This study investigates the expression of cyclooxgenase (COX)-2 and matrix metalloproteinase (MMP)-2 in patients with adenomyosis or endometrial polyps their possible relation to microvascular density these lesions. The subjects were 25 adenomyosis, 30 polyps, 20 female controls. COX-2, MMP-2, CD34 was studied immunohistochemically. Microvesseldensity (MVD) calculated by counting CD34-positive vascular endothelial cells. quantity intensity COX-2 endometrium did not vary during menstrual...

Multiple protective effects of erythropoietin (EPO), such as antiapoptotic, antioxidant, angiogenic and neuroprotective effects, against ischemia have been demonstrated in cell culture animal models. Genistein is also a potent tyrosine kinase inhibitor. The aims the present study were to evaluate EPO on renal ischemia/reperfusion injury determine role pathway this process.Sprague-Dawley rats assigned five groups: (i) sham (Group I); (ii) control with (right nephrectomy clamping left pedicle...

Background: This study was designed to examine the effects of desferrioxamine and quercetin on hepatic ischaemia-reperfusion injury in rat.Methodology: Thirty Wistar albino rats were randomized into five groups. Group I control group. II received no treatment. III group IV intramuscular injections (100 mg/kg per day) (50 respectively. V administered combination. After treatment for 3 days, groups II, III, IV, exposed total ischaemia 45 minutes. Plasma alanine aminotransferase levels,...

The aim of this study is to investigate the putative neuroprotective effect alpha-lipoic acid (LA) on spinal ischemia/reperfusion (I/R) injury in rabbits.Thirty-five adult female New Zeland rabbits, weighing 2,000-3,500 g (mean: 2,800), were divided randomly into five groups seven rabbits each (n: 7) as Group 1: sham, only laparotomy; 2 (İ/R): I/R; 3 (LA): I/R and 100 mg/kg LA; 4 (MP): 30 methylprednisolone (MP); 5 (LA + MP): LA plus MP.A statically significant LA, MP, MP lowering...

The aim of the study is to assess expression levels CPEB4, APC, TRIP13, EIF2S3, EIF4A1, IFNg, PIK3CA and CTNNB1 genes in tumors peripheral bloods colorectal cancer patients stages I–IV.The mRNA were determined tumor tissues blood samples 45 colon 5 healthy individuals. Real-time polymerase chain reaction method was used for analysis.The level CPEB4 gene significantly downregulated upregulated relative controls (P < 0.05). APC TRIP13 also EIF2S3 blood. EIF4A1 IFNg both blood.TRIP13 up...

Background: PTEN seems to play an important role in cell cycle, growth, migration, and death. Integrins are surface receptors that a the regulation of proliferation, differentiation, implantation, embryogenesis. inhibits β1 integrin signaling. The objective this study is investigate expression placental tissues early spontaneous abortion first third trimesters normal pregnancy. Method: A total 43 tissue samples were evaluated using immunohistochemistry for integrin. Group 1 included...

Osteochondroma rarely affects talus although it is the most common primary bone tumor. We report a case of talar osteochondroma in 6 year-old boy. There was no recurrence two years after local resection lesion.

Malignant schwannoma is a rare sarcoma that located mostly on trunk and extremities; the head neck are unusual sites for its development. Almost half of these tumors arise from neurofibromas with or without von Recklinghousen's disease, most remainder develop de novo peripheral nerve trunks. Development in superficial soft tissues extremely rare.To present case malignant scalp, which an uncommon presentation.An 80-year-old male patient presented painless ulceration his scalp. The clinical...

Gangliogliomas of the spinal cord are very unusual and anaplastic variant these tumors is extremely rare. In gangliogliomas, malignant changes (hypercellularity, vascular proliferation, necrosis, high numbers mitotic figures) typically evident in glial element tumor. can arise any part central nervous system features adult pediatric cases differ significantly. We describe case a patient who had ganglioglioma extending from T&lt;sub&gt;9&lt;/sub&gt; to L&lt;sub&gt;3&lt;/sub&gt; level. The...

β-Catenin is a critical component of the Wnt signaling pathway that regulates cell proliferation and differentiation. leads to stabilization cytosolic β-catenin translocation nucleus, where it binds with T-cell factor promotes transcription changes in target gene expression, including vascular endothelial growth cyclin D1. The aim this study was assess expression D1 correlate them some clinicopathologic parameters.In study, we analyzed paraffin-embedded specimens from 42 patients pT3...

Erythroderma is generalized exfoliative dermatitis, which involves more than 90% of the patient's skin. The most common cause erythroderma exacerbation an underlying skin disease, malignancies or drug reaction. There a long list drugs responsible for such as antiepileptics, sulfonamides, antibiotics, and angiotensin converting enzyme (ACE) inhibitors. We herein report case due to gliclazide usage also proved by histopathologic examination patch test. could not find any gliclazide, oral...

Objective: Superficial tumors including Ta, Tis, and T1 make up 75% of urothelial carcinomas the bladder.While behavior these superficial cancers is relatively benign, invasive have a significant mortality rate.However, Ta might display different biological behavior.There therefore great need for biomarkers that can accurately distinguish in addition to tumor grade stage.our aim was determine immunohistochemical expression profile insulin like growth factor ii mrna binding Protein 3 (iMP3)...

Seven cases of an unusual low-grade vascular tumor were reported in a recent study. Despite its similarity to epithelioid sarcoma, this was termed sarcoma-like hemangioendothelioma because the subtle histopathological and immunohistochemical differences. Another case rare entity 70-year-old woman who suffered from painful mass on anterior aspect right cubital fossa is presented here, together with review relevant literature.