A5101889704- Insect Pest Control Strategies
- Mosquito-borne diseases and control
- Insect Resistance and Genetics
- Insect and Pesticide Research
- Neurobiology and Insect Physiology Research
- Ion channel regulation and function
- Beetle Biology and Toxicology Studies
- Antibiotics Pharmacokinetics and Efficacy
- Insect Utilization and Effects
- Cancer Immunotherapy and Biomarkers
- Insect behavior and control techniques
- Insect-Plant Interactions and Control
- Ferroptosis and cancer prognosis
- Malaria Research and Control
- Alcohol Consumption and Health Effects
- Prenatal Substance Exposure Effects
- Body Composition Measurement Techniques
- Venomous Animal Envenomation and Studies
- Liver physiology and pathology
- Paraquat toxicity studies and treatments
- Hormonal and reproductive studies
- Infectious Diseases and Mycology
- Voice and Speech Disorders
- Pharmacological Effects and Toxicity Studies
- Tracheal and airway disorders
Zhejiang A & F University
2021-2025
Guangxi University of Science and Technology
2025
Chinese PLA General Hospital
2003-2024
Nanjing Agricultural University
2024
Zhejiang University
2013-2021
Henan Cancer Hospital
2021
Zhengzhou University
2021
China Jiliang University
2020
Academy of Military Medical Sciences
2020
Institute of Microbiology
2020
The widely used triazole fungicides have the potential to disrupt endocrine system, but little is known of such effects or underlying mechanisms hexaconazole (HEX) and tebuconazole (TEB) in fish. In present study, zebrafish (Danio rerio) embryos were exposed various concentrations HEX (0.625, 1.25 2.5 mg/L) TEB (1, 2 4 from fertilization 120 h post-fertilization (hpf). whole body content thyroid hormone transcription genes hypothalamic-pituitary-thyroid (HPT) axis analyzed. results showed...
Abstract Pyrethrum extracts from flower heads of Chrysanthemum spp. have been used worldwide in insecticides and repellents. While the molecular mechanisms its insecticidal action are known, basis pyrethrum repellency remains a mystery. In this study, we find that principal components pyrethrum, pyrethrins, minor component, (E)-β-farnesene (EBF), each activate specific type olfactory receptor neurons Aedes aegypti mosquitoes. We identify Ae. odorant 31 (AaOr31) as cognate Or for EBF...
Background Multiple mutations in the voltage-gated sodium channel have been associated with knockdown resistance (kdr) to DDT and pyrethroid insecticides a major human disease vector Aedes aegypti. One mutation, V1016G, confers pyrethroids, but different substitution same position V1016I alone had no effect. In pyrethroid-resistant Ae. aegypti populations, is often linked another F1534C, which only Type I pyrethroids including permethrin (PMT), not II deltamethrin (DMT). Mosquitoes carrying...
Abstract The WHO has declared SARS-CoV-2 outbreak a public health emergency of international concern. However, to date, there was hardly any study in characterizing the immune responses, especially adaptive responses infection. In this study, we collected blood from COVID-19 patients who have recently become virus-free and therefore were discharged, analyzed their SARS-CoV-2-specific antibody T cell responses. We observed humoral cellular immunity patients. Both detected newly discharged...
One of the major limitations in clinical use existing oxazolidinone antibiotics is their characteristic adverse reactions, particular thrombocytopenia. In anti-infective treatment, if patients are suspected having drug-induced thrombocytopenia, first step to immediately discontinue offending drug. Even with severe infections, antibacterial drug may need be changed or treatment discontinued because thrombocytopenia have a more serious prognosis. addition, patient needs continue after...
Sarcopenia, characterized by the gradual decline of muscle mass and strength, seriously affects health mobility older adults. The purpose this study is to investigate risk factors for sarcopenia, particularly relationship between chronic diseases lifestyle in individuals aged 60 over. This used data from Longitudinal Study on Health Retirement China (CHARLS) collected 2011 2015. All eligible participants were classified according standards established Asian Sarcopenia Working Group 2019....
Numerous essential oils have been well acknowledged as eco-friendly alternatives to combat insect pests due synthetic insecticide-induced pest resistance and environment pollution. As a highly commercial oil, tea tree oil exhibits excellent insecticidal repellent activities. However, the molecular mechanism of olfactory system mediating oil-induced repellency against remains unknown. In our study, mosquito was used suitable model examine pests. The results showed that exhibited spatial...
