A5020845978- Wildlife Ecology and Conservation
- Renal Transplantation Outcomes and Treatments
- Species Distribution and Climate Change
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Animal Behavior and Welfare Studies
- Rangeland Management and Livestock Ecology
- Ecology and biodiversity studies
- Rangeland and Wildlife Management
- Animal Ecology and Behavior Studies
- Wildlife-Road Interactions and Conservation
- Ecology and Vegetation Dynamics Studies
- Animal Behavior and Reproduction
- Renal and Vascular Pathologies
- Primate Behavior and Ecology
- Transplantation: Methods and Outcomes
- Zoonotic diseases and public health
- Liver Disease and Transplantation
- Renal Diseases and Glomerulopathies
- Animal and Plant Science Education
- Organ and Tissue Transplantation Research
- Human-Animal Interaction Studies
- Blood groups and transfusion
- Environmental Philosophy and Ethics
- Conservation, Biodiversity, and Resource Management
University of Oxford
2016-2025
NYU Langone Health
2024
Sentara Heart Hospital
2024
Cleveland Metroparks
2024
Michigan State University
2012-2021
Michigan Department of Natural Resources
2011-2021
University of Washington
2019
Michigan United
2014-2019
University of Newcastle Australia
2019
Johns Hopkins University
2007-2018
We report a chain of 10 kidney transplantations, initiated in July 2007 by single altruistic donor (i.e., without designated recipient) and coordinated over period 8 months two large paired-donation registries. These transplantations involved six transplantation centers five states. In the case donors their coregistered recipients underwent surgery simultaneously. other cases, "bridge donors" continued as many 5 after own pairs had received transplants. This paired donations, which were not...
Desensitized patients are at high risk of developing acute antibody-mediated rejection (AMR). In most cases, the episodes mild and respond to a short course plasmapheresis (PP) / low-dose IVIg treatment. However, subset experience severe AMR associated with sudden onset oliguria. We previously described utility emergent splenectomy in rescuing allografts this type AMR. not all good candidates for splenectomy. Here we present single case which eculizumab, complement protein C5 antibody that...
The various debates around model selection paradigms are important, but in lieu of a consensus, there is demonstrable need for deeper appreciation existing approaches, at least among the end-users statistics and tools. In ecological literature, Akaike information criterion (AIC) dominates practices, while it relatively straightforward concept, exists what we perceive to be some common misunderstandings its application. Two specific questions arise with surprising regularity colleagues...
Current billing practices and mandates to report surgical outcomes are disincentives treatment of obese patients, who at increased risk for longer hospital stays higher complication rates. The objective this study was quantify the independent association between body mass index (BMI) waiting time kidney transplantation identify potential provider bias against obese. A secondary data analysis performed a prospective cohort 132,353 patients were registered in United States 1995 2006. Among all...
Biopsies of ABO-incompatible and positive crossmatch (HLA-incompatible) renal allografts were retrospectively examined to compare results C4d C3d staining, the correlation between such staining histologic findings suggestive antibody-mediated rejection (AMR). A total 75 biopsies (55 protocol, 17 for graft dysfunction, 3 other indications) 24 grafts 244 (103 129 12 66 HLA-incompatible examined; all stained approximately 40% C3d. In grafts, 80% protocol 59% performed dysfunction showed in...
In kidney paired donation (KPD), incompatible pairs exchange kidneys so that each recipient receives a compatible organ. This modality is underutilized partly because of the difficulty finding suitable match among pairs. Alternatively, recipients with donors might enter KPD arrangements in order to be matched donor predicted give greater allograft durability or for other altruistic reasons. Using simulated and recipients, we investigated impact allowing their participate KPD. For programs...
Despite countless media campaigns, organ donation rates in the United States have remained static while need has risen dramatically. New efforts to increase through public education are necessary address waiting list of over 100,000 patients. On May 1, 2012, online social network, Facebook, altered its platform allow members specify "Organ Donor" as part their profile. Upon such choice, were offered a link state registry complete an official designation, and "friends" network made aware new...
The expression of 12 cytokine and receptor genes during mouse thymic ontogeny has been studied using the polymerase chain reaction. data reveal that IL-2 gene transcription does not begin in thymus until fetal day (Fd) 16. However, IL-2R beta-chain mRNA was detectable throughout period investigation, from Fd 14 to 20. This suggests potential for high or intermediate affinity binding is present before actually expressed. Overall, induction occurred two distinct patterns. In first group,...
When the United Network for Organ Sharing changed its algorithm liver allocation to model end-stage disease (MELD) system in 2002, highest priority shifted patients with renal insufficiency as a major component of their disease. An unintended consequence new was rapid increase number simultaneous liver-kidney transplants (SLK) being performed yearly.Adult recipients deceased donor (LT, n=19,137), kidney (n=33,712), and SLK (n=1,032) between 1987 2006 were evaluated based on data. Recipients...
Frailty increases early hospital readmission and mortality risk among kidney transplantation (KT) recipients. Although frailty represents a high-risk state for this population, the correlates of frailty, patterns 5 components, associated with these are unclear.Six hundred sixty-three KT recipients were enrolled in cohort study (12/2008-8/2015). Frailty, activities daily living (ADL)/instrumental ADL (IADL) disability, Centers Epidemiologic Studies Depression Scale depression, education,...
Abstract Extensive research has demonstrated that urbanization strongly alters ecological processes, often perniciously. However, quantifying the magnitude of urban effects and determining how generalized they can be across systems depends on ways in which is measured modelled. We coupled a formal literature survey with novel conceptual framework to document synthesize myriad metrics used quantify urbanization. The enables clear cataloguing by identifying (a) component measured, (b) method...
Quantifying both the lethal and non-lethal (or “risk”) effects of predation has emerged as a major research focus in carnivore-ungulate systems. While numerous studies have examined risk recent decades, lack standardization approaches impeded progress field. We provide an overview five study design considerations involved assessing responses prey systems, highlighting how different choices can impact strength scope inference. First, we stress importance distinguishing measures (probability...
Liver transplantation from donation after cardiac death (DCD) donors is an increasingly common approach for expansion of the donor organ supply. However, with DCD livers results in inferior graft survival. In this study, we examined and recipient characteristics that are associated poor allograft outcomes present a set criteria permit survival comparable to brain (DBD) grafts both low- high-risk recipients.The United Network Organ Sharing/Organ Procurement Transplantation Registry between...
Single-center studies have reported that liver allograft survival is not affected by preservation in histidine-tryptophan-ketoglutarate (HTK) versus University of Wisconsin (UW) solution. We analyzed the UNOS database transplants performed from July, 2004, through February, 2008, to determine if with HTK (n = 4755) UW 12 673) impacted graft survival. allografts increased 16.8% 2004 26.9% 2008; this was particularly striking among donor after cardiac death (DCD) allografts, rising 20.7% 40.9%...
Documenting the impacts of Pleistocene megafaunal extinctions on predator-prey interactions is a challenge because incomplete fossil record and depauperate extant community structure. We used comparative ecological approach to investigate whether existing prey preference patterns jaguars Panthera onca were potentially affected by in Americas compared with large felids Africa Asia. reviewed literature found 25 studies reporting 3214 jaguar kills recorded throughout species' distribution. that...
Abstract Compassionate conservation focuses on 4 tenets: first, do no harm; individuals matter; inclusivity of individual animals; and peaceful coexistence between humans animals. Recently, compassionate has been promoted as an alternative to conventional philosophy. We believe examples presented by conservationists are deliberately or arbitrarily chosen focus mammals; inherently not compassionate; offer ineffective solutions. charismatic species, notably large predators megaherbivores. The...