A5004399526- Frailty in Older Adults
- Nutrition and Health in Aging
- Health Systems, Economic Evaluations, Quality of Life
- Resilience and Mental Health
- Geriatric Care and Nursing Homes
- Dialysis and Renal Disease Management
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Total Knee Arthroplasty Outcomes
- Hip and Femur Fractures
- Adipose Tissue and Metabolism
- Health disparities and outcomes
- Palliative Care and End-of-Life Issues
- Dementia and Cognitive Impairment Research
- Diabetes Management and Research
- Fault Detection and Control Systems
- Global Health Care Issues
- Balance, Gait, and Falls Prevention
- Community Health and Development
- Occupational Health and Safety Research
- Pharmacology and Obesity Treatment
- Orthopaedic implants and arthroplasty
- Scoliosis diagnosis and treatment
- Food Security and Health in Diverse Populations
- Iron Metabolism and Disorders
Johns Hopkins University
2016-2025
Johns Hopkins Medicine
2016-2025
Johns Hopkins University Applied Physics Laboratory
2020
October 6 University
2016
Background.Frailty assessment provides a means of identifying older adults most vulnerable to adverse outcomes. Attention frailty in clinical practice is more likely with better understanding its prevalence and associations patient characteristics. We sought provide national estimates people.
Frailty has long been an important concept in the practice of geriatric medicine and gerontological research, but integration implementation frailty concepts into clinical United States slow. The National Institute on Aging (NIA) Intramural Research Program Johns Hopkins Older Americans Independence Center sponsored a symposium to identify potential barriers that impede movement highlight opportunities facilitate further practice. Primary subspecialty care providers, investigators working...
Frailty increases early hospital readmission and mortality risk among kidney transplantation (KT) recipients. Although frailty represents a high-risk state for this population, the correlates of frailty, patterns 5 components, associated with these are unclear.Six hundred sixty-three KT recipients were enrolled in cohort study (12/2008-8/2015). Frailty, activities daily living (ADL)/instrumental ADL (IADL) disability, Centers Epidemiologic Studies Depression Scale depression, education,...
Although the field of frailty research has expanded rapidly, it is still a nascent concept within clinical specialties. Frailty, conceptualized as greater vulnerability to stressors because significant depletion physiological reserves, predicts poorer outcomes in several medical specialties, including cardiology, human immunodeficiency virus care, and nephrology, behavioral social sciences. Lack consensus definition, proliferation measurement tools, inadequate understanding biology frailty,...
Abstract Background Racial/ethnic frailty prevalence disparities have been documented. Better elucidating how these operate may inform interventions to eliminate them. We aimed determine whether physical phenotype (PFP) (i) are explained by health aspects, (ii) vary income, or (iii) differ in degree across individual PFP criteria. Methods Data came from the 2011 National Health and Aging Trends Study baseline evaluation. The study sample (n = 7,439) included persons all residential settings...
Abstract Resilience to stressors has emerged as a major gerontological concept aiming promote more positive outcomes for older adults. Achieving this aim relies on determining mechanisms underlying capacity respond resiliently. This paper seeks proof of principle the hypothesis that physical aspects said are rooted in fitness one’s physiology governing stress response, conceptualized dynamical system. The Study Physical Aging (“SPRING”) leveraged stimulus-response experiments characterize...
Objectives Evidence suggests vitamin D deficiency is associated with developing frailty. However, cardiometabolic factors are related to both conditions and may confound and/or mediate the D–frailty association. We aimed determine association of concentration incidence frailty, role diseases (cardiovascular disease, diabetes, hyperlipidemia, hypertension) in this relationship. Design Prospective longitudinal cohort study (7 visits from 1994–2008). Setting Baltimore, Maryland. Participants...
The Fried frailty phenotype, a measure of physiologic reserve defined by 5 components (exhaustion, unintentional weight loss, low physical activity, slow walking speed, and poor grip strength), is associated with outcomes among ESRD patients. However, these may not fully capture in this population. We aimed to ascertain opinions clinicians patients about the usefulness phenotype interventions improve patients, identify novel further characterize ESRD. Clinicians who treat adults completed...
Abstract Introduction “Frailty” has attracted attention for its promise of identifying vulnerable older adults, hence potential use to better tailor geriatric health care. There remains substantial controversy, however, regarding nature and ascertainment. Recent years have seen a proliferation frailty assessment methods. We argue that the development assessments should be grounded in “validation”—the process substantiating measurement accurately precisely measures what it intends, identify...
Abstract Purpose of Review The purpose this review is to summarize the current data for comparative effectiveness glycemic control in older adults. Recent Findings In last several years, professional societies have released guidelines adults, generally recommending individualized HbA1c goals. However, recent observational studies demonstrate that many adults remain aggressively managed and are at increased risk hypoglycemia. Large randomized trials with diabetes failed show convincing...
Although life-saving, the physiologic stress of hemodialysis initiation contributes to physical impairment in some patients. Mortality risk assessment following is underdeveloped and does not account for change over time. Measures resilience, ability a state overcome stressors, may help identify patients at higher mortality inform clinical management.We created 3 resilience categories (improving, stable, declining) trajectories 4 phenotypes (physical function [PF], mental health [MH],...
Abstract Understanding the physiological basis of physical resilience to clinical stressors is crucial for well‐being older adults. This article presents a novel framework discover biological underpinnings in adults as part “Characterizing Resiliencies Physical Stressors Older Adults: A Dynamical Physiological Systems Approach” study, also known The Study Resilience and Aging (SPRING). resilience, defined capacity person withstand quickly recover or improve upon baseline functional level,...
The Fostering African American Improvement in Total Health! (FAITH!) Nutrition Education Program is a theory-based, multicomponent health intervention developed and operated partnership with an East Baltimore church. program aims to improve eating habits, as well knowledge beliefs about healthy eating, among adults order prevent diseases related dietary choices. This article addresses the development, design, formative research that informed FAITH! program. main components are also...
Abstract Losartan is an oral antihypertensive agent that rapidly metabolized to EXP3174 (angiotensin-subtype-1-receptor blocker) and EXP3179 (peroxisome proliferator-activated receptor gamma [PPARγ] agonist), which was shown in animal studies reduce inflammation, enhance mitochondrial energetics, improve muscle repair physical performance. We conducted exploratory pilot study evaluating losartan treatment prefrail older adults (age 70–90 years, N = 25). Participants were randomized control...
Abstract Background Frailty syndrome disproportionately affects older people, including 15% of non-nursing home population, and is known to be a strong predictor poor health outcomes. There growing interest in incorporating frailty assessment into research clinical practice, which may provide an opportunity improve doctor patient communication. Methods We conducted focus groups discussions solicit input from adult care recipients (non-frail, pre-frail, frail), their informal caregivers,...
Physical frailty is defined as a syndrome of decreased physiologic reserve conferring vulnerability to functional decline, mortality, and other adverse outcomes upon experiencing stressors. Self-efficacy, which confidence in one's ability perform well domain life, modifiable. Self-efficacy associated with improved health behavior chronic disease burden. Its relationship unknown. The purpose this study was evaluate whether general self-efficacy proxy predicts incident frailty.A nationally...
The ability to identify frail older adults using a self-reported version of the physical frailty phenotype (PFP) that has been validated with standard PFP could facilitate detection in clinical settings.We collected data from volunteers (N = 182), ages 65 years and older, an aging research registry Baltimore, Maryland. Measurements included: (walking speed, grip strength, weight loss, activity, exhaustion); questions about walking handgrip strength. We compared objectively-measured gait...
Abstract We aimed to study the cross-sectional association between self-perception of aging (SPA) and frailty paradox, defined as self-reporting excellent/very good health despite being frail or fair/poor robust. The sample included 2,950 participants from Health Retirement Study (2008 wave) who were 65 years older, completed Psychosocial Lifestyle Questionnaire, had no missing data on variables in models. Frailty was measured by physical phenotype. Self-reported (SRH) rated either...
Abstract Objectives Our primary objective was to examine the distribution of 3-m usual walk, five repeated chair stands, and three static balance stance performances among age gender subgroups adults at least 65 years in two national data sets. We secondarily determined whether demographic–function associations varied across sets, birth cohorts, or models incorporating from those “unable do” tasks. Methods Two nationally representative sets were used generate survey weight-adjusted...