A5068545579- Neuroblastoma Research and Treatments
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Telomeres, Telomerase, and Senescence
- Sleep and Wakefulness Research
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Microtubule and mitosis dynamics
- Sleep and related disorders
- PARP inhibition in cancer therapy
- Cancer therapeutics and mechanisms
- Virus-based gene therapy research
- Hormonal Regulation and Hypertension
- Memory Processes and Influences
- Cancer Genomics and Diagnostics
- Cell death mechanisms and regulation
- Receptor Mechanisms and Signaling
- Emergency and Acute Care Studies
- Adrenal and Paraganglionic Tumors
- RNA and protein synthesis mechanisms
- Genetic Associations and Epidemiology
- Signaling Pathways in Disease
- Zebrafish Biomedical Research Applications
- Cognitive Abilities and Testing
- Erythrocyte Function and Pathophysiology
University of Cologne
2010-2023
Robert Koch Institute
2023
University Hospital Cologne
2010-2022
University of Fribourg
2019
University of Zurich
2013-2015
University of Basel
2011-2015
University Hospital of Zurich
2014
Laboratory of Molecular Genetics
2012-2013
Ghent University Hospital
2011
German Cancer Research Center
2011
A systematic look at a childhood tumor Neuroblastomas—the most common type in infants—develop from fetal nerve cells, and their clinical course is highly variable. Some neuroblastomas are fatal despite treatment, whereas others respond well to treatment some undergo spontaneous regression without treatment. Ackermann et al. sequenced more than 400 pretreatment identified molecular features that characterize the three distinct outcomes. Low-risk tumors lack telomere maintenance mechanisms,...
Neuroblastoma is an embryonal malignancy of the sympathetic nervous system. Spontaneous regression and differentiation neuroblastoma observed in a subset patients, has been suggested to represent delayed activation physiologic molecular programs fetal neuroblasts. Homeobox genes constitute important family transcription factors, which play fundamental role morphogenesis cell during embryogenesis. In this study, we demonstrate that expression majority human HOX class I homeobox significantly...
Sleep and memory are stable heritable traits that strongly differ between individuals. benefits consolidation, the amount of slow wave sleep, sleep spindles, rapid eye movement have been repeatedly identified as reliable predictors for declarative and/or emotional memories retrieved after a consolidation period filled with sleep. These studies typically encompass small sample sizes, increasing probability overestimating real association strength. In large we tested whether individual...
Abstract Background Genomic alterations of the anaplastic lymphoma kinase gene ( ALK ) occur recurrently in neuroblastoma, a pediatric malignancy sympathetic nervous system. However, information on their development over time has remained sparse. Methods were assessed neuroblastomas at diagnosis and/or relapse from total 943 patients, covering all stages disease. Longitudinal diagnostic and relapsed samples individual patients was available 101 102 cases for mutation amplification status,...
Genomic alterations of the anaplastic lymphoma kinase (ALK) gene have been postulated to contribute neuroblastoma pathogenesis. This study aimed determine interrelation ALK mutations, expression levels, and clinical phenotype in primary neuroblastoma.The genomic status global patterns were examined 263 neuroblastomas. Allele-specific was determined by cDNA cloning sequencing. Associations levels with phenotypes transcriptomic profiles compared.Nonsynonymous point mutations detected 21...
Working memory, the capacity of actively maintaining task-relevant information during a cognitive task, is heritable trait. memory deficits are characteristic for many psychiatric disorders. We performed genome-wide gene set enrichment analyses in multiple independent data sets young and aged cognitively healthy subjects (n = 2,824) large schizophrenia case-control sample 32,143). The voltage-gated cation channel activity set, consisting genes related to neuronal excitability, was robustly...
Abstract Sleep is vital for human health and wellbeing, sleep disturbances are comorbid to many mental physiological disorders. Music consistently improves subjective quality, whereas results objective parameters diverge. These inconsistencies might be due inter-individual differences. Here, 27 female subjects listened either music or a control text before 90 minutes nap in within-subjects design. We show that improved quality as compared the condition. In all participants, resulted reduced...
High-risk neuroblastoma remains a therapeutic challenge for pediatric oncologists. The Polo-like kinase 1 (PLK1) is highly expressed in many human cancers and target of the novel small-molecule inhibitor BI 2536, which has shown promising anticancer activity adult malignancies. Here, we investigated effect 2536 on cells vitro vivo to explore PLK1 as potential high-risk therapy.PLK1 transcript levels were analyzed by microarrays 476 primary specimens, correlation with prognostic markers...
