A5100350245- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Viral-associated cancers and disorders
- Plant Disease Resistance and Genetics
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Axon Guidance and Neuronal Signaling
- DNA Repair Mechanisms
- IL-33, ST2, and ILC Pathways
- Generative Adversarial Networks and Image Synthesis
- Cancer-related gene regulation
- Neurological disorders and treatments
- Glycosylation and Glycoproteins Research
- Circular RNAs in diseases
- Microtubule and mitosis dynamics
- Antibiotics Pharmacokinetics and Efficacy
First Affiliated Hospital of Xi'an Jiaotong University
2012-2025
Xi'an Jiaotong University
2013-2023
Guangzhou Blood Center
2023
Baoji City Central Hospital
2023
University of Toronto
2010
We aimed to develop a preoperative clinical radiomics survival prediction model based on the features via deep learning provide reference basis for assessment and treatment decisions patients with gallbladder carcinoma (GBC). A total of 168 GBC who underwent upper abdominal enhanced CT from one high-volume medical center between January 2011 December 2020 were retrospectively analyzed. The region interest (ROI) was manually outlined by two physicians using 3D Slicer software establish...
Abstract Background Intrahepatic cholangiocarcinoma (iCCA) is a highly lethal malignancy of the biliary tract. Analysis somatic mutational profiling can reveal new prognostic markers and actionable treatment targets. In this study, we explored utility genomic mutation signature tumor burden (TMB) in predicting prognosis iCCA patients. Methods Whole-exome sequencing corresponding clinical data were collected from ICGC portal cBioPortal database to detect mutated genes determine TMB values. To...
The preoperative nutritional status and the immunological have been reported to be independent prognostic factors of patients with intrahepatic cholangiocarcinoma (ICC). This study aimed investigate whether index (PNI) + albumin-bilirubin (ALBI) could a better predictor than PNI ALBI alone in ICC after radical resection.The prediction evaluation PNI, ALBI, PNI+ALBI grade was performed 373 who underwent resection between 2010 2018 at six Chinese tertiary hospitals, external validation...
Abstract Objective We aimed to evaluate the prognosis and adjuvant chemotherapy (ACT) in intrahepatic cholangiocarcinoma (ICC) patients with different etiology after radical resection. Methods A total of 448 ICC who underwent resection between 2010 2018 at ten Chinese tertiary hospitals were analyzed study. These divided into conventional (Con-ICC, n = 261, 58.2%), hepatitis B virus (HBV-ICC, 102, 22.8%) hepatolithiasis (Stone-ICC, 85,19.0%) subtypes according etiology. Propensity score...
The influence of different postoperative recurrence times on the efficacy adjuvant chemotherapy (ACT) for intrahepatic cholangiocarcinoma (ICC) remains unclear. This study aimed to investigate independent risk factors and establish a nomogram prediction model early (recurrence within 1 year) screen patients with ICC ACT.Data from 310 who underwent radical resection between 2010 2018 at eight Chinese tertiary hospitals were used analyze predict recurrence. External validation was conducted...
Accumulating evidence indicates that cell division cycle 7-related protein kinase(CDC7) plays an essential role in tumor cells and it could induces proliferation be related to prognosis multiple types of cancer. However, the biological molecular mechanism CDC7 GBM still remains unclear. In this study, we identified expression was enriched glioblastoma (GBM) tumors functionally required for its associated poor patients. Mechanically, induced radio resistance knock down increased apoptosis...
As the most common intracranial malignant neoplasms, astrocytomas are characterized by high neovascularization and severe peritumoral brain edema (PTBE). Angiogenesis is a prerequisite for growth of solid tumors, including astrocytoma, brain‑specific angiogenesis inhibitor 1 (BAI1) novel inhibitor. In present study, expression levels BAI1, vascular endothelial factor (VEGF) basic fibroblast (bFGF) were investigated using immunohistochemical methods in 90 human astrocytoma specimens various...
Background: Lung cancer is one of the most common human malignant diseases. In this study, we aimed to explore association between IL1RL1 genetic polymorphisms and lung risk in Chinese Han population. Methods: We selected genotyped six SNPs gene using Agena MassARRAY system 507 patients healthy controls. The variants was assessed logistic regression calculate odds ratios (ORs) 95% confidence intervals (CIs). Multi-factor dimensionality reduction (MDR) used analyze impact SNP-SNP interactions...
