A5022988793- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Obstructive Sleep Apnea Research
- Electrochemical Analysis and Applications
- Electrochemical sensors and biosensors
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Sarcoidosis and Beryllium Toxicity Research
- Cardiovascular Disease and Adiposity
- Molecular Junctions and Nanostructures
- Cardiac Structural Anomalies and Repair
- Spectroscopy and Quantum Chemical Studies
- Cerebrovascular and Carotid Artery Diseases
- Pleural and Pulmonary Diseases
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Cardiac, Anesthesia and Surgical Outcomes
- Mesenchymal stem cell research
- Vasculitis and related conditions
- Gold and Silver Nanoparticles Synthesis and Applications
- Air Quality and Health Impacts
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inhalation and Respiratory Drug Delivery
- Advanced biosensing and bioanalysis techniques
Acıbadem University
2022-2025
Istanbul University
2015-2024
Kafkas University
2023-2024
Seoul Medical Center
2019
Technische Universität Berlin
2008-2017
National University Heart Centre Singapore
2017
National University of Singapore
2017
University College London
2017
National Heart Centre Singapore
2017
Bezmiâlem Vakıf Üniversitesi
2011-2016
Coronary revascularization guided by fractional flow reserve (FFR) is associated with better patient outcomes after the procedure than angiography alone. It unknown whether instantaneous wave-free ratio (iFR), an alternative measure that does not require administration of adenosine, will offer benefits similar to those FFR.
Microvascular perfusion is often impaired after primary percutaneous coronary intervention (PCI). We proposed that in situ thrombosis might contribute to poor myocardial this setting. To test hypothesis, we evaluated the effect of low-dose intracoronary streptokinase administered immediately PCI.Forty-one patients undergoing PCI were randomly assigned receive (250 kU) or no additional therapy. Two days later, cardiac catheterization was repeated, and hemodynamic end points measured with use...
The aim of this study was to investigate the clinical outcomes patients deferred from coronary revascularization on basis instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) measurements in stable angina pectoris (SAP) and acute syndromes (ACS). Assessment stenosis severity with pressure guidewires is recommended determine need for myocardial revascularization. safety deferral pooled per-protocol population (n = 4,486) DEFINE-FLAIR (Functional Lesion Intermediate Stenosis...
Background and objective: The aim of this study was to investigate oxidative stress status in different stages histological types lung cancer. Methods: Forty‐nine cancer patients, who had not received any therapy, 20 healthy subjects were chosen for the study. Lung patients divided into those with early stage or advanced disease. tumour type adenocarcinoma 24 squamous cell carcinoma 21 large four. We measured serum nitrite, nitrate, ascorbic acid, retinol, β‐carotene ceruloplasmin levels,...
Background: Recent epidemiological data suggested that there is a relationship between periodontal health and atherosclerotic coronary heart disease. Although hypothetical models were proposed, the exact mechanism of this association has not been clarified. The aim study to investigate whether an endothelial dysfunction in patients with chronic periodontitis and, if present, recovery possible therapy. Methods: groups consisted 28 (mean age: 45.5 ± 8.6 years) without any vascular disease, 26...
IMPORTANCEThe optimal anticoagulant for patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) managed an invasive strategy remains controversial.OBJECTIVE To compare the clinical efficacy and safety of otamixaban, a novel intravenous direct factor Xa inhibitor, that unfractionated heparin plus downstream eptifibatide in NSTE-ACS undergoing planned early strategy.DESIGN, SETTING, AND PARTICIPANTS Randomized, double-blind, active-controlled superiority trial enrolled 13...
Background The contribution of functionally disturbed coronary autoregulation and structurally impaired microvascular vasodilatory function to reduced flow velocity reserve, reflecting microcirculation in diabetes mellitus ( DM ), has not been clearly elucidated. objective this study was identify the mechanism impairment relation duration disease. Methods Results Coronary velocities anterior descending artery were assessed by transthoracic echocardiography following angiography revealing...