Strong memory of a traumatic event is thought to contribute the development and symptoms posttraumatic stress disorder (PTSD). Therefore, genetic predisposition build strong memories could lead increased risk for PTSD after event. Here we show that variability gene encoding PKCα ( PRKCA ) was associated with capacity—including aversive memory—in nontraumatized subjects European descent. This finding replicated in an independent sample subjects, who additionally underwent functional magnetic...
Telomere maintenance is a hallmark of high-risk neuroblastoma; however, the contribution telomerase and alternative lengthening telomeres (ALT) to clinical phenotypes has remained unclear. We aimed determine relevance activation versus ALT as biomarkers in pretreatment neuroblastoma assess potential value therapeutic target.The genomic status TERT MYCN was assessed 457 neuroblastomas by fluorescence situ hybridization. examined 273 tumors detection ALT-associated promyelocytic leukemia...
Extensive evidence indicates that women outperform men in episodic memory tasks. Furthermore, are known to evaluate emotional stimuli as more arousing than men. Because arousal typically increases formation, the females' advantage might be pronounced for emotionally information neutral information. Here, we report behavioral data from 3398 subjects, who performed picture rating and tasks, corresponding fMRI up 696 subjects. We were interested interaction between sex valence category on...
OBJECTIVE: To determine the proportion of correct emergency department (ED) diagnoses and hospital discharge diagnoses, in comparison with final at end a 30-day follow-up, patients presenting nonspecific complaints (NSCs) to ED; differences between male female missed diagnoses. METHODS: Prospective observational study. Diagnoses made ED, were compared. RESULTS: Of 22,782 nontrauma ED from May 2007 until 2009, 9,926 triaged as severity index level 2 or 3, whom 789 presented NSCs. After...
Neuroblastoma is an embryonal pediatric tumor that originates from the developing sympathetic nervous system and shows a broad range of clinical behavior, ranging fatal progression to differentiation into benign ganglioneuroma. In experimental neuroblastoma systems, retinoic acid (RA) effectively induces neuronal differentiation, RA treatment has been therefore integrated in current therapies. However, molecular mechanisms underlying are still poorly understood. We here investigated role...
Polo-like kinase 1 (PLK1) is a serine/threonine that promotes G2/M-phase transition, expressed in elevated levels high-risk neuroblastomas and correlates with unfavorable patient outcome. Recently, we others have presented PLK1 as potential drug target for neuroblastoma, reported the BI2536 inhibitor showed antitumoral actvity preclinical neuroblastoma models. Here analyzed effects of GSK461364, competitive ATP binding to PLK1, on typical tumorigenic properties vitro vivo GSK461364 treatment...
Sleep disturbances are an important risk factor for stress-related diseases such as burnout or depression. In particular, slow-wave activity during sleep might be eminently relevant optimal maintenance of mental health and cognitive functioning. spite the clinical importance pertinence processes in everyday life, physiological mechanisms association between stress, cognition not well understood. present study, we carefully mapped time course influence a psychosocial stressor on architecture...
Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense screen episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like protein 1 (CTNNBL1) was significantly (P=7 × 10−8) associated verbal memory performance in cognitively healthy cohort from Switzerland (n=1073) and replicated second Serbia (n=524; P=0.003). Gene expression studies showed...
Abstract Cortisol is known to affect memory processes. On the one hand, stress-induced or pharmacologically induced elevations of cortisol levels enhance consolidation. other such experimentally have been shown impair retrieval. However, effects individual differences in basal on processes remain largely unknown. Here we tested whether predict picture learning and recall a large sample. A total 1225 healthy young women men viewed two different sets emotional neutral pictures consecutive...
Segmental genomic copy number alterations, such as loss of 11q or 3p and gain 17q, are well established markers poor outcome in neuroblastoma, have been suggested to comprise tumor suppressor genes oncogenes, respectively. The gene forkhead box P1 (FOXP1) maps chromosome 3p14.1, a locus deleted many human cancers including neuroblastoma. FoxP1 belongs family winged-helix transcription factors that involved processes cellular proliferation, differentiation neoplastic transformation....
OBJECTIVE: In an emergency department, discharge communication represents a key step in medical care. The efficiency of this doctor-patient interaction could be hampered by two bounds: limited time care and patients’ mind’s capacity to encode, store maintain information. Such limitations are the focus study. Specifically, we examine number items physicians deem crucial necessary estimated present them. METHODS: A vignette patient with chest pain was presented 47 (38 internists, 9...