A5058672950- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Liver Disease and Transplantation
- Renal and Vascular Pathologies
- Pharmacological Effects and Toxicity Studies
- Healthcare Policy and Management
- Renal Diseases and Glomerulopathies
- Mechanical Circulatory Support Devices
- Liver Disease Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Pregnancy and Medication Impact
- Polyomavirus and related diseases
- Neurological Complications and Syndromes
- HIV/AIDS drug development and treatment
- Clinical Nutrition and Gastroenterology
- Metabolism and Genetic Disorders
- Hepatitis C virus research
- Viral-associated cancers and disorders
- Chronic Kidney Disease and Diabetes
- Organ and Tissue Transplantation Research
- Congenital Anomalies and Fetal Surgery
- Pharmacogenetics and Drug Metabolism
- Geriatric Care and Nursing Homes
Hennepin Healthcare Research Institute
2018-2025
University of Minnesota
2016-2025
The University of Texas Medical Branch at Galveston
2024-2025
Westmead Institute for Medical Research
2024
University of Minnesota Medical Center
2018-2024
Twin Cities Orthopedics
2008-2024
Hennepin County
2024
Sankara Nethralaya
2024
Novem (Netherlands)
2024
Optical Air Data Systems (United States)
2023
Solid organ transplant recipients have elevated cancer risk due to immunosuppression and oncogenic viral infections. Because most prior research has concerned kidney recipients, large studies that include of differing organs can inform etiology.
Data from 2016 show ongoing positive trends in short- and long-term allograft survival, a decrease the number of active listed candi- dates for first time more than decade, with concomitant in- crease deceased donor kidney transplants. Transplant rates that had changed dramatically some groups after implementation new allocation system 2014 are stabilizing, allowing evaluation steady states trends. Many challenges remain adult kid- ney transplantation, including stagnant living transplant,...
The first full year of data after implementation the new kidney allocation system reveals an increase in deceased donor transplants among black candidates and those with calculated panel-reactive antibodies 98%-100%, but a decrease aged 65 years or older. Data from 2015 also demonstrate ongoing positive trends graft patient survival for both living transplants, challenges limited supply kidneys setting increasing demand remain evident. While total number patients on waiting list decreased...
Data on adult liver transplants performed in the US 2016 are no-table for (1) largest total number of (7841); (2) shortest median waiting time recent history (11.3 months); (3) continued reduction waitlist registrations and hepatitis C-related indications; (4) increasing numbers patients whose clinical profiles consistent with non-alcoholic fatty disease; (5) equilibration transplant rates without hepatocellular carcinoma. Despite increase available organs, mortality remained an important...
In 2013, the Organ Procurement and Transplantation Network in United States approved a new national deceased donor kidney allocation policy that introduces profile index (KDPI), which gives scores of 0%-100% based on 10 factors. Kidneys with lower KDPI are associated better post-transplant survival. Important features include first allocating kidneys from donors KDPI≤20% to candidates top 20th percentile estimated survival, adding waiting time dialysis initiation, conferring priority points...
For most end-stage renal disease patients, successful kidney transplant provides substantially longer survival and better quality of life than dialysis, preemptive is associated with outcomes transplants occurring after dialysis initiation. However, numbers in the us have not changed for a decade. Since 2004, total number candidates on waiting list has increased annually. Median time to wait-listed adult patients from 2.7 years 1998 4.2 2008. The discard rate deceased donor kidneys also...
Despite the ongoing severe shortage of available kidney grafts relative to candidates in need, data from 2019 reveal some promising trends. After remaining relatively stagnant for many years, number transplants has increased each year since 2015, reaching highest annual count date 24,273 2019. The patients waiting a transplant United States was stable, despite an increase new added and decrease removed list owing death or deteriorating medical condition. However, these encouraging trends are...
Many positive trends in kidney transplantation were notable 2017. Deceased donor transplant rates and counts continued to rise, the waiting list declined for third year a row after decades of growth, both short- long-term allograft survival improve over year. In total, more than 220,000 patients living United States with functioning allograft. With 3 years data available since implementation new allocation system, better prediction longer-term results policy changes became possible. The also...
A shortage of kidneys for transplant remains a major problem patients with end-stage renal disease. The number candidates on the waiting list continues to increase each year, while organ donation numbers remain flat. Thus, rates adult wait-listed continue decrease. However, pretransplant mortality also show decreasing trend. Many recovered are discarded, and discard increasing. Living have been essentially unchanged past decade, despite introduction desensitization, non-directed donations,...
Data on adult liver transplants performed in the US 2017 are notable for (1) continued growth numbers of new waitlist registrants (11,514) and (8,082); (2) increase transplant rate (51.5 per 100 waitlist-years); (3) a precipitous decrease registrations hepatitis C-related indications; (4) reciprocal increases recipients with alcoholic disease clinical profiles consistent non-alcoholic fatty disease; (5) improvement graft survival despite changing recipient characteristics such as older age...
This year was notable for changes to exception points determined by the geographic median allocation Model End-Stage Liver Disease (MELD) and implementation of National Review Board, which took place on May 14, 2019. The national acuity circle liver distribution policy also implemented but reverted donor service area- region-based boundaries after 1 week. In 2019, growth continued in number new waiting list registrations (12,767) transplants performed (8,896), including living-donor (524)....
Several notable developments in adult liver transplantation the US occurred 2015. The year saw largest number of transplants to date, leading reductions median waiting time, waitlist mortality for all model end-stage disease categories, and candidates on list at end year. Numbers additions performed patients with hepatitis C virus infection decreased first time recent years. However, other diagnoses, such as non-alcoholic fatty alcoholic cirrhosis, became more prevalent. Despite large...
In 2021, liver transplant volume continued to grow, with a record 9,234 transplants performed in the United States, 8,665 (93.8%) from deceased donors and 569 (6.2%) living donors. There were 8,733 (94.6%) adult 501 (5.4%) pediatric recipients. An increase number of donor livers corresponded an overall rate shorter waiting times, although still 10.0% that recovered not transplanted. Alcohol-associated disease was leading indication for both waitlist registration adults, outpacing...