SSd) is an active ingredient extracted from traditional Chinese medicine Bupleurum. We have confirmed previously vitro experiments that SSd significantly induce apoptosis cells.This study explored role SSd-mediated cells. MTT clone formation showed radiation inhibit proliferation hepatoma cells reduce colony After addition SSd, inhibitory effect...
Self-renewal of glioma stem cells (GSCs) is responsible for glioblastoma (GBM) therapy resistance and recurrence. Tumor necrosis factor α (TNFα) TNF signaling pathway display an antitumor activity in preclinical models tumor patients. However, TNFα exhibits no significance clinical prognosis based on the Glioma Genome Atlas database. This study aimed to explore whether microenvironment maintains self-renewal GSCs promotes worse
In the present study, we investigated in vitro and vivo antitumor effects of crude extract Scutellaria barbate (CE-SB) on mouse hepatoma H22 cells. The MTT assay was used to determine growth inhibition cells vitro. therapeutic CE-SB were determined using tumor bearing mice. Besides, body weight, thymus index spleen mice also measured. inhibitory rate (IR) calculated according mean weight (MWT). phagocytotic function macrophages examined by observing peritoneal phagocytize chicken RBC....