Chlorantraniliprole, an anthranilic diamide insecticide, is widely used for controlling lepidopteran pests, because of its high insecticidal activity. However, overuse chlorantraniliprole has led to the selection resistance in many insect including Chilo suppressalis (Lepidoptera:Crambidae), one most damaging rice pests China. In this study, levels C. was surveyed from eight populations three provinces The were ranged 34.4-fold 284.0-fold compared with a susceptible population. Then, 15402...
Background Volatile pyrethroid insecticides, such as transfluthrin, have received increasing attention for their potent repellent activities in recent years controlling human disease vectors. It has been long understood that pyrethroids kill insects by promoting activation and inhibiting inactivation of voltage-gated sodium channels. However, the mechanism repellency remains poorly controversial. Methodology/Principal findings Here, we show transfluthrin repels Aedes aegypti a hand-in-cage...
Abstract BACKGROUND The Asian tiger mosquito, Aedes albopictus , is a competent vector for the spread of several viral arboviruses including dengue, chikungunya, and Zika. Several vital mosquito behaviors linked to survival reproduction are primarily dependent on sophisticated olfactory system semiochemical perception. However, limited number studies has hampered our understanding relationship between A. acute complex chemical world. RESULTS Here, we performed qRT‐PCR assay antennae from...
Pyrethrum extract from dry flowers of Tanacetum cinerariifolium (formally Chrysanthemum ) has been used globally as a popular insect repellent against arthropod pests for thousands years. However, the mechanistic basis pyrethrum repellency remains unknown. In this study, we found that spatially repels and activates olfactory responses in Drosophila melanogaster , genetically tractable model insect, closely-related D . suzukii which is serious invasive fruit crop pest. The discovery spatial...
Pyrethrum from dry flowers of Chrysanthemum is a well-known botanical insecticide and repellent. Its insecticidal activity attributes to its six esters, collectively known as pyrethrins. Pyrethrins synthetic analogs pyrethroids exert their toxic action by modifying the function voltage-gated sodium channels. Aside activity, pyrethrum has also been used repel mosquitoes for centuries. Today, continues be an active ingredient in mosquito coils other mosquito-repellent devices globally....
The Asian tiger mosquito Aedes albopictus is a competent vector of several viral arboviruses including yellow fever, dengue and chikungunya. Several vital behaviors (e.g., feeding, host-seeking, mating, oviposition) are primarily dependent on the olfactory system for semiochemicals detection discrimination. However, limited number studies hampers our understanding relationships between Ae. complex chemical world. We performed RT-qPCR assay antennae mosquitoes different sexes, ages...
Levetiracetam may cause acute renal failure and myoclonic encephalopathy at high plasma levels, particularly in patients with impairment. The aim of this study was to develop a physiologically based pharmacokinetic (PBPK) model predict levetiracetam pharmacokinetics Chinese adults epilepsy impairment define appropriate dosing regimen.PBPK models for healthy subjects were developed, validated, adapted. Furthermore, we predicted the steady-state trough peak concentrations using final PBPK...
Phyllotreta striolata, the striped flea beetle, is one of most destructive pests in Brassicaceae plants worldwide. Given drawbacks associated with long-term use chemical insecticides, green strategies based on ecology are an effective alternative for beetle control. However, lack information has hindered development biocontrol strategies. In this report, we identified two odorants, (S)-cis-verbenol and (-)-verbenone, which displayed significant attraction P. striolata (p < 0.05), indicating...
The striped flea beetle, Phyllotreta striolata, is one of the most destructive pests Cruciferae crops worldwide. RNA interference (RNAi) a promising alternative strategy for pest biological control, which overcomes weakness synthetic insecticides, such as resistance, food safety problems and toxicity to non-target insects. homolog Spt16/FACT, dre4 plays critical role in process gene transcription, DNA repair, replication; however, effects silencing P. striolata remain elusive. In this study,...
Abstract RNA interference is an efficient approach for gene function identification and a potential novel strategy selectively controlling pests. The red flour beetle, Tribolium castaneum (Coleoptera: Tenebrionidae), major global storage pest, which causes great economic loss. Juvenile hormone esterase (JHE), carboxylesterase, responsible the degradation of juvenile hormone. However, knockdown effect jhe on metamorphosis pupae or adult in T. unknown. In this study, we analyzed expression...