A5000225140- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Mechanical Circulatory Support Devices
- Long-Term Effects of COVID-19
- Cardiac Ischemia and Reperfusion
- Mesenchymal stem cell research
- Cardiac tumors and thrombi
- Venous Thromboembolism Diagnosis and Management
- Coronary Artery Anomalies
- Aortic aneurysm repair treatments
- Renal and Vascular Pathologies
- Cardiac electrophysiology and arrhythmias
- Cultural and Sociopolitical Studies
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Linguistics and Cultural Studies
- Inflammatory mediators and NSAID effects
Istanbul University
2011-2023
Fundación Juan March
2007
Turkish Society of Cardiology
2006
In-Q-Tel
2002
Microvascular perfusion is often impaired after primary percutaneous coronary intervention (PCI). We proposed that in situ thrombosis might contribute to poor myocardial this setting. To test hypothesis, we evaluated the effect of low-dose intracoronary streptokinase administered immediately PCI.Forty-one patients undergoing PCI were randomly assigned receive (250 kU) or no additional therapy. Two days later, cardiac catheterization was repeated, and hemodynamic end points measured with use...
Background The contribution of functionally disturbed coronary autoregulation and structurally impaired microvascular vasodilatory function to reduced flow velocity reserve, reflecting microcirculation in diabetes mellitus ( DM ), has not been clearly elucidated. objective this study was identify the mechanism impairment relation duration disease. Methods Results Coronary velocities anterior descending artery were assessed by transthoracic echocardiography following angiography revealing...
In acute myocardial infarction (AMI), increased neutrophil count has been associated with more severe coronary artery disease and larger infarct size. Increased mean platelet volume (MPV) is also poor clinical outcome impaired angiographic reperfusion in patients AMI. However, the associations of MPV indices tissue level were not fully elucidated.To elucidate relationship between baseline on presentation microvascular injury anterior AMI treated primary percutaneous intervention (pPCI).41...
Background: Accumulating evidence suggests that inflammatory mechanisms play a central role in the development, progression and outcome of atherosclerosis. Recent statins improve anti-inflammatory, anti-thrombotic endothelial functions, along with their lipid-decreasing effects. We examined effect on function using biochemical markers dysfunction brachial artery flow-mediated dilatation (FMD). Methods: Thirty male patients presenting acute coronary syndrome (ACS) 26 age-matched healthy...
AimThe aim of the study was to determine if tissue Doppler imaging (TDI)-derived myocardial acceleration during isovolumic contraction (IVA) tricuspid lateral annulus could be used in early detection RV systolic dysfunction patients with mitral stenosis (MS), before clinical signs systemic venous congestion occur.
Aspirin resistance may increase the risk of major adverse cardiac events (MACE) more than threefold in patients with stable coronary artery disease (CAD). This study aimed to determine prevalence aspirin CAD, role on outcome follow-up, and effect clopidogrel therapy MACE prevention aspirin-resistant individuals. We detected 234 CAD. Platelet function was determined by PFA-100 collagen and/or epinephrine ADP cartridges. The mean follow-up time 20.6 +/- 6.9 months. primary endpoints were...
Myocardial injury caused by COVID-19 was reported in hospitalized patients previously. But the information about cardiac consequences of after recovery is limited. The aim study comprehensive echocardiography assessment right ventricular (RV) recovered from COVID-19. This a prospective, single-center study. After COVID-19, performed consecutive 79 that attended follow-up visits July 15 to November 30, 2020. According at home vs hospital, were divided into two groups: (n = 43) and hospital...
Connection between the course of microvascular and infarct remodeling processes over time after reperfused ST-elevation acute myocardial infarction has not been fully elucidated. The aim this study is to investigate association temporal changes in hemodynamics microcirculation infarcted territory size (IS) primary percutaneous coronary intervention patients with infarction.Thirty-five admitted undergoing were enrolled study. Coronary flow reserve (CFR), index resistance (IMR), IS assessed 2...
Background Intramyocardial edema and hemorrhage are key pathological mechanisms in the development of reperfusion-related microvascular damage ST-segment-elevation myocardial infarction. These processes may be facilitated by abrupt restoration intracoronary pressure flow triggered primary percutaneous coronary intervention. We investigated whether pressure-controlled reperfusion via gradual reopening infarct-related artery limit injury patients undergoing Methods Results A total 83 with...
Polymorphisms in DNA repair genes may be associated with differences the efficiency of damage and influence an individual's risk atherosclerosis. Genetic research on coronary artery disease (CAD) has traditionally focused investigation aimed at identifying disease-susceptibility genes. The aim this study was to investigate relationship between AP-endonuclease-1 (Asp148Glu), XRCC1 (Arg399Gln), XRCC3 (Thr241Met), XPD (Lys751Gln), XPG (Asp1104His), hOGG1 (Ser326Cys), gene polymorphisms...
In diabetes mellitus (DM) patients, left ventricular dysfunction is widely evaluated and established by conventional diagnostic methods, whereas right (RV) function not as sufficiently evaluated. The aim of this study to assess the preclinical effects DM on RV using novel Tissue Doppler Imaging (TDI)-derived indices.The included 96 patients with type II [60 only 36 coexisting hypertension (DMHT)] 40 healthy controls. Conventional parameters TDI-derived systolic velocities tricuspid annulus...
Aspirin resistance could be defined as thrombotic and embolic cardiovascular events despite regular aspirin therapy. The study aimed to determine the profile prevalence of in coronary artery disease patients. We evaluated a cohort 505 patients with diagnosis taking 80–300 mg daily. Platelet functions were analyzed by Function Analyzer (PFA)-100 collagen epinephrine cartridges ADP cartridges. A closure time 186 s or less cartridge was resistance. Of patients, 118 (23.4%) resistant PFA-100....