Importance The differences between the use of fractional flow reserve (FFR) or instantaneous wave-free ratio (iFR) in long term are unknown. Objective To compare long-term outcomes iFR- and FFR-based strategies to guide revascularization. Design, Setting, Participants DEFINE-FLAIR multicenter study randomized patients with coronary artery disease either iFR FFR as a pressure index Patients from 5 continents angiographically intermediate severity stenoses who underwent hemodynamic...
A nanostructured gold−silver-hybrid electrode for SER spectroelectrochemistry was developed which advantageously combines the electrochemical properties and chemical stability of Au strong surface enhancement (resonance) Raman scattering by Ag. The layered device consists a massive nanoscopically rough Ag electrode, thin (2 nm) organic layer, ca. 20 nm thick film that may be coated self-assembled monolayers protein adsorption. SERR-spectroscopic performance this is demonstrated using heme...
Human sulfite oxidase (hSO) was immobilised on SAM-coated silver electrodes under preservation of the native heme pocket structure cytochrome b5 (Cyt b5) domain and functionality enzyme. The redox properties catalytic activity entire enzyme were studied by surface enhanced resonance Raman (SERR) spectroscopy cyclic voltammetry (CV) compared to isolated when possible. It is shown that heterogeneous electron transfer hSO sensitively depend local environment Increasing ionic strength buffer...
We present a preparation procedure for small sized biocompatibly coated Ag nanoparticles with tunable surface plasmon resonances. The conditions were optimised respect to the resonance Raman signal enhancement of heme proteins and preservation native protein structure.
Objectives Early detection of microvascular dysfunction after acute myocardial infarction (AMI) could identify patients at high risk adverse clinical outcome, who may benefit from adjunctive treatment. Our objective was to compare invasively measured coronary flow reserve (CFR) and hyperaemic resistance (HMR) for their predictive power long-term outcome cardiac magnetic resonance (CMR)-defined injury (MVI). Methods Simultaneous intracoronary Doppler velocity pressure measurements acquired...
Physicians are not always comfortable deferring treatment of a stenosis in the left anterior descending (LAD) artery because perception that there is high risk major adverse cardiac events (MACE). The authors describe, using DEFINE-FLAIR (Functional Lesion Assessment Intermediate Stenosis to Guide Revascularisation) trial, MACE rates when LAD lesions deferred, guided by physiological assessment fractional flow reserve (FFR) or instantaneous wave-free ratio (iFR).
In acute myocardial infarction (AMI), increased neutrophil count has been associated with more severe coronary artery disease and larger infarct size. Increased mean platelet volume (MPV) is also poor clinical outcome impaired angiographic reperfusion in patients AMI. However, the associations of MPV indices tissue level were not fully elucidated.To elucidate relationship between baseline on presentation microvascular injury anterior AMI treated primary percutaneous intervention (pPCI).41...
Spectroscopic data of dye decolorizing peroxidases (DyPs) from Bacillus subtilis (BsDyP), an A subfamily member, and Pseudomonas putida (PpDyP), a B enzyme, reveal distinct heme coordination patterns the respective active sites. In solution, both enzymes show heterogeneous spin population, with six-coordinated low-spin state being most populated in former five-coordinated quantum mechanically mixed-spin latter. We ascribe poor catalytic activity BsDyP to presence catalytically incompetent...
Cellobiose dehydrogenase catalyzes the oxidation of various carbohydrates and is considered as a possible anode catalyst in biofuel cells. It has been shown that catalytic performance this enzyme immobilized on electrodes can be increased by presence calcium ions. To get insight into Ca(2+) -induced changes we employ surface-enhanced vibrational (SERR SEIRA) spectroscopy together with electrochemistry. Upon addition ions electrochemical measurements show shift turnover signal to more...
<h3>Importance</h3> Invasive physiologic indices such as fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are used in clinical practice. Nevertheless, comparative prognostic outcomes of iFR-guided FFR-guided treatment patients with type 2 diabetes have not yet been fully investigated. <h3>Objective</h3> To compare 1-year or without the Functional Lesion Assessment Intermediate Stenosis to Guide Revascularization (DEFINE-FLAIR) trial. <h3>Design, Setting,...