A5041782993- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Cell Adhesion Molecules Research
- Renal Diseases and Glomerulopathies
- Cellular Mechanics and Interactions
- Liver Disease Diagnosis and Treatment
- Blood groups and transfusion
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Protein Kinase Regulation and GTPase Signaling
- Polyomavirus and related diseases
- Neuroscience and Neuropharmacology Research
- Renal and Vascular Pathologies
- Receptor Mechanisms and Signaling
- Cancer-related gene regulation
- Monoclonal and Polyclonal Antibodies Research
- Cytomegalovirus and herpesvirus research
- Nicotinic Acetylcholine Receptors Study
- Ubiquitin and proteasome pathways
- Cardiac tumors and thrombi
- Healthcare Systems and Challenges
- Chromatin Remodeling and Cancer
Johns Hopkins University
2004-2024
Sidney Kimmel Comprehensive Cancer Center
2024
University of Baltimore
2024
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2021-2023
Fred Hutch Cancer Center
2019-2023
Cancer Research Center
2021
Dartmouth–Hitchcock Medical Center
2014
Johns Hopkins Medicine
2004-2011
Park Terrace Care Center
2007
Torbay Hospital
2007
More than 20,000 candidates for kidney transplantation in the United States are sensitized to HLA and may have a prolonged wait transplant, with reduced rate an increased of death. One solution is perform live-donor renal after depletion donor-specific anti-HLA antibodies. Whether such antibody results survival benefit as compared waiting HLA-compatible unknown.We used protocol that included plasmapheresis administration low-dose intravenous immune globulin desensitize 211 HLA-sensitized...
The present study was undertaken to determine if estrogens protect female rats from the neurodegenerative effects of middle cerebral artery (MCA) occlusion. were ovariectomized and 7 or 8 days later various estrogen preparations administered before after MCA Pretreatment with 17beta-estradiol (17beta-E2) a brain-targeted 17beta-E2 chemical delivery system (CDS) decreased mortality 65% in 22% 17beta-E2-treated 16% CDS-treated rats. This marked reduction accompanied by ischemic area brain...
Current billing practices and mandates to report surgical outcomes are disincentives treatment of obese patients, who at increased risk for longer hospital stays higher complication rates. The objective this study was quantify the independent association between body mass index (BMI) waiting time kidney transplantation identify potential provider bias against obese. A secondary data analysis performed a prospective cohort 132,353 patients were registered in United States 1995 2006. Among all...
Although donation after cardiac death (DCD) kidneys have a high incidence of delayed graft function (DGF) and been considered marginal, no tool for stratifying risk loss nor specific policy governing their allocation exist. We compared outcomes 2562 DCD, 62 800 standard criteria donor (SCD) 12 812 expanded (ECD) transplants reported between 1993 2005, evaluated factors associated with DGF in DCD kidneys. Donor age was the only criterion used definition ECD that independently predicted among...
The requirements for potent immunosuppression coupled with the formidable risk of irreversible antibody-mediated rejection (AMR) have thus far limited expansion ABO incompatible (ABOi) kidney transplantation. We present a retrospective review our single-center experience 60 consecutive ABOi transplants and describe evolution treatment protocol to one that consists only brief escalation in without long-term B-cell suppression from splenectomy or anti-CD20. 1-, 3-, 5-year graft survival rates...
Biopsies of ABO-incompatible and positive crossmatch (HLA-incompatible) renal allografts were retrospectively examined to compare results C4d C3d staining, the correlation between such staining histologic findings suggestive antibody-mediated rejection (AMR). A total 75 biopsies (55 protocol, 17 for graft dysfunction, 3 other indications) 24 grafts 244 (103 129 12 66 HLA-incompatible examined; all stained approximately 40% C3d. In grafts, 80% protocol 59% performed dysfunction showed in...
First proposed 2 decades ago, live kidney paired donation (KPD) was considered a promising new approach to addressing the shortage of organs for transplantation. Ethical, administrative, and logistical barriers initially proved formidable prevented implementation KPD programs in United States.To determine feasibility effectiveness management patients with incompatible donors.Prospective series donations matched transplanted from pool blood type or crossmatch donors recipients end-stage renal...
When the United Network for Organ Sharing changed its algorithm liver allocation to model end-stage disease (MELD) system in 2002, highest priority shifted patients with renal insufficiency as a major component of their disease. An unintended consequence new was rapid increase number simultaneous liver-kidney transplants (SLK) being performed yearly.Adult recipients deceased donor (LT, n=19,137), kidney (n=33,712), and SLK (n=1,032) between 1987 2006 were evaluated based on data. Recipients...
Liver transplantation from donation after cardiac death (DCD) donors is an increasingly common approach for expansion of the donor organ supply. However, with DCD livers results in inferior graft survival. In this study, we examined and recipient characteristics that are associated poor allograft outcomes present a set criteria permit survival comparable to brain (DBD) grafts both low- high-risk recipients.The United Network Organ Sharing/Organ Procurement Transplantation Registry between...
Most successful protocols for renal transplantation across ABO incompatible (ABOi) barriers have utilized splenectomy as part of the pre-conditioning process. We recently described ABOi using anti-CD20 monoclonal antibody in lieu splenectomy. In current study, we hypothesized that plasmapheresis (PP) and low dose CMV hyper-immunoglobulin (CMVIg) alone would be sufficient to achieve engraftment kidneys. describe four blood type patients who received live donor transplants from A1 (two...
Several treatment options exist for the management of Budd-Chiari syndrome (BCS), yet relative role and timing liver transplantation (LT) remain poorly defined. Small case series published to date have not been able delineate impact comorbidities thromboembolic complications BCS on survival after LT. To better understand outcomes LT BCS, we analyzed 510 transplants performed this disease in United States between 1987 2006. Risk factors predicting graft loss or patient death included...
Abstract Several novel anabaseine‐derived compounds were investigated with respect to their ability displace high affinity [ 3 H]cytisine binding in rat brain membranes, as well improve passive and active avoidance behaviors nucleus basalis‐lesioned rats. The relative potencies for displacement of 1 nM IC50 parentheses: anabaseine (70 nM) > DMAB (140 = DMXB (150 anabasine (270 DMAC (420 nM). Passive behavior bilaterally rats was improved by each these drugs an extent comparable that...
C4d deposition in peritubular capillaries is a specific marker for the presence of antidonor antibodies renal transplant recipients and usually associated with antibody-mediated rejection (AMR) conventional allografts. In ABO-incompatible grafts, however, capillary often present on protocol biopsies lacking histologic features AMR; significance this setting remains unclear. For addressing this, data from 33 patients who received allografts (after desensitization) were retrospectively...
Elderly liver donors (ELDs) represent a possible expansion of the donor pool, although there is great reluctance to use ELDs because reports that increasing age predicts graft loss and patient death. The goal this study was identify subgroup recipients who would be least affected by increased thus best suited receive grafts from ELDs. A national registry deceased transplants 2002–2005 analyzed. aged 70–92 (n = 1043) were compared with average (ALDs) 18–69 15,878) ideal (ILDs) 18–39 6842)....
To quantify the independent association between obesity and access to liver transplantation.Obesity is associated with higher complication rates, longer hospitalization, worse survival after transplantation. Nevertheless, transplantation provides benefit patients end-stage disease, regardless of body mass index (BMI). We hypothesized that, despite benefit, providers were reluctant transplant obese because inherent difficulty these cases their inferior outcomes. Our goal was BMI waiting time...
Activating mutations in PIK3CA are frequently found estrogen-receptor-positive (ER+) breast cancer, and the combination of phosphatidylinositol 3-kinase (PI3K) inhibitor alpelisib with anti-ER inhibitors is approved for therapy. We have previously demonstrated that PI3K pathway regulates ER activity through phosphorylation chromatin modifier KMT2D. Here, we discovered a methylation site on KMT2D, at K1330 directly adjacent to S1331, catalyzed by lysine methyltransferase SMYD2. SMYD2 loss...
The broadly neutralizing antibody (bnAb) VRC01 is being evaluated for its efficacy to prevent HIV-1 infection in the Antibody Mediated Prevention (AMP) trials. A secondary objective of AMP utilizes sieve analysis investigate how prevention (PE) varies with envelope (Env) amino acid (AA) sequence features. An exhaustive that tests PE depends on every AA feature sufficient variation would have low statistical power. To design an adequately powered primary AMP, we modeled neutralization as a...