A5101554597- Estrogen and related hormone effects
- Pharmacogenetics and Drug Metabolism
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
- Cancer-related molecular mechanisms research
- Berberine and alkaloids research
- Ferroptosis and cancer prognosis
- Cancer therapeutics and mechanisms
- Advanced biosensing and bioanalysis techniques
- Genomics and Chromatin Dynamics
- Hedgehog Signaling Pathway Studies
- HIV/AIDS drug development and treatment
- Congenital limb and hand anomalies
- Acute Myeloid Leukemia Research
- Cannabis and Cannabinoid Research
- Alcohol Consumption and Health Effects
- Phytoplasmas and Hemiptera pathogens
- Dye analysis and toxicity
- Phosphodiesterase function and regulation
- Mast cells and histamine
- Biosensors and Analytical Detection
- IL-33, ST2, and ILC Pathways
- Identification and Quantification in Food
- Enhanced Recovery After Surgery
- Cholesterol and Lipid Metabolism
First People's Hospital of Yunnan Province
2016-2025
Kunming University of Science and Technology
2016-2025
University of Nottingham Ningbo China
2024
Institute of Vegetables and Flowers
2024
Chinese Academy of Agricultural Sciences
2024
Johns Hopkins University
2023-2024
Guangzhou Blood Center
2023
Third People's Hospital of Yunnan Province
2020
Soochow University
2018
Materials Science & Engineering
2018
Activating mutations in PIK3CA are frequently found estrogen-receptor-positive (ER+) breast cancer, and the combination of phosphatidylinositol 3-kinase (PI3K) inhibitor alpelisib with anti-ER inhibitors is approved for therapy. We have previously demonstrated that PI3K pathway regulates ER activity through phosphorylation chromatin modifier KMT2D. Here, we discovered a methylation site on KMT2D, at K1330 directly adjacent to S1331, catalyzed by lysine methyltransferase SMYD2. SMYD2 loss...
Abstract Background Acute Myeloid Leukemia (AML) generally has a relatively low survival rate after treatment. There is an urgent need to find new biomarkers that may improve the prognosis of patients. Machine-learning tools are more and widely used in screening biomarkers. Methods Least Absolute Shrinkage Selection Operator (LASSO), Support Vector Machine-Recursive Feature Elimination (SVM-RFE), Random Forest (RF), eXtreme Gradient Boosting (XGBoost), lrFuncs, IdaProfile, caretFuncs,...
Translocation renal cell carcinoma (tRCC) presents a significant clinical challenge due to its aggressiveness and limited treatment options. It is primarily driven by fusion oncoproteins (FOs), yet their role in oncogenesis not fully understood. Here, we investigate TFE3 fusions tRCC, focusing on NONO::TFE3 SFPQ::TFE3. We demonstrate that FOs form liquid-like condensates with increased transcriptional activity, localizing target genes promoting proliferation migration. The coiled-coil...
The pharmacogenomics study has been widely used for the of very important pharmacogenetic (VIP) variants among different ethnic groups. However, there is little known about information regarding Bai family. Our aimed to screen polymorphism VIP gene in nationality.We genotyped 81 (selected from PharmGKB database) population and then compared them other 11 major HapMap populations by chi-square test, structure F-statistics (Fst) analysis.Our results indicated that rs20417 (PTGS2), rs4148323...
Background: Lung cancer is one of the most common human malignant diseases. In this study, we aimed to explore association between IL1RL1 genetic polymorphisms and lung risk in Chinese Han population. Methods: We selected genotyped six SNPs gene using Agena MassARRAY system 507 patients healthy controls. The variants was assessed logistic regression calculate odds ratios (ORs) 95% confidence intervals (CIs). Multi-factor dimensionality reduction (MDR) used analyze impact SNP-SNP interactions...
Abstract Phosphodiesterase 4D interacting protein ( PDE4DIP ) interacts with cAMP-specific phosphodiesterase and its abnormal expression promotes the development of hematological malignancies, breast cancer, pineal cell carcinoma. However, there is currently no systematic pan-cancer analysis association between various cancers. Thus, this study aimed to elucidate potential functions in Based on multiple public databases online websites, we conducted comprehensive analyses for cancers,...
A novel competitive electrochemiluminescence (ECL) immunosensor based on CdSe quantum dots was developed for the detection of enrofloxacin (Enro).
Individual differences in drug clinical response are related to pharmacogenomics. The genetic variation of drug-metabolizing enzymes, receptors, and their downstream protein genes is the main factor causing individual response. backgrounds among different ethnic groups quite different. In this study, we aimed detect distribution difference genotype frequency very important pharmacogenetic (VIP) gene variants Lisu.Using chi-squared test, compared frequencies VIP 105 Lisu people with those 26...
Genetic polymorphisms in numerous pharmacogenetics studies were regarded as the essential factors involved response to or metabolism of drugs. These genetic variants called very important pharmacogenetic (VIP) played a role drugs metabolism, which have been summarized PharmGKB database. In this study, we genotyped 80 VIP from 100 members Blang volunteers Yunnan province.Based on database, loci located 47 genes. We used χ2 tests evaluate significant between and other populations, including...
IL-7/IL-7R axis participates in the initiation and progression of lung cancer (LC). This study aimed to explore potential influence polymorphisms on LC risk.In total, 1,010 participants (507 patients 503 healthy controls) were enrolled. Five single-nucleotide (SNPs) IL-7R one SNP IL-7 genotyped included samples with Agena MassARRAY system. OR 95% CIs computed by logistic regression analysis after adjusting for age gender. Stratified analyses demographic clinical characteristics also...
// Chan Zhang 1, * , Heng Ding 2, Yujing Cheng 1 Wanlu Chen Qi Li Qing Run Dai Manlin Luo 3 Department of Blood Transfusion, The First People’s Hospital Yunnan Province, Affiliated Kunming University Science and Technology, 650032, Yunnan, China 2 Honghe Center Station, Mengzi 661100, Second Co-first authors Correspondence to: Luo, email: drmanlinluo@163.com Keywords: drug addiction, ALDH2, single nucleotide polymorphisms (SNPs), case-control study, association study Received:...
Background: Cytochrome P450 (CYP) enzymes are involved in the metabolism of xenobiotic and carcinogen. In study, we evaluated association CYP2J2 CYP2C9 variants with lung cancer. Method: Five polymorphisms four were genotyped 507 cancer patients 505 controls Agena MassARRAY platform. The linkage risk was by odds ratio (OR) 95% confidence interval (CI) genetic models haplotype analyses. objective: To elucidate relationship between gene susceptibility, have performed a case-control study.The...
Metal-regulatory transcription factor 1 (MTF1), a conserved metal-binding in eukaryotes, regulates the proliferation of cancer cells by activating downstream target genes and then participates formation progression tumors, including lung (LC). The expression level MTF1 is down-regulated LC, high associated with good prognosis LC. However, association between polymorphism LC risk has not been explored.
Inflammatory bowel disease (IBD) is affected by interactions between intestinal microbial factors, abnormal inflammation, and an impaired mucosal barrier. Neutrophils (NE) are key players in IBD.
Abstract Background Pharmacogenomics plays a crucial role in individualized therapy, but the variant information of pharmacogenomics Dai population is limited. We therefore aimed to screen very important pharmacogenetic (VIP) and compared differences between other 25 populations. Methods In this study, we genotyped 73 VIP variants from PharmGKB genotype distribution with populations by χ2 test. To assess genetic relationship among 26 populations, performed structure analysis. addition,...
Genetic polymorphism, obviously, has a potential clinical role in determining differences drug efficacy; however, there are no reports about the pharmacogenomic information of Lahu population. Therefore, our research aimed to screen genotypic frequencies very important pharmacogenomics (VIP) mutations and determined between other 11 populations.Agena MassARRAY (AgenaMassARRAY) single nucleotide polymorphism (SNP) genotyping technique was used detect 81 VIP genes Lahu, their were compared...
Lung cancer is the leading cause of death globally. Recent studies have revealed that CYP19A1 gene plays a crucial role in initiation and development. The aim this study was to assess association genetic polymorphisms with risk lung Chinese Han population.This randomly recruited 489 patients 467 healthy controls. genotypes four single nucleotide (SNPs) were identified by Agena MassARRY technique. Genetic model analysis used between variations risk. Odds ratios (ORs) 95% confidence intervals...
Transcriptional responses to the Hedgehog (HH) signaling pathway are primarily modulated by GLI repression in mouse limb. Previous studies suggested a role for BAF chromatin remodeling complex mediating repression. Consistent with this possibility, core protein SMARCC1 is present at most active limb enhancers including majority of enhancers. However, contrast which reduces accessibility, maintains accessibility enhancers, those bound GLI. Moreover, binding GLI-regulated occurs independently...