Abstract Objective We aimed to develop a preoperative clinical radiomics survival prediction model based on the features via deep learning provide reference basis for assessment and treatment decisions patients with gallbladder carcinoma (GBC). Methods A total of 168 GBC who underwent upper abdominal enhanced CT from one high-volume medical center between January 2011 December 2020 were retrospectively analyzed. The region interest (ROI) was manually outlined by two physicians using 3D...
Abstract Teicoplanin is used for the treatment of Methicillin‐resistant Staphylococcus aureus infection. It has been demonstrated that conventional loading regimen was insufficient teicoplanin to achieve target trough plasma concentration ( C min > 10 mg/L). Therefore, a Chinese expert group recommended an optimal dose treat severe Gram‐positive However, there no report about concentration, and safety efficacy therapy in patients since consensus published. The objective this study compare...
Abstract We previously demonstrated that cancer‐associated fibroblasts (CAFs) promoted the proliferation of gallbladder cancer (GBC) cells, but mechanism is not clear. Neuropilin‐1 ( NRP‐1 ) plays an important role in various malignancies as transmembrane glycoprotein. Our goal was to reveal relationship between CAFs and their potential functions GBC. In this study, we found overexpressed GBC tissue, associated with poor survival up‐regulated by CAFs. The cytokine array cluster analysis...
Abstract Background and Objectives To identify the optimal range minimum number of lymph nodes (LNs) to be examined maximize survival time patients with curatively resected gallbladder adenocarcinoma (GBAC). Methods Data were collected from surveillance, epidemiology, end results database on GBAC who underwent curative resection between 2004 2015. A Bayesian network (BN) model was constructed harvested LNs. Model accuracy evaluated using confusion matrix receiver operating characteristic...
Most patients with gallbladder cancer (GBC) present advanced-stage disease and have a poor prognosis. Radical resection remains the only therapeutic option to improve survival in GBC. This study aimed analyze prognostic factors stage Ⅳ GBC identify subgroup of who might benefit from R0 resection.A total 285 were retrospectively analyzed at our institution January 2008 December 2012. Factors potentially influencing prognosis after surgery by univariate multivariate analyses.The 1-, 3-, 5-year...
Abstract Backgrounds Ampullary adenocarcinoma (AMPAC) is a rare malignancy, treated as pancreatic or intestinal cancer based on its histologic subtype. Little known about the genomic features of Chinese patients with AMPAC. Materials and methods We enrolled 145 AMPAC in our local cohort performed compressive somatic germline genetic testing using 156 gene panel. Expression PD-L1 (clone 28 − 8) was also assessed tumor specimens from 64 patients. Results The frequency alterations (GAs) found...
Abstract Background: The intrahepatic cholangiocarcinoma (iCCA) is highly lethal malignancy of biliary tract cancer. Analysis somatic mutational profiling could help to reveal new prognostic markers and actionable targets for treatment. We aim explore the impact genomic mutation signature tumor burden (TMB) on prognosis iCCA patients. Methods: whole-exome sequencing corresponding clinical data were collected from ICGC portal cBioPortal database detect genes TMB values. To identify hub mutant...
Animal models of intracerebral hemorrhage were established by injection autologous blood into the caudate nucleus in rats. Cell apoptosis was measured flow cytometry and immunohistochemical staining p75 neurotrophin receptor. receptor protein detected immunohistochemistry. mRNA examined quantitative real-time polymerase chain reactions. At 24 hours after modeling, cellular occured around hematoma with upregulation observed, which directly correlated to apoptosis. This observation indicated...
Objective: To examine the value of number metastatic lymph nodes(NMLN), node ratio(LNR) and log odds nodes(LODDS) in assessing prognosis patients with intrahepatic cholangiocarcinoma(ICC). Methods: The clinical pathological data 440 ICC who underwent curative-intent resection 10 Chinese hepatobiliary surgery centers from January 2010 to December 2018 were collected, deadline follow-up was April 30th, 2019. Among them, 205 males 235 females, age (57.0±9.9) years (range:23